F2
-
Official Full Name
coagulation factor II (thrombin)
-
Overview
Thrombin (activated Factor II [IIa]) is a coagulation protein that has many effects in the coagulation cascade. Thrombin is a serine protease (EC 3.4.21.5) that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. Thrombin is in the form of alpha-thrombin tat is the immediate end product of prothrombin activation, two further thrombin products can be identified, beta- and gamma-thrombin. These are degraded form that may arise from autodigestion of a thrombin preparation. -
Synonyms
F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1;
- Recombinant Proteins
- Native Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Bovine
- Cattle
- Chicken
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- Zebrafish
- Bovine Plasma
- Cattle Blood
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human plasma
- Human Plasma
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Mouse Plasma
- Pig Blood
- Plasma
- Porcine
- Porcine Blood
- Procine Blood
- rat plasma
- Rat plasma
- Wheat Germ
- Yeast
- C
- His
- Myc
- DDK
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- His|T7
- SUMO
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- F2 Related Articles
- F2 Related Gene Family
- F2 Related Research Area
F2 involved in several pathways and played different roles in them. We selected most pathways F2 participated on our site, such as Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with F2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Neuroactive ligand-receptor interaction | LPAR2;LTB4R2;GABRA6;DRD4A;P2RX7;OXTR;GRIN1;GLRA1;GHSRA |
Complement and coagulation cascades | C3;SERPINE1;C4BP;C2;PROC;KLKB1;C1R;C5;C1QB |
Regulation of actin cytoskeleton | RAF1A;KRAS;TMSB4X;ACTN1;ITGA4;GNG12;MYL9A;FGF13B;FGF13A |
F2 has several biochemical functions, for example, calcium ion binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F2 itself. We selected most functions F2 had, and list some proteins which have the same functions with F2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
calcium ion binding | EFCC1;ANXA3;Shh;GCA;NUCB2A;DLL4;CALM4;PCDH15;PCDH1G18 |
growth factor activity | TFF1;BTC;VEGFC;RABEP2;IGF2A;NTF3;NDP;FGF10A;GDF6 |
protein binding | CCNL1;ZFP110;TTR;NOSIP;ACE2;TBX2A;GADD45G;PSMA7;BUD13 |
receptor binding | HFE;HSD17B4;HMGCL;GUSB;ACOX1;PVRL4;LAMA3;CDH5;SNX17 |
serine-type endopeptidase activity | PRTN3;KEX2;PRSS1;KLK1;CORIN;MMP8;TMPRSS4A;C1R;PRSS21 |
thrombospondin receptor activity | SDC4;F2;CD47 |
F2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F2 here. Most of them are supplied by our site. Hope this information will be useful for your research of F2.
q846v4_staau; anti-thrombin_mus_pe; C1QBP; THBD
- Q&As
- Reviews
Q&As (5)
Ask a questionThe F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.
Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.
The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.
Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.
Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.
Customer Reviews (3)
Write a reviewQuality control is evident. This product ensures accuracy in our studies.
Our lab swears by this protein. Fast shipping is a definite bonus.
Consistently reliable. The shipping speed is appreciated in our fast-paced lab.
Ask a Question for All F2 Products
Required fields are marked with *
My Review for All F2 Products
Required fields are marked with *