Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

FBXO22

Official Full Name

F-box protein 22
Overview

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.
Synonyms

FBXO22; F-box protein 22; F box only protein 22; F-box only protein 22; FBX22; FIST domain containing 1; FISTC1; F-box protein FBX22p44; FLJ13986; MGC31799;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXO22-12790H	Recombinant Human FBXO22, GST-tagged	E.coli	GST	104-403a.a.	$319 / 25ug
Human	FBXO22-3921H	Recombinant Human FBXO22 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXO22-480H	Recombinant Human FBXO22 Protein, His-tagged	E.coli	His		Inquiry
Human	FBXO22-6304HCL	Recombinant Human FBXO22 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FBXO22-5026HF	Recombinant Full Length Human FBXO22 Protein, GST-tagged	In Vitro Cell Free System	GST	299 amino acids	Inquiry
Rhesus Macaque	FBXO22-1658R	Recombinant Rhesus monkey FBXO22 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	FBXO22-1482R	Recombinant Rhesus Macaque FBXO22 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	FBXO22-1482R-B	Recombinant Rhesus Macaque FBXO22 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	FBXO22-3236Z	Recombinant Zebrafish FBXO22	Mammalian Cell	His		Inquiry
Chicken	FBXO22-2259C	Recombinant Chicken FBXO22	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

FBXO22 involved in several pathways and played different roles in them. We selected most pathways FBXO22 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

FBXO22 has several biochemical functions, for example, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO22 itself. We selected most functions FBXO22 had, and list some proteins which have the same functions with FBXO22. You can find most of the proteins on our site.

Function	Related Protein
ubiquitin-protein transferase activity	BRCA1;UHRF1;PAX6;RNF5;TRAF2;TRIM56;RNF152;RNF20;TRIM13

FBXO22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO22 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO22.

COPS6; COPS5; NCOR2; midostaurin; SKP1