SPON1
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Official Full Name
spondin 1, extracellular matrix protein
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Overview
SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system. -
Synonyms
SPON1; spondin 1, extracellular matrix protein; f-spondin; VSGP/F-spondin; spondin-1; spondin 1, (f-spondin) extracellular matrix protein; vascular smooth muscle cell growth-promoting factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
SPON1 involved in several pathways and played different roles in them. We selected most pathways SPON1 participated on our site, such as Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPON1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | PMPCB;APEH;TIMM22;ALG14;GPR119;NEU4;CEACAM21;MTX2;HSCB |
| O-glycosylation of TSR domain-containing proteins | ADAMTS18;SPON1A;THSD7A;ADAMTSL5;ADAMTS15;B3GALTL;ADAMTS20;SPON1B;C8orf84 |
| O-linked glycosylation | ADAMTS4;ADAMTS8;ADAMTS15;KCNA6;B3GALTL;GALNT5;MUC15;MUC1;SPON1A |
| Post-translational protein modification | ADAMTS20;ST6GALNAC1.2;ALG10B;MUC5AC;NAPB;DOHH;EID3;ADAMTS18;TRAPPC6BL |
SPON1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPON1 itself. We selected most functions SPON1 had, and list some proteins which have the same functions with SPON1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DPH3;SPRED1;RPL10A;SCO1;ITPRIPL1;NFKB2;ACP1;VGLL2;NFKB1 |
SPON1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPON1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPON1.
APP; APLP1; APLP2; q9wmx2-pro_0000037548
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