Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

EZH2

  • Official Full Name

    enhancer of zeste homolog 2 (Drosophila)

  • Overview

    This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
  • Synonyms

    EZH2; enhancer of zeste homolog 2 (Drosophila); WVS; ENX1; EZH1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; histone-lysine N-methyltransferase EZH2; lysine N-methyltransferase 6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • Flag|His
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Flag
  • His|GST
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EZH2-3948H Active Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
Human EZH2-165H Active Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-173H Active Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-161H Active Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-285H Recombinant Human EZH2 Protein, GST-tagged Insect Cell GST
Human EZH2-166H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-174H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-170H Recombinant Human EZH2 Complex protein, His-tagged Insect Cell His 2–end (all components)
Human EZH2-542H Recombinant Human EZH2 Mammalian Cell His
Human EZH2-179H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (EZH2 and EED)
Human EZH2-28H Recombinant Human EZH2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EZH2-175H Recombinant Human EZH2 protein, His-tagged Insect Cell His 2–end (all components)
Human EZH2-162H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-182H Recombinant Human EZH2(Y641C) protein, GST-tagged Insect Cell GST
Human EZH2-171H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-177H Recombinant Human EZH2 Complex protein, His/GST-tagged Insect Cell His/GST 2–end (EZH2, RbAp48), 1–end (SUZ12)
Human EZH2-167H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-163H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-172H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-183H Recombinant Human EZH2(Y641H) protein, GST-tagged Insect Cell GST
Human EZH2-169H Recombinant Human EZH2 Complex protein, His-tagged Insect Cell His 2–end (all components)
Human EZH2-164H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag 2–end (all components)
Human EZH2-998H Recombinant Human EZH2, His-GST-tagged Sf9 Insect Cell His/GST
Human EZH2-42H Recombinant Human EZH2 Protein, His-tagged E.coli His C-term-306aa
Human EZH2-176H Recombinant Human EZH2 protein, His-tagged Insect Cell His 2–end (all components)
Human EZH2-29H Recombinant Human EZH2 Protein, GST-tagged Wheat Germ GST
Human EZH2-29233TH Recombinant Human EZH2, His-tagged E.coli His
Human EZH2-82H Recombinant Human EZH2 Complex protein, His-tagged Insect Cell Flag/His Full length
Human EZH2-184H Recombinant Human EZH2(Y641N) protein, GST-tagged Insect Cell GST
Human EZH2-6487HCL Recombinant Human EZH2 293 Cell Lysate HEK293 N/A
Human EZH2-45H Recombinant Human EZH2 protein, His-tagged E.coli His Glu51~Phe285
Human EZH2-65HFL Active Recombinant Full Length Human EZH2 Protein, C-Flag-tagged Mammalian cells Flag
Human EZH2-48H Recombinant Human EZH2 protein, His-tagged E. coli 158-261 aa
Human EZH2-46H Recombinant Human EZH2 Protein, His-tagged E.coli His
Human EZH2-47H Recombinant Human EZH2 protein, His-tagged E.coli His Arg494~Val737
Human EZH2-879H Recombinant Human EZH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EZH2-1826H Recombinant Human EZH2 protein, GST-tagged E.coli GST 158-261 aa
Human EZH2-2905H Recombinant Human EZH2 Protein (Met1-IIe370), N-GST tagged E.coli N-GST Met1-IIe370
Human EZH2-2486H Recombinant Human EZH2 protein, His-tagged E.coli His 158-261 aa
Human EZH2-2907H Recombinant Human EZH2 Protein (Arg608-Pro746), N-His tagged E.coli N-His Arg608-Pro746
Human EZH2-2906H Recombinant Human EZH2 Protein (Asn371-Pro746), N-GST tagged E.coli N-GST Asn371-Pro746
Human EZH2-1003HF Recombinant Full Length Human EZH2 Protein, GST-tagged In Vitro Cell Free System GST 751 amino acids
Human EZH2-2908H Recombinant Human EZH2 Protein E.coli Tag Free
Human EZH2-879H-B Recombinant Human EZH2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ezh2-991M Recombinant Mouse Ezh2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque EZH2-1528R Recombinant Rhesus monkey EZH2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EZH2-1353R Recombinant Rhesus Macaque EZH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EZH2-1353R-B Recombinant Rhesus Macaque EZH2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish EZH2-4654Z Recombinant Zebrafish EZH2 Mammalian Cell His
Kit-1723 EZH2 (A677G) Chemiluminescent Assay Kit N/A
Kit-1724 EZH2 (Y641F) Chemiluminescent Assay Kit N/A
Kit-1725 EZH2 (Y641N) Chemiluminescent Assay Kit N/A
Kit-1726 EZH2 Chemiluminescent Assay Kit N/A
Kit-1727 EZH2 Homogeneous Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EZH2 Related Articles
  • EZH2 Related Research Area

