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FBXO17

Official Full Name

F-box protein 17
Overview

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing of this gene results in 2 transcript variants encoding different isoforms
Synonyms

FBXO17; F-box only protein 17; F-box protein FBG4; F-box only protein 26; F-box protein 17; FBXO26; FBG4; FLJ58300; FBX17; FLJ25205; FLJ11798; FBX26;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXO17-12786H	Recombinant Human FBXO17, His-tagged	E.coli	His	1-278a.a.	$319 / 25ug
Human	FBXO17-3917H	Recombinant Human FBXO17 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXO17-6307HCL	Recombinant Human FBXO17 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FBXO17-5023HF	Recombinant Full Length Human FBXO17 Protein, GST-tagged	In Vitro Cell Free System	GST	287 amino acids	Inquiry
Rat	FBXO17-2289R	Recombinant Rat FBXO17 Protein	Mammalian Cell	His		Inquiry
Rat	FBXO17-1946R	Recombinant Rat FBXO17 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	FBXO17-1946R-B	Recombinant Rat FBXO17 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

FBXO17 involved in several pathways and played different roles in them. We selected most pathways FBXO17 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	CTSE;TREM1;HLA-DQB2;SIGLEC11;VPRBP;SIGLEC7;DCTN6;ASB18;ASB17
Antigen processing: Ubiquitination &amp	TRIM41;RNF34;FBXO27;ASB18;ASB10;RNF19B;RNF144B;RNF182;ARIH2
Proteasome degradation	PJA1;ASB17;WSB1;SPSB4;TRIM63;TRAF7;UBE2L6;CMTM2A;DZIP3
Class I MHC mediated antigen processing &amp	ASB3;SPSB2;LRRC41;ASB11;FBXO17;UBE2U;ASB7;MKRN1;ASB6
presentation	DZIP3;UBA5;LTN1;RNF41;RNF14;ASB4;UBE2L6;ASB18;HUWE1
Immune System	NLRC5;CFHL3;CRCP;RNF25;PPAPDC1A;ASB9;LAT2;RNF34;KIF11
Selenium Metabolism and Selenoproteins	SELT;CREM;DIO2;TXNRD2;MSRB1;SELK;SELENBP1;TRNAU1AP;SP3

FBXO17 has several biochemical functions, for example, glycoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO17 itself. We selected most functions FBXO17 had, and list some proteins which have the same functions with FBXO17. You can find most of the proteins on our site.

Function	Related Protein
glycoprotein binding	FBXO27;EDEM2;FGFR1;FOXRED2;CSNK1D;B2M;RGMA;ACE2;DNAJC5
protein binding	SOX5;ADAMTS3;SEC23IP;GRB7;N4BP2L2;TBATA;INTS3;ASB9;ZNHIT1

FBXO17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO17 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO17.

SKP1; COPS6; COPS5