faslg
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  • Official Full Name
  • Fas ligand (TNF superfamily, member 6)
  • Background
  • The Fas receptor (FasR) is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is also known as CD95, Apo-1, and tumor necrosis factor receptor superfamily, member 6 (TNFRSf6). FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution are found in most mammals. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).
  • Synonyms
  • FASLG; Fas ligand (TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95 ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; soluble form; APO1L; Apoptosis antigen ligand 1; CD178 antigen; CD95; L CD95L protein; Fas L; Fas ligand; Fasl Fas ligand (TNF superfamily member 6); Generalized lymphoproliferative disease; Gld; TNF superfamily member 6; TNFL6_HUMAN; Fas-L
Cat.#:FASLG-151HTag:Fc
Source (Host):YeastSpecies:Human
Product nameRecombinant Human FASLG, His tagged
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Cat.#:FASLG-15HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG protein, His-tagged
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Cat.#:FASLG-234HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG, C13&N15-labeled
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Cat.#:FASLG-245HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG, Fc-tagged
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Cat.#:FASLG-28165THTag:
Source (Host):Species:Human
Product nameRecombinant Human FASLG
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Cat.#:FASLG-28388THTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG, FLAG-tagged
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Cat.#:FASLG-46HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human FASLG protein, His-tagged
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Cat.#:FASLG-5001HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Fas Ligand (TNF Superfamily, Member 6)
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Cat.#:FASLG-623HTag:His & GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FASLG protein, His & GST-tagged
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Cat.#:FASLG-624HTag:His & S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FASLG protein, His & S-tagged
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Cat.#:FASLG-7108HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FASLG, His-tagged
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Cat.#:FASLG-2274RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FASLG Protein
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Cat.#:Faslg-626RTag:His & GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Faslg protein, His & GST-tagged
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Cat.#:FASLG-514CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FASLG Protein, His-tagged
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Cat.#:FASLG-1645RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FASLG Protein, His-tagged
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Cat.#:FASLG-627RTag:His & T7
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey FASLG protein, His & T7-tagged
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Cat.#:FASLG-3201CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FASLG
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Cat.#:FASLG-3825ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FASLG
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Cat.#:FASLG-1616HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fas ligand (TNF superfamily, member 6)
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Cat.#:Fasl-1736MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Fas Ligand (TNF Superfamily, Member 6)
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Cat.#:FASLG-2424HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG, FLAG-tagged
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Cat.#:FASLG-2703HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FASLG, His-tagged
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Cat.#:FASLG-6324HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FASLG 293 Cell Lysate
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Cat.#:FASLG-5412HTag:His
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human Fas Ligand (TNF superfamily, member 6), His-tagged
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Cat.#:FASLG-5413HTag:N/A
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human Fas Ligand (TNF superfamily, member 6)
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Cat.#:CSC-P0740Tag:
Source (Host):Species:Human
Product nameAnti-Human FASLG MAb Stable Cell Line-CHO
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Cat.#:CSC-P0741Tag:
Source (Host):Species:Human
Product nameAnti-Human FASLG F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0742Tag:
Source (Host):Species:Human
Product nameAnti-Human FASLG scFv Stable Cell Line-CHO
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FASLG Related Articles

Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
Barathan, M; Gopal, K; et al. Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. APOPTOSIS 20:466-480(2015).

FASLG Related Gene Family

TNF