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EYA1

Official Full Name

eyes absent homolog 1 (Drosophila)
Overview

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.
Synonyms

EYA1; eyes absent homolog 1 (Drosophila); BOR, eyes absent (Drosophila) homolog 1; eyes absent homolog 1; BOP; BOR; EYA1_HUMAN; eyes absent 1; eyes absent 1 homolog; eyes absent homolog1; MGC141875;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EYA1-26641TH	Recombinant Human EYA1	Wheat Germ	N/A	71 amino acids	Inquiry
Human	EYA1-48H	Recombinant Human EYA1 protein	E.coli	N/A	592aa	Inquiry
Human	EYA1-3590H	Recombinant Human EYA1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EYA1-6492HCL	Recombinant Human EYA1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	EYA1-4456HF	Recombinant Full Length Human EYA1 Protein, GST-tagged	In Vitro Cell Free System	GST	470 amino acids	Inquiry
Zebrafish	EYA1-8797Z	Recombinant Zebrafish EYA1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

EYA1 involved in several pathways and played different roles in them. We selected most pathways EYA1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EYA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	GOLPH3L;ERG;MMP3;REL;H3F3B;HIST1H3D;RXRG;HIST2H3A;FCGR1

EYA1 has several biochemical functions, for example, RNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EYA1 itself. We selected most functions EYA1 had, and list some proteins which have the same functions with EYA1. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	SFPI1;ELAVL1;ZNF385C;THOC7;KHDC3L;FARSB;EIF4EA;DDX25;RBBP7
metal ion binding	ERCC5;ZUFSP;ZKSCAN3;TKT;KLF10;TEC;ZFP36L2;ATP2B2;ZNF329
protein binding	PHYHD1;SPRED1;TNS3;BAG6;ATP1A1;MYL12B;SMAD7;AIRE;KBTBD7
protein tyrosine phosphatase activity	DUSP2;CDC14AB;PTPN9;PTPRG;CDC14C;EYA4;PTPN13;DUSP8A;PTPRM

EYA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EYA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EYA1.