Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

EXT2

Official Full Name

exostosin 2
Overview

EXT2 is one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses.
Synonyms

EXT2; exostosin 2; exostoses (multiple) 2; exostosin-2; Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase; N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase; SOTV; multiple exostoses protein 2; putative tumor suppressor protein EXT2; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Bos taurus (Bovine)
Chicken
Human
Mouse
Mus musculus (Mouse)
Zebrafish

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EXT2-12604H	Recombinant Human EXT2, GST-tagged	E.coli	GST	C-term-350a.a.	$319 / 25ug
Human	EXT2-3585H	Recombinant Human EXT2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EXT2-6496HCL	Recombinant Human EXT2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	EXT2-1446H	Recombinant Human EXT2 Protein, His-tagged	E.coli	N-His	Pro47-Phe253	Inquiry
Human	EXT2-4447HF	Recombinant Full Length Human EXT2 Protein, GST-tagged	In Vitro Cell Free System	GST	718 amino acids	Inquiry
Mouse	EXT2-5392M	Recombinant Mouse EXT2 Protein	Mammalian Cell	His		Inquiry
Mouse	EXT2-2909M	Recombinant Mouse EXT2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	EXT2-2909M-B	Recombinant Mouse EXT2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Bos taurus (Bovine)	RFL3632BF	Recombinant Full Length Bovine Exostosin-2(Ext2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-718)	Inquiry
Mus musculus (Mouse)	RFL14814MF	Recombinant Full Length Mouse Exostosin-2(Ext2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-718)	Inquiry
Zebrafish	EXT2-1866Z	Recombinant Zebrafish EXT2	Mammalian Cell	His		Inquiry
Chicken	EXT2-3003C	Recombinant Chicken EXT2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EXT2 Related Articles
EXT2 Related Research Area

EXT2 involved in several pathways and played different roles in them. We selected most pathways EXT2 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycosaminoglycan biosynthesis - heparan sulfate / heparin	HS3ST1L1;EXTL2;HS6ST3B;XYLT1;GLCE;HS3ST1;EXT1A;EXT2;HS2ST1
Metabolic pathways	OGDHL;CERS1;NDUFS8B;PNLIPRP2;CDS2;ALDOCB;ATP6V0D1;GRHPR;BDH2

EXT2 has several biochemical functions, for example, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity, contributes_to acetylglucosaminyltransferase activity, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EXT2 itself. We selected most functions EXT2 had, and list some proteins which have the same functions with EXT2. You can find most of the proteins on our site.

Function	Related Protein
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	EXT1A;EXT1;EXT1B;EXT2;EXT1C
contributes_to acetylglucosaminyltransferase activity
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	EXT1C;EXT2;EXT1;EXT1A;EXTL1;EXT1B
glucuronosyltransferase activity	UGT2B15;UGT3A1;UGT5G1;UGT1A9;B3GNT1;UGT5G2;UGT1B5;UGT1A7;UGT8A
heparan sulfate N-acetylglucosaminyltransferase activity	EXT1;EXT2
metal ion binding	SDHD;SORBS2;RCV1;MT1;CFI;PVALB5;ZFP507;ZFP579;ITGB2
protein heterodimerization activity	H2AFB2;BNIP3;TAL1;KCNN1;ATF3;MEIS1;H2AFZ;GUCY1A3;DDX1
NOT protein homodimerization activity	EXT2;MECOM;KCNA3;MSH3;DDIT3;MLXIPL;MSH6;NUDT16L1;MYO9B
transferase activity, transferring glycosyl groups	UGT8A;FUT9A;GYG1A;UGT2A5;ST3GAL5L;UGT1B2;MGAT4C;PNP4B;ALG6

EXT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXT2.

STK16; SNCG; FABP4; CNTF; HNF4A; RPS29; CRB1; TCEB1; HYOU1; SLC22A2; PFDN1; TK1; ANXA7; CDKN1A; SMN1; yapA; GSKIP

Nadanaka, S; Kagiyama, S; et al. Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes. BIOCHEMICAL JOURNAL 454:133-145(2013).

Multhaupt, HAB; Couchman, JR; et al. Heparan Sulfate Biosynthesis: Methods for Investigation of the Heparanosome. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:908-915(2012).

Tumor Suppressors