FBP1
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Official Full Name
fructose-1,6-bisphosphatase 1
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Overview
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. -
Synonyms
FBP1; fructose-1,6-bisphosphatase 1; FBP; 6-bisphosphatase 1; 6-bisphosphate 1-phosphohydrolase 1; D fructose 1 6 bisphosphate 1 phosphohydrolase 1; D-fructose-1; EC 3.1.3.11; F16P1_HUMAN; FBP 1; FBPase 1; Fructose 1 6 bisphosphatase 1; Fructose bisphosphatase 1; Fructose-1; Growth inhibiting protein 17; Liver fructose bisphosphatase; OTTHUMP00000021694; fructose-bisphosphatase 1; growth-inhibiting protein 17; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
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- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- His|SUMO|Myc
- DDK
- MYC
- N/A
- N
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- FBP1 Related Articles
- FBP1 Related Research Area
What is FBP1 protein?
FBP1 (fructose-bisphosphatase 1) gene is a protein coding gene which situated on the long arm of chromosome 9 at locus 9q22. Fructose-1,6-bisphosphatase 1(FBP1) is a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. The FBP1 protein is consisted of 338 amino acids and its molecular mass is approximately 36.8 kDa.
What is the function of FBP1 protein?
FBP1 appears to modulate glycerol gluconeogenesis in liver. It is an important regulator of appetite and adiposity. The expression of FBP1 in liver will increase after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus it seems to provide a feedback mechanism to limit weight gain.
Fig1. A schematic diagram illustrates how reduced FBP1 expression upon irradiation leads to glycolysis activation and infiltration of glioblastoma (GBM). (Beomseok Son, 2019)
FBP1 Related Signaling Pathway
The signaling pathways involved in FBP1 (fructose-1, 6-diphosphatase) are gluconeogenesis and glycolysis. In addition, the activity of FBP1 is regulated by many factors, including AMP, Insulin, PPARα, etc. PPARα is a nuclear receptor whose activation can inhibit FBP1 transcription. AMPK is an energy-sensitive kinase whose activity is regulated by changes in the intracellular AMP/ATP ratio. Activated AMPK can inhibit the expression and activity of FBP1, thereby reducing gluconeogenesis.
FBP1 Related Diseases
FBP1 is mainly involved in the metabolic process of glucose. If the function of this enzyme is abnormal, or the expression of FBP1 is low, it is associated with hypoglycemia and metabolic acidosis. And it may affect the normal metabolism of glucose, which may lead to a series of metabolic diseases, such as diabetes and obesity. Other related diseases include glycogen storage disease type I (GSD-I), hepatic insulin resistance and hepatocellular carcinoma (HCC).
Bioapplications of FBP1
FBP1 is widely used in biology, involving many fields such as glucose metabolism, diabetes, drug research and development. By further studying the function and regulatory mechanism of FBP1, we can provide new ideas and methods for the prevention, diagnosis and treatment of related diseases.
High Purity
Fig1. SDS-PAGE (FBP1-3880H) (PROTOCOL for western blot)
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Fig2. SDS-PAGE (FBP1-2335H) (PROTOCOL for western blot)
Case Study 1: Alexander Damanakis, 2022
Fig1. Representative images of immunohistochemistry (IHC) from A FBP1-negative (score 0) and B FBP1-positive (score 3) specimens of esophageal adenocarcinoma from the tissue microarray.
Case Study 2: Bo Wang, 2020
Fig2. MCF-7, T47D, VCaP and PC-3 cells were harvested for western blot after infected with lentivirus expressing control shRNA or FBP1-specific shRNA.
Fig2. A hypothetical model depicting FBP1 repression of PD-L1 expression via the competitive interaction with STAT3. (Bo Wang, 2020)
FBP1 involved in several pathways and played different roles in them. We selected most pathways FBP1 participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | PGM2;DLDH;PCK1;GALM;ADH6;ALDH2.1;G6PC;ADPGK;AKR1A1A |
| Pentose phosphate pathway | PRPS2;TALDO1;PRPS1;GPI1;ALDOA;PRPS1A;ALDOC;RPIA;PRPS1L1 |
| Fructose and mannose metabolism | MPI;TIGARA;C12orf5;ALDOB;PFKP;SORD;AKR1B8;Akr1b3;FBP1B |
| Metabolic pathways | DUT;ATP5F1;GCDHB;PIGP;SDHC;MGAT4B;KYNU;UGT1A7;LIPC |
| Carbon metabolism | ACSS2;TKTB;ACO1;GPT2L;PRPS1L1;SDHDB;PGK1;DLAT;HK3 |
| AMPK signaling pathway | FBP1;AKT2;CFTR;PPP2R1B;PRKAB1;PCK2;MAP3K7;MTOR;TBC1D1 |
| Insulin signaling pathway | FLOT2;ACACB;HK2;PPP1CAB;CALM1A;HKDC1;PRKAB1A;SHC2;INPP5K |
FBP1 has several biochemical functions, for example, AMP binding, fructose 1,6-bisphosphate 1-phosphatase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBP1 itself. We selected most functions FBP1 had, and list some proteins which have the same functions with FBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| AMP binding | PRKAG1;PYGM;CYB5R3;PRPS2;APRT;PRKAG2;PYGL;ACSS2;FBP1 |
| fructose 1,6-bisphosphate 1-phosphatase activity | FBP2;FBP1;FBP1B;FBP1A |
| identical protein binding | VWA1;ALDOA;ATL1;BCAT1;ASS1;TRP63;AGXT2L2;LRP6;EID3 |
| metal ion binding | CYP2J6;ACO1;ZNF766;CCC2;TRIM35-1;CTDSP2;ANTXR2;ZNF333;KLK4 |
| monosaccharide binding | GPR19;Siglece;GPI;FBP1;TALDO1;PGLS;RPIA;GPI1;UPK1A |
| protein binding | MRPL23;ETV5;DIRAS3;ATG16L1;SH2D3A;FOXO1;AGPAT4;AHSA1;MCM10 |
FBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBP1.
BIN1; FBP2; ACTN3; DYNC1I1; BUB1; TLR2
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, alterations in FBP1 expression can serve as a diagnostic biomarker for certain cancers, aiding in early detection.
FBP1 is involved in hepatic gluconeogenesis, and its dysregulation is associated with liver diseases. Understanding its role can guide therapeutic interventions for liver conditions.
Reduced FBP1 activity in cancer cells promotes tumor growth by altering energy metabolism and supporting the increased demand for nutrients.
Studies suggest that FBP1 expression levels may have prognostic value in predicting the outcomes of cancer patients, providing insight into disease progression.
Strategies to modulate FBP1 expression or activity may offer potential therapeutic avenues for managing glucose levels in diabetes.
Customer Reviews (3)
Write a reviewIts purity and consistency are of the highest standards, allowing for precise and reliable results in my research endeavors.
The manufacturer's commitment to excellence is truly commendable, especially when it comes to their outstanding technical support.
The FBP1 Protein is a protein of exceptional quality that surpasses my expectations and fulfills all my experimental requirements.
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