EZH2 involved in several pathways and played different roles in them. We selected most pathways EZH2 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EZH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MicroRNAs in cancerTGFB2;PIK3CA;MCL1;CCND1;GLS;ABCC1;HDAC1;PDGFRA;MAPK1

EZH2 has several biochemical functions, for example, DNA binding, chromatin DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EZH2 itself. We selected most functions EZH2 had, and list some proteins which have the same functions with EZH2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZFPM1;ANO9A;SMAD9;RAG2;SIX1A;HIF1AL;ZBTB9;KAT6A;PRDM2
chromatin DNA bindingH1F0;HIST1H1D;XBP1;NOTCH1;RARA;RELA;INSM1B;H2AFY2;H2AFY
chromatin bindingLRWD1;DNMT3B;ACTL6A;EZH2;CDC45;CAPNS2;TCF7L2;RERE;CTBP2
core promoter bindingNKX2-1;GTF2B;SFPQ;NEUROG3;KLF4;ARNTL;MYOD1;INSM1B;GADD45A
histone methyltransferase activityEZH2;SUV39H1;PRMT1;PRMT2;CARM1;PRMT6;SUZ12;PRDM13;EED
histone methyltransferase activity (H3-K27 specific)WHSC1L1;EZH2;EHMT2;EHMT1
histone-lysine N-methyltransferase activityWHSC1L1;MLL1;EHMT2;SMYD2A;SETDB1A;SETD7;SUV39H1;SUV39H1A;SETD8
protein bindingMSTN;CEP350;FBXO6;TRIM39;TRAF1;PLLP;ZNF224;UQCRB;TELO2
protein-lysine N-methyltransferase activitySMYD2A;AAAS;PRDM12;FAM86A;IRF4;SETD8;VCPKMT;EHMT2;PRDM11

EZH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EZH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EZH2.

SUZ12; EED

Alberghini, F; Petrocelli, V; et al. An epigenetic view of B-cell disorders. IMMUNOLOGY AND CELL BIOLOGY 93:253-260(2015).
Floris, I; Descamps, B; et al. Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:664-674(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is EZH2 overexpression associated with cancer progression? 11/20/2019

EZH2 overexpression is associated with promoting tumor cell proliferation, invasion, and metastasis, leading to cancer progression.

Are there any non-oncological clinical applications of EZH2? 07/29/2019

EZH2 has been implicated in various non-oncological conditions, including cardiovascular diseases and neurodegenerative disorders.

What are the potential side effects of EZH2 inhibitors in clinical use? 03/15/2017

Potential side effects may include hematological toxicity, gastrointestinal issues, and liver enzyme elevation.

How can EZH2 be targeted for cancer therapy? 08/17/2016

Small molecule inhibitors of EZH2 have been developed and are being investigated as potential cancer therapies.

Are there any prognostic implications of EZH2 expression in cancer patients? 08/15/2016

High EZH2 expression has been associated with poor prognosis in several cancer types.

Customer Reviews (3)

Write a review
Reviews
10/17/2022

    The versatility of the EZH2 protein is truly remarkable, as it can be employed across a wide range of applications in my research.

    03/14/2018

      In addition to its outstanding quality, the manufacturer of the EZH2 protein offers excellent technical support that can effectively address any challenges I may encounter.

      02/27/2018

        Their dedicated team of experts is readily available to provide guidance and assistance, ensuring a seamless integration of the EZH2 protein into my experimental setup.

        Ask a Question for All EZH2 Products

        Required fields are marked with *

        My Review for All EZH2 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends