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EYA3

Official Full Name

eyes absent homolog 3
Overview

EYA3 (eyes absent homolog 3) functions as a tyrosine phosphatase that specifically dephosphorylates Tyr-142 of histone H2AX (H2AXY142ph). EYA3 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes co
Synonyms

EYA3; eyes absent homolog 3 (Drosophila); eyes absent (Drosophila) homolog 3; eyes absent homolog 3; DKFZp686C132; eyes absent 3;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EYA3-26817TH	Recombinant Human EYA3	Wheat Germ	N/A	103 amino acids	Inquiry
Human	EYA3-3593H	Recombinant Human EYA3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EYA3-4458HF	Recombinant Full Length Human EYA3 Protein, GST-tagged	In Vitro Cell Free System	GST	536 amino acids	Inquiry
Mouse	EYA3-5398M	Recombinant Mouse EYA3 Protein	Mammalian Cell	His		Inquiry
Mouse	EYA3-2911M	Recombinant Mouse EYA3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	EYA3-2911M-B	Recombinant Mouse EYA3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	EYA3-1526R	Recombinant Rhesus monkey EYA3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	EYA3-1351R-B	Recombinant Rhesus Macaque EYA3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	EYA3-1351R	Recombinant Rhesus Macaque EYA3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	EYA3-4993Z	Recombinant Zebrafish EYA3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EYA3 Related Articles

EYA3 involved in several pathways and played different roles in them. We selected most pathways EYA3 participated on our site, such as DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with EYA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
DNA Double Strand Break Response	BARD1;UIMC1;BAZ1B;BRCC3;RNF168;BABAM1;TP53BP1;EYA3;RAD50
DNA Double-Strand Break Repair	UIMC1;TIPIN;TP53BP1;CLSPN;RAD9B;GEN1;TDP2B;EYA2;UBE2V2
DNA Repair	RNF111;POLD3;COPS3;MGMT;ERCC8;BRE;WRN;PPP4R2B;COPS7B
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	EYA3;EYA4;KDM4B;KDM4A;BAZ1B;EYA2

EYA3 has several biochemical functions, for example, chromatin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EYA3 itself. We selected most functions EYA3 had, and list some proteins which have the same functions with EYA3. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	GATA5;TRIM37;SP3;CITED1;DLX2;TOP2A;ERCC6;ANKRD17;HMGA1
metal ion binding	ZFP326;ZNF503;EME1;DGKE;WDFY2;RNF150A;WBP7;ZNF728;TIMP1
protein binding	NCAPH2;POLH;MAP2K4;NACC2;HIST1H2BB;DYRK2;CCDC24;LATS2;MACROD1
protein tyrosine phosphatase activity	CDC25B;PTPRK;UBASH3B;DUSP6;DUSP23;PTPRNA;DUSP22;MTMR4;PTPN9
protein tyrosine/serine/threonine phosphatase activity	RNGTT;SSH3;MTMR2;DUSP10;DUSP22;EYA3;SGPP2;CDC14A;DUSP5

EYA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EYA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EYA3.

CRK; ZDHHC17

Majumdar, G; Rani, S; et al. Hypothalamic gene switches control transitions between seasonal life history states in a night-migratory photoperiodic songbird. MOLECULAR AND CELLULAR ENDOCRINOLOGY 399:110-121(2015).

Ashbrook, DG; Delprato, A; et al. Transcript co-Variance With Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor Cell proliferation in the adult hippocampus. FRONTIERS IN NEUROSCIENCE 8:-(2014).