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ERAP1

  • Official Full Name

    endoplasmic reticulum aminopeptidase 1

  • Overview

    ARTS1/Adipocyte-derived leucine aminopeptidase (A-LAP) is a member of the M1 family of zinc metallopeptidases. A-LAP is upregulatable by gamma interferon and trims N-terminal lysine, leucine, tyrosine and asparagines residues when they are not followed by
  • Synonyms

    ERAP1; endoplasmic reticulum aminopeptidase 1; A LAP; adipocyte derived leucine aminopeptidase; aminopeptidase regulator of TNFR1 shedding; ARTS 1; ERAAP1; KIAA0525; PILS AP; puromycin insensitive leucyl specific aminopeptidase; aminopeptidase PILS; adipo;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ERAP1-532H Active Recombinant Human ERAP1 Protein, His-tagged Mammalian cells His
Human ARTS-1-873H Recombinant Human ARTS-1 protein, GST-tagged Wheat Germ GST
Human ERAP1-2119H Recombinant Human ERAP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ERAP1-4254H Recombinant Human ERAP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ERAP1-5838H Recombinant Human ERAP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ERAP1-855H Recombinant Human ERAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ERAP1-665HFL Recombinant Full Length Human ERAP1 Protein, C-Flag-tagged Mammalian cells Flag
Human ERAP1-855H-B Recombinant Human ERAP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ERAP1-5276M Recombinant Mouse ERAP1 Protein Mammalian Cell His
Mouse ERAP1-2101M Recombinant Mouse ERAP1 Protein (731-930 aa), His-Myc-tagged E.coli His/Myc 731-930 aa
Mouse ERAP1-2840M Recombinant Mouse ERAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Erap1-2851M Recombinant Mouse Erap1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ERAP1-2840M-B Recombinant Mouse ERAP1 Protein Pre-coupled Magnetic Beads HEK293
Rat ERAP1-2132R Recombinant Rat ERAP1 Protein Mammalian Cell His
Rat ERAP1-1789R Recombinant Rat ERAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ERAP1-1789R-B Recombinant Rat ERAP1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ERAP1 Related Articles
  • ERAP1 Related Research Area

ERAP1 involved in several pathways and played different roles in them. We selected most pathways ERAP1 participated on our site, such as Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Class I MHC mediated antigen processing &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemUBA5;DCTN6;PTBP3;SIGLEC9;CD200R3;ACTR1B;LRR1;DNM2;UBE2L6
Antigen Presentation: Folding, assembly and peptide loading of class I MHCSEC23A;ERAP1;ERAP2;SEC24A;B2ML
Class I MHC mediated antigen processing &ampTRIM50;TRIM39;ASB18;CTSL2;B2ML;SH3RF1;CYBA;RNF182;LRR1
presentationBLMH;CMTM2A;RNF144B;UBE2U;RNF123;CTSL1;UBR1;VPRBP;ASB11
Immune SystemPELI1;TREML1;KLRB1F;NLRP4E;TPP2;BTR18;UBE2J2;MX2;TIRAP

ERAP1 has several biochemical functions, for example, aminopeptidase activity, interleukin-1, Type II receptor binding, interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERAP1 itself. We selected most functions ERAP1 had, and list some proteins which have the same functions with ERAP1. You can find most of the proteins on our site.

Function Related Protein
aminopeptidase activityMETAP2A;DPP9;ERAP2;BLMH;METAP2;LTA4H;Npepo;RNPEP;Ctsl
interleukin-1, Type II receptor bindingIL1RN;ERAP1
interleukin-6 receptor bindingADAM17;PYCARD;ERAP1;CNTF;IL6
metalloaminopeptidase activityRNPEPL1;LTA4H;XPNPEP1;ANPEPA;LNPEP;ERAP2;METAP2B;ENPEP;Npepo
metalloexopeptidase activityMETAP1D;DPEP2;METAP2;DPEP3;METAP2B;LAP3;METAP1;NUDT16;ERAP1
peptide bindingNPFFR1L1;CRIP1;PPIA;MAS1;CMA1;PPYR1;PPIB;NPFFR1;NUP98
protein bindingFAM20C;APP;CCND3;RPS20;PEAK1;DDR2;AZIN2;DUSP7;FOXO3
tumor necrosis factor receptor bindingFADD;TNFSF15;TRAF4;FASLG;TNFSF11;TRAF1;CD40LG;TRADD;TNFSF13B
zinc ion bindingCHORDC1;BARD1;ZCCHC17;PRKCBP1L;DMD;APOBEC3F;ZCCHC10;MARCH7;TRIM25

ERAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERAP1.

IL6R; TNFRSF1A; yapH; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

Smith, JA; et al. Update on Ankylosing Spondylitis: Current Concepts in Pathogenesis. CURRENT ALLERGY AND ASTHMA REPORTS 15:-(2015).
Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
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