FADS2
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Official Full Name
fatty acid desaturase 2
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Overview
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] -
Synonyms
FADS2; fatty acid desaturase 2; D6D; DES6; TU13; FADSD6; LLCDL2; SLL0262; delta-6 desaturase; delta-6-desaturase; delta(6) desaturase; delta-6 fatty acid desaturase; delta(6) fatty acid desaturase; linoleoyl-CoA desaturase (delta-6-desaturase)-like 2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Xenopus laevis (African clawed frog)
- Zebrafish
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- FADS2 Related Articles
FADS2 involved in several pathways and played different roles in them. We selected most pathways FADS2 participated on our site, such as alpha-Linolenic acid metabolism, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FADS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| alpha-Linolenic acid metabolism | PLA2G5;PLA2G12B;ACOX1;ACOX3;PLA2G2E;PLA2G2D;PLA2G4A;FADS2;PLA2G10 |
| Biosynthesis of unsaturated fatty acids | ACOT5;ACOT7;FADS1;Scd1;FADS2;HSD17B12B;ACAA1;HADHAA;TECRB |
| Fatty acid metabolism | Scd2;ACAT1;ACOX1;ACSL1A;CPT1C;ACSL4B;ACAA2;SCDB;PECR |
| PPAR signaling pathway | FADS2;SLC27A1A;ACSL4;GK;LPL;ACSBG2;FABP7B;PPARAB;PPARG |
FADS2 has several biochemical functions, for example, acyl-CoA desaturase activity, oxidoreductase activity, stearoyl-CoA 9-desaturase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FADS2 itself. We selected most functions FADS2 had, and list some proteins which have the same functions with FADS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acyl-CoA desaturase activity | FADS6;FADS2 |
| oxidoreductase activity | CYP2K19;CYP2Y3;DIO3A;CBR2;SDR42E1;CYP2D10;IMPDH1B;RDH7;ADOA |
| stearoyl-CoA 9-desaturase activity | SCD5;FADS2;SCD;Scd1;Scd2 |
FADS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FADS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FADS2.
Hsd3b7
- Q&As
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