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EXOSC8

  • Official Full Name

    exosome component 8

  • Overview

    This gene encodes a 3-5 exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6.
  • Synonyms

    EXOSC8; exosome component 8; exosome complex component RRP43; bA421P11.3; CBP interacting protein 3; CIP3; EAP2; OIP2; Opa interacting protein 2; p9; RRP43; Rrp43p; OIP-2; CBP-interacting protein 3; opa-interacting protein 2; exosome complex exonuclease R;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EXOSC8-3580H Recombinant Human EXOSC8 Protein, GST-tagged Wheat Germ GST
Human EXOSC8-12600H Recombinant Human EXOSC8, His-tagged E.coli His 1-276a.a.
Human EXOSC8-136H Recombinant Human EXOSC8, His-tagged E.coli His 1-276aa
Human EXOSC8-6498HCL Recombinant Human EXOSC8 293 Cell Lysate HEK293 N/A
Human EXOSC8-5452H Recombinant Human EXOSC8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EXOSC8-301487H Recombinant Human EXOSC8 protein, GST-tagged E.coli GST Met1-Lys276
Human EXOSC8-0729H Recombinant Human EXOSC8 Protein (M1-K276), Tag Free E.coli No tag M1-K276
Human EXOSC8-4433HF Recombinant Full Length Human EXOSC8 Protein, GST-tagged In Vitro Cell Free System GST 276 amino acids
Human EXOSC8-0730H Recombinant Human EXOSC8 Protein (M1-K276), His/Strep tagged E.coli His/Strep M1-K276
Mouse Exosc8-2894M Recombinant Mouse Exosc8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque EXOSC8-1523R Recombinant Rhesus monkey EXOSC8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EXOSC8-1348R Recombinant Rhesus Macaque EXOSC8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EXOSC8-1348R-B Recombinant Rhesus Macaque EXOSC8 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish EXOSC8-853Z Recombinant Zebrafish EXOSC8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EXOSC8 Related Articles

EXOSC8 involved in several pathways and played different roles in them. We selected most pathways EXOSC8 participated on our site, such as ATF4 activates genes, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOSC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ATF4 activates genesDCP2;KCNA3;DDIT3;EXOSC8
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNAZFP36L1B;MAPKAPK2B;ZFP36L1A;EXOSC8;DCP2;ZFP36L1
Deadenylation-dependent mRNA decayDCP1B;TNKS1BP1;EIF4EB;EIF4B;LSM6;DCP2;EIF4E;EXOSC8;DDX6
Gene ExpressionZNF225;ZNF287;PEAK1;ZNF443;COX4I1;TACO1;ARHGEF38;ZNF691;TRMT1
KSRP (KHSRP) binds and destabilizes mRNAEXOSC8;DCP2;KHSRP
Metabolism of proteinsEXOSC8;PAM16;MTX2;RNF2;APCS;MAN1A2;FKBP14;SFTPBB;UBA2
PERK regulates gene expressionDCP2;EXOSC8
RNA degradationPABPC1L;CNOT1;CNOT4;PABPC4;EXOSC8;PABPC1;EDC3;HSPD1;TOB1

EXOSC8 has several biochemical functions, for example, AU-rich element binding, NOT exoribonuclease activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOSC8 itself. We selected most functions EXOSC8 had, and list some proteins which have the same functions with EXOSC8. You can find most of the proteins on our site.

Function Related Protein
AU-rich element bindingZFP36L3;NUDT21;EXOSC4;EXOSC9;ZFP36L1;ELAVL1;EXOSC8;CPSF5;DND1
NOT exoribonuclease activityEXOSC8;EXOSC4;EXOSC2;EXOSC5;EXOSC3;EXOSC1;EXOSC7
poly(A) RNA bindingMRPL40;GANAB;RPS19BP1;DHX29;DHX9;RBM12B;CHTOP;ZFP579;SART1
protein bindingNKAP;CLEC16A;PSEN2;REV1;C10orf33;HSP90B1;PRPS1;ERCC3;TMA16

EXOSC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOSC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOSC8.

EXOSC5; EXOSC3; EXOSC2; DIS3L; 9098

Eggens, VRC; Barth, PG; et al. EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations. ORPHANET JOURNAL OF RARE DISEASES 9:-(2014).
Lim, SJ; Boyle, PJ; et al. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. NUCLEIC ACIDS RESEARCH 41:2963-2980(2013).
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