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FBXL5

Official Full Name

F-box and leucine-rich repeat protein 5
Overview

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Synonyms

FBXL5; F-box and leucine-rich repeat protein 5; FBL4; FBL5; FLR1; F-box/LRR-repeat protein 5; F-box protein FBL5; p45SKP2-like protein; F-box protein FBL4/FBL5;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
GST|His
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXL5-12780H	Recombinant Human FBXL5, His-tagged	E.coli	His	1-250a.a.	$319 / 25ug
Human	FBXL5-479H	Recombinant Human FBXL5 Protein, GST-His-tagged	E.coli	GST/His		Inquiry
Human	FBXL5-3907H	Recombinant Human FBXL5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXL5-6310HCL	Recombinant Human FBXL5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FBXL5-5002HF	Recombinant Full Length Human FBXL5 Protein, GST-tagged	In Vitro Cell Free System	GST	691 amino acids	Inquiry
Mouse	FBXL5-5725M	Recombinant Mouse FBXL5 Protein	Mammalian Cell	His		Inquiry
Mouse	FBXL5-3149M	Recombinant Mouse FBXL5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FBXL5-3149M-B	Recombinant Mouse FBXL5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	FBXL5-8468Z	Recombinant Zebrafish FBXL5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FBXL5 Related Articles

FBXL5 involved in several pathways and played different roles in them. We selected most pathways FBXL5 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Association of TriC/CCT with target proteins during biosynthesis	FBXW4;CCT3;CCT8;NOP56;CCT4;TCP1;FBXW9;KIFC3;FKBP9
Chaperonin-mediated protein folding	FBXW2;FBXW9;FBXW4;FKBP9;PFDN4;CCT4;NOP56;PFDN5;CCT6A
Metabolism of proteins	SEC61B;SLC25A13;TRAPPC6BL;C8orf84;PPP6R3;TIMM9;ARSJ;MUC12;IGFBP6B
Protein folding	PFDN1;CCT6A;ARL2;PFDN2;TBCA;PFDN5;TBCD;PFDN6;TBCE

FBXL5 has several biochemical functions, for example, iron ion binding, protein binding, contributes_to ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL5 itself. We selected most functions FBXL5 had, and list some proteins which have the same functions with FBXL5. You can find most of the proteins on our site.

Function	Related Protein
iron ion binding	CYP2AD2;CYP11A1;CYP2P7;CYP2H1;FAXDC2;CYP2B19;CYP46A1.1;CYP2D10;EGLN1
protein binding	SDCBP;GYS1;TLK2;PRPF8;ECE2;FBLIM1;AHCYL2;PDLIM5;LSM6
contributes_to ubiquitin protein ligase activity	FBXL18;UBXN6;FBXL7;FBXL14A;FBXL15;FBXL14;FBXL3;SKP2;CUL2
ubiquitin-protein transferase activity	HECTD1;ANAPC4;UHRF2;UBE2E1;TRAF3;UBE2Q2;UBE2N;LTN1;UBA7

FBXL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL5.

SKP1; ORC4; MYB; PLK1; CSNK2B; EP300; rpoB

Feng, JJ; Wang, JH; et al. High-throughput deep sequencing reveals that microRNAs play important roles in salt tolerance of euhalophyte Salicornia europaea. BMC PLANT BIOLOGY 15:-(2015).

Kawakami, E; Tokunaga, A; et al. The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. MECHANISMS OF DEVELOPMENT 135:31-42(2015).