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FAHD1

  • Official Full Name

    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

  • Overview

    Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
  • Synonyms

    TNKS2; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-2; PARP 5b; PARP 5c; PARP5B; PARP5C; pART6; TANK2; TNKL; TNKS-2; tankyrase 2; tankyrase II; tankyrase-like protein; tankyrase-related protein; poly [ADP-ribose] polymerase 5B; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; PARP-5b; PARP-5c;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FAHD1-958H Recombinant Human FAHD1, His-tagged E.coli His
Human FAHD1-3651H Recombinant Human FAHD1 Protein, GST-tagged Wheat Germ GST
Human FAHD1-250HCL Recombinant Human FAHD1 lysate HEK293 N/A
Human FAHD1-1141H Recombinant Human FAHD1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FAHD1-960H Recombinant Human FAHD1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FAHD1-4439HF Recombinant Full Length Human FAHD1 Protein, GST-tagged In Vitro Cell Free System GST 47 amino acids
Human FAHD1-3013H Recombinant Human FAHD1 protein, His-tagged E.coli His 28-226 aa
Mouse FAHD1-5437M Recombinant Mouse FAHD1 Protein Mammalian Cell His
Mouse FAHD1-2938M-B Recombinant Mouse FAHD1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fahd1-2907M Recombinant Mouse Fahd1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FAHD1-2938M Recombinant Mouse FAHD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FAHD1-2198R Recombinant Rat FAHD1 Protein Mammalian Cell His
Rat FAHD1-1855R Recombinant Rat FAHD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FAHD1-1855R-B Recombinant Rat FAHD1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FAHD1-1544R Recombinant Rhesus monkey FAHD1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FAHD1-1369R Recombinant Rhesus Macaque FAHD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FAHD1-1369R-B Recombinant Rhesus Macaque FAHD1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FAHD1-2873Z Recombinant Zebrafish FAHD1 Mammalian Cell His
Chicken FAHD1-5116C Recombinant Chicken FAHD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FAHD1 involved in several pathways and played different roles in them. We selected most pathways FAHD1 participated on our site, such as Tyrosine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAHD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Tyrosine metabolismADH2-2;COMTB;TAT;HPDA;DBH;GOT1;AOX1;IL4I1;ALDH3B1
Metabolic pathwaysPGAM2;Cel;PGP;NMNAT1;GALCB;AOX4;POLR2C;PIGL;PAICS

FAHD1 has several biochemical functions, for example, acetylpyruvate hydrolase activity, acylpyruvate hydrolase activity, fumarylpyruvate hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FAHD1 itself. We selected most functions FAHD1 had, and list some proteins which have the same functions with FAHD1. You can find most of the proteins on our site.

Function Related Protein
acetylpyruvate hydrolase activity
acylpyruvate hydrolase activity
fumarylpyruvate hydrolase activity
metal ion bindingZNF443;MOBKL1A;Car8;CCC2;GALNS;NRP1A;PRKCHB;ZFY2;ZFP426
oxaloacetate decarboxylase activityME2;ME1;ME3;FAHD1

FAHD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAHD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FAHD1.

PPAP2A; EXOSC4; MME

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