Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

EYA4

Official Full Name

eyes absent homolog 4
Overview

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant nonsyndromic sensorineural 10 locus. Defects in this gene are also associated with dilated cardiomyopathy 1J. Three transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms

EYA4; eyes absent homolog 4 (Drosophila); CMD1J, DFNA10, eyes absent (Drosophila) homolog 4; eyes absent homolog 4; dJ78N10.1 (eyes absent); CMD1J; DFNA10;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EYA4-3595H	Recombinant Human EYA4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EYA4-6490HCL	Recombinant Human EYA4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	EYA4-4459HF	Recombinant Full Length Human EYA4 Protein, GST-tagged	In Vitro Cell Free System	GST	616 amino acids	Inquiry
Zebrafish	EYA4-8371Z	Recombinant Zebrafish EYA4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EYA4 Related Articles

EYA4 involved in several pathways and played different roles in them. We selected most pathways EYA4 participated on our site, such as DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with EYA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
DNA Double Strand Break Response	BABAM1;UIMC1;RAD50;THRSP;CHEK2;RNF168;UBE2V2;SMARCA5;KDM4B
DNA Double-Strand Break Repair	PPP4CA;FUZ;EYA3;EME2;PAXIP1;KDM4A;RIF1;TDP2;FAM175A
DNA Repair	ASCC3;MCRS1;TOPBP1;FAM175A;RAD9;PARP2;DNA2;TDP2;CHD1L
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	EYA4;EYA2;EYA3;KDM4A;KDM4B;BAZ1B

EYA4 has several biochemical functions, for example, metal ion binding, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EYA4 itself. We selected most functions EYA4 had, and list some proteins which have the same functions with EYA4. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	EXT1B;LACTB2;DNMT3B;GDPD2;PRDM12;ZNF621;POLM;DNAJA3;ZNF483
protein binding	THBS4;RYK;KIAA1958;C21orf7;NUPL1;CAMK2A;BRD3;ARRB2;FHOD1
protein tyrosine phosphatase activity	PTPN1;PTPRK;MTMR7;PTPN3;DUSP22B;DUSP16;PTEN;PTPN22;PTPN2B

EYA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EYA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EYA4.

Tan, MX; Shen, XF; et al. Identification of I411K, a novel missense EYA4 mutation causing autosomal dominant non-syndromic hearing loss. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1467-1472(2014).

Hou, X; Peng, JX; et al. DNA Methylation Profiling Identifies EYA4 Gene as a Prognostic Molecular Marker in Hepatocellular Carcinoma. ANNALS OF SURGICAL ONCOLOGY 21:3891-3899(2014).