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FBXO32

Official Full Name

F-box protein 32
Overview

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms

FBXO32; F-box protein 32; F box only protein 32; F-box only protein 32; ATROGIN1; Fbx32; MAFbx; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; Atrophy gene 1; FBX32_HUMAN; fbxo25; FLJ32424; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXO32-3936H	Recombinant Human FBXO32 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXO32-12796H	Recombinant Human FBXO32, GST-tagged	E.coli	GST	C-term-217a.a.	$319 / 25ug
Human	FBXO32-22H	Recombinant Human FBXO32 protein, His-tagged	E.coli	His		Inquiry
Human	FBXO32-28812TH	Recombinant Human FBXO32	Wheat Germ	N/A	210 amino acids	Inquiry
Human	FBXO32-6297HCL	Recombinant Human FBXO32 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FBXO32-237H	Recombinant Human FBXO32 Protein, His-tagged	E.coli	His	Met1~Glu201	$298 / 10ug
Human	FBXO32-3647H	Recombinant Human FBXO32 protein, His-tagged	E.coli	His	1-216 aa	$319 / 25ug
Human	FBXO32-165HF	Recombinant Full Length Human FBXO32 Protein	In Vitro Cell Free System		210 amino acids	Inquiry
Human	FBXO32-3801H	Recombinant Human FBXO32 protein, His-tagged	E.coli	His	50-120 aa	$319 / 25ug
Human	FBXO32-4670HF	Recombinant Full Length Human FBXO32 Protein, GST-tagged	In Vitro Cell Free System	GST	210 amino acids	Inquiry
Mouse	FBXO32-5744M	Recombinant Mouse FBXO32 Protein	Mammalian Cell	His		Inquiry
Mouse	Fbxo32-4916M	Recombinant Mouse Fbxo32 protein, His&Myc-tagged	E.coli	His&Myc	1-355aa	Inquiry
Mouse	FBXO32-3160M-B	Recombinant Mouse FBXO32 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	FBXO32-3160M	Recombinant Mouse FBXO32 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	FBXO32-2295R	Recombinant Rat FBXO32 Protein	Mammalian Cell	His		Inquiry
Rat	FBXO32-1952R-B	Recombinant Rat FBXO32 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	FBXO32-1952R	Recombinant Rat FBXO32 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	FBXO32-1663R	Recombinant Rhesus monkey FBXO32 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	FBXO32-1487R-B	Recombinant Rhesus Macaque FBXO32 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	FBXO32-1487R	Recombinant Rhesus Macaque FBXO32 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	FBXO32-11158Z	Recombinant Zebrafish FBXO32	Mammalian Cell	His		Inquiry
Chicken	FBXO32-2644C	Recombinant Chicken FBXO32	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FBXO32 Related Articles

FBXO32 involved in several pathways and played different roles in them. We selected most pathways FBXO32 participated on our site, such as FoxO family signaling, FoxO signaling pathway, Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO32 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
FoxO family signaling	CSNK1G3;FBXO32;ZFAND5;CSNK1G2;MST1;GADD45A
FoxO signaling pathway	FBXO25;TGFBR1;PDPK1B;INSRA;PLK4;CCND2A;SOS1;SMAD2;AKT3A
Monoamine Transport	HRH3;SYN1;TPH2;UNC13B;SCAMP2;TGFB1I1;FBXO32;DBH

FBXO32 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO32 itself. We selected most functions FBXO32 had, and list some proteins which have the same functions with FBXO32. You can find most of the proteins on our site.

Function	Related Protein
protein binding	TNP1;OLFM3;MRFAP1;PHLDA1;XAGE2;HPSE;MGP;ROR1;LASP1

FBXO32 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO32 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO32.

EIF3F; MYOG; MLH1; SKP1; KDM2A

Ma, L; Shen, CA; et al. EXTRACELLULAR SIGNAL-REGULATED KINASE-MAMMALIAN TARGET OF RAