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Efna1

  • Official Full Name

    ephrin-A1

  • Overview

    This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system
  • Synonyms

    EFNA1; ephrin-A1; EPLG1, TNFAIP4; ECKLG; LERK1; TNF alpha-induced protein 4; ligand of eph-related kinase 1; immediate early response protein B61; eph-related receptor tyrosine kinase ligand 1; tumor necrosis factor alpha-induced protein 4; tumor necrosis; B61; EFL1; EPLG1; LERK-1; TNFAIP4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • hFc
  • His
  • Fc|His
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EFNA1-150H Recombinant Human Ephrin-A1 E.coli N/A
Human EFNA1-357H Active Recombinant Human EFNA1 Protein, His-tagged HEK293 His Met 1-Ser182
Human EFNA1-2238H Recombinant Human EFNA1, His tagged Human Cell His
Human EFNA1-355H Recombinant Human EFNA1 Protein, Fc-tagged HEK293 Fc
Human EFNA1-2060H Recombinant Human Ephrin-A1, Fc Chimera Mammalian Cell Fc
Human EFNA1-3096H Recombinant Human EFNA1 Protein, GST-tagged Wheat Germ GST
Human EFNA1-1279H Recombinant Human Ephrin-A1, His-tagged Human His
Human EFNA1-2326H Recombinant Human EFNA1, Fc-His tagged Human Cell Fc/His
Human EFNA1-4190H Recombinant Human EFNA1 protein, His-tagged E.coli His
Human EFNA1-28470TH Recombinant Human EFNA1, His-tagged E.coli His 164 amino acids
Human EFNA1-28581TH Recombinant Human EFNA1 Wheat Germ N/A 205 amino acids
Human EFNA1-2594HCL Recombinant Human EFNA1 cell lysate Human Cell N/A
Human EFNA1-1561H Recombinant Human EFNA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EFNA1-328H Active Recombinant Human EFNA1 protein, hFc-tagged HEK293 hFc Met1-Ser182
Human EFNA1-229H Recombinant Human EFNA1 Protein, Fc-tagged HEK293 Fc 205
Human EFNA1-136HF Recombinant Full Length Human EFNA1 Protein In Vitro Cell Free System 205 amino acids
Human EFNA1-4215HF Recombinant Full Length Human EFNA1 Protein, GST-tagged In Vitro Cell Free System GST 205 amino acids
Human EFNA1-1407H Recombinant Human EFNA1 protein, Fc-tagged HEK293 Fc Asp19-Ser182
Human EFNA1-2032H Recombinant Human EFNA1 Protein (Asp19-Ser182), N-His tagged E.coli N-His Asp19-Ser182
Human EFNA1-1386H Recombinant Human EFNA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EFNA1-3265H Recombinant Human EFNA1 Protein (Asp19-Ser182), C-His tagged Mammalian cells C-His Asp19-Ser182
Human EFNA1-301377H Recombinant Human EFNA1 protein, GST-tagged E.coli GST Asp56-Ser105
Human EFNA1-3264H Recombinant Human EFNA1 Protein (Asp19-Ser182), C-Fc tagged Mammalian cells C-Fc Asp19-Ser182
Human EFNA1-2836H Recombinant Human EFNA1 protein, His-SUMO-tagged E.coli His-SUMO 19-182aa
Mouse Efna1-425M Active Recombinant Mouse Ephrin A1, His-tagged Mammalian cells His
Mouse Efna1-3264M Active Recombinant Mouse Efna1 protein(Met1-Ser182), hFc-tagged HEK293 C-hFc Met1-Ser182
Mouse Efna1-1730M Recombinant Mouse Ephrin A1, Fc-His Mammalian cells Fc/His
Mouse Efna1-3314M Active Recombinant Mouse Efna1 protein(Met1-Ser182), His-tagged HEK293 C-His Met1-Ser182
Mouse EFNA1-2177MCL Recombinant Mouse EFNA1 cell lysate Human Cell N/A
Mouse Efna1-159M Recombinant Mouse Efna1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EFNA1-1382M Recombinant Mouse EFNA1 Protein, Fc/His-tagged HEK293 Fc/His
Mouse Efna1-159M-B Recombinant Mouse Efna1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Efna1-2753M Recombinant Mouse Efna1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat EFNA1-2024R Recombinant Rat EFNA1 Protein Mammalian Cell His
Rat Efna1-7438R Active Recombinant Rat Efna1 protein(Met1-His181), His-tagged HEK293 C-His Met1-His181
Rat EFNA1-1514RCL Recombinant Rat EFNA1 cell lysate Human Cell N/A
Rat EFNA1-469R Recombinant Rat EFNA1 Protein (18-182 aa), GST-tagged E.coli GST 18-182 aa
Rat Efna1-2837R Recombinant Rat Efna1 protein, His-tagged E.coli His 18-182aa
Rat EFNA1-1681R-B Recombinant Rat EFNA1 Protein Pre-coupled Magnetic Beads HEK293
Rat EFNA1-1383R Recombinant Rat EFNA1 Protein (18-182 aa), His-tagged Yeast His 18-182 aa
Rat EFNA1-1681R Recombinant Rat EFNA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Efna1 Related Articles
  • Efna1 Related Research Area

What is EFNA1 protein?

EFNA1 (ephrin A1) gene is a protein coding gene which situated on the long arm of chromosome 1 at locus 1q22. This gene encodes a member of the ephrin (EPH) family called EFNA1, also known as Ephrin A1 (EphA1), a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage. Human Ephrin A1 binds to the receptor tyrosine kinase EphA2, EphA4, EphA5, EphA6 and EphA7. Also binds with low affinity to EphA1. The EFNA1 protein is consisted of 205 amino acids and its molecular mass is approximately 23.8 kDa.

What is the function of EFNA1 protein?

Ephrin-A1 plays an important role in the development of ephrin-A1, regulating axonal guidance, synaptic formation and nerve cell migration. In adult tissues, Ephrin-A1 also plays a key role in processes such as nervous system maintenance and repair, angiogenesis, immune system and cancer development. In addition, Ephrin-A1 can also interact with other signaling pathways and influence cellular behavior. For example, interactions with the Wnt signaling pathway can influence cell fate decisions and embryonic development. Interaction with the TGF-β signaling pathway can regulate cell migration and epithelial mesenchymal transformation.

EFNA1-7.jpg

Fig1. (D) EPHA2/ephrin-A1 induce tumor growth. (Stavros P Papadakos, 2023)

EFNA1 Related Signaling Pathway

After binding to Eph receptor, Ephrin-A1 could trigger downstream signal transduction pathways including MAPK, PI3K/AKT and Rho family GTPase signaling pathways, which were involved in multiple biological processes such as cell proliferation, migration, adhesion, differentiation and apoptosis. When Ephrin-A1 protein activated EphA receptor, tyrosine kinase activity in EphrA receptor was inhibited, mediating the change of cell attachment and growth anchoring.

EFNA1 Related Diseases

Several studies have suggested that abnormal expression of Ephrin-A1 is associated with the development and metastasis of tumors like breast cancer and gastric cancer. In addition, Ephrin-A1 has been found to play an important role in neurological diseases like glioblastoma, cardiovascular diseases and inflammatory diseases.

Bioapplications of EFNA1

Ephrin-A1 plays an important role in tumorigenesis and development, and several antibodies and small molecule inhibitors targeting Eph receptors are currently in preclinical or clinical trials.

Case Study 1: Pitna Kim, 2019

EFNA1-3.jpg

Fig1. PI-PLC sensitivity of membrane-associated GPI-APs in schizophrenia.

Case Study 2: Yi Wang, 2016

EFNA1-4.jpg

Fig2. Boyden chamber staining of EPCs' chemotaxis to HCC cells with different EphA1 levels, Asterisks indicate significant differences (**P < 0.01, ***P < 0.001) with respect to the corresponding control.

EFNA1-5.jpg

Fig1. EphA1 improves the inflammatory responses and neuropathological changes of the PD model in vivo and in vitro through the CXCL12/CXCR4 signaling pathway. (Jianjun Ma, 2021)

EFNA1-6.jpg

Fig2. Basic molecular structure of the EPH/ephrin signaling compartment. In the plasma membrane, ephrin-A ligands are hooked by a glycosylphosphatidylinositol (GPI) anchor, although they can also activate distant EPH receptors. (Stavros P Papadakos, 2023)

Efna1 involved in several pathways and played different roles in them. We selected most pathways Efna1 participated on our site, such as Arf6 signaling events, Axon guidance, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efna1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arf6 signaling eventsEGFR;KIF13B;ADAP1;IPCEF1;AGTR1;EGF;ADRB2;FBXO8;EPHA2
Axon guidanceLRRC4C;COL9A1B;SLIT2;DUSP7;SPNA1;NETO2;SEMA3A;ACTR2;PEBP1
Developmental BiologyCOL6A3;DUSP4;GPC1B;EPHA2;DUSP10;CFL1;KALRN;MYL12A;MED15
EPH-Ephrin signalingEPHB4A;ARPC1B;ARPC4;EFNB3;EFNA1B;EPHB4B;CLTB;ARPC1A;ACTR2
EPH-ephrin mediated repulsion of cellsEFNA2;EFNB2A;EPHA2A;AP2A2;EFNB1;EFNB3B;EPHA10;EFNA1A;EPHB4A
EPHA forward signalingBLK;EFNA5;EFNA1;EPHA2;EFNA3;EFNA2;CRKL;ARHGEF15
EPHA-mediated growth cone collapseEPHA10;EFNA2;EPHA2A;EFNA1B;EPHA4A;EFNA4;EFNA5;EFNA1A;EPHA2
EPHA2 forward signaling

Efna1 has several biochemical functions, for example, ephrin receptor binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Efna1 itself. We selected most functions Efna1 had, and list some proteins which have the same functions with Efna1. You can find most of the proteins on our site.

Function Related Protein
ephrin receptor bindingEFNA5;CDK5R1;NTRK3;CHN1;EFNA2A;GRB2;ANKS1B;EFNA4;CDK5
protein bindingREST;C16orf79;CD2;SAE1;MSH2;CUBN;KCTD17;FXYD7;DYNLT3
receptor bindingARRB2;LGI1;FIS1;ADAM10;LEPROT;APLN;IL29;CNPY3;CD200

Efna1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efna1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efna1.

EPHA2; PPBP; XRCC6; EEF1G; SUMO2; KAT5

Miao, H; Gale, NW; et al. EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties. ONCOGENE 34:558-567(2015).
McKinney, N; Yuan, LP; et al. EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma. JOURNAL OF NEURO-ONCOLOGY 121:109-118(2015).
  • Q&As
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Q&As (5)

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Can EFNA1 be a target for therapeutic interventions in cancer treatment? 05/06/2021

Yes, EFNA1 is being investigated as a potential therapeutic target in cancer treatment, aiming to develop drugs that modulate its activity.

Are there diagnostic applications for EFNA1 in cancer detection? 01/15/2021

Researchers are exploring the use of EFNA1 as a biomarker for cancer detection, with studies suggesting its potential as a diagnostic tool.

How does EFNA1 interact with the Eph receptors, and what is the significance of this interaction? 04/16/2019

EFNA1 binds to Eph receptors, initiating cell signaling pathways that regulate various cellular processes, making this interaction crucial for normal physiological functions.

How does EFNA1 impact cancer research and treatment? 02/02/2018

EFNA1 is implicated in cancer progression, influencing cell migration and invasion. Understanding its role can potentially lead to targeted therapies for certain cancers.

Are there any neurological disorders associated with EFNA1 dysregulation? 10/26/2016

Dysregulation of EFNA1 has been linked to certain neurological disorders, including Alzheimer's disease and neurodevelopmental disorders.

Customer Reviews (3)

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Reviews
08/15/2019

    Their prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.

    04/04/2019

      Its purity, stability, and consistency are unparalleled, ensuring reliable and reproducible results in my research.

      11/22/2016

        This protein has proven to be an invaluable asset in my experiments, enabling accurate and precise measurements with exceptional sensitivity.

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