FAP
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Official Full Name
fibroblast activation protein, alpha
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Overview
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] -
Synonyms
FAP; fibroblast activation protein, alpha; FAPA; DPPIV; seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Cynomolgus
- Human
- Monkey
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Insect cells
- Mammalian cells
- NS0
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- DYKDDDDK
- Fc
- Flag
- GST
- hFc
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- MYC
- N/A
- N
- 6×His
- Involved Pathway
- Protein Function
- Interacting Protein
- FAP Related Articles
- FAP Related Research Area
FAP involved in several pathways and played different roles in them. We selected most pathways FAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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FAP has several biochemical functions, for example, dipeptidyl-peptidase activity, endopeptidase activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAP itself. We selected most functions FAP had, and list some proteins which have the same functions with FAP. You can find most of the proteins on our site.
Function | Related Protein |
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dipeptidyl-peptidase activity | DPP7;FAP;DPEP1;DPEP2;DPEP3;DPP3;DPP4;DPP8;NAALAD2 |
endopeptidase activity | TPP1;ACE;HTRA3;KLK1B26;SENP3A;PCSK6;PSMA8;PSMA6;ECE1 |
integrin binding | TSPAN4;FN1A;ACTN3;TNN;Tcam1;LAMB1;ECM2;LYN;CXADR |
metalloendopeptidase activity | MMP10;BMP1;ADAM28;ADAMTS15;MMP23BB;ADAM9;MMP16;ADAM8A;ADAMTS4 |
peptidase activity | GZMC;TRY;KLK1B22;SPG7;USP43A;TMPRSS13A;PSMB11;PRSS48;HE2 |
protease binding | COMP;SERPINC1;ECM1;ITGB3;BDKRB2;FLOT1;SERPINA1E;SELL;ALPI |
protein binding | PKD1;LRRK2;ZNF79;BRAP;CD300LH;BMPR1A;SPRY4;TOLLIP;HENMT1 |
protein dimerization activity | ZBED4;MXD1;BTRC;ATP6V1C2;GPR139;HNF1BA;MITFA;KIF9;SLC4A11 |
protein homodimerization activity | CDA;ZFP652;CD247;SEPHS1;FLT3LG;COQ9;CARD8;TARBP2;RAP1GAP |
serine-type endopeptidase activity | KLK10;CFD;RHBDD1;CFB;GZMC;PRSS52;TMPRSS11G;TYSND1;Gzmg |
serine-type peptidase activity | TMPRSS12;PARLA;ENDOU;FURINA;F9B;PLG;Prss32;TPSG1;Gzmd |
FAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAP here. Most of them are supplied by our site. Hope this information will be useful for your research of FAP.
GCG; VIP; GHRH; NPY; GIP; PYY; NPPB; ADCYAP1; TAC1; b3xyc5_sollc
- Q&As
- Reviews
Q&As (5)
Ask a questionFAP can suppress the immune response by modulating the activity of certain immune cells, creating an immunosuppressive tumor microenvironment.
High levels of FAP expression in tumors have been associated with poor prognosis, making it a potential prognostic marker for certain cancers.
Yes, several clinical trials are investigating the safety and efficacy of FAP-targeted therapies in various cancer types.
FAP-targeted therapies are being explored for conditions such as fibrotic diseases and rheumatoid arthritis, extending its potential clinical applications.
Molecular imaging techniques, such as positron emission tomography (PET), can be employed to visualize FAP expression in tumors noninvasively.
Customer Reviews (3)
Write a reviewIt enables accurate detection and quantification of FAP protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.
FAP protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.
FAP protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.
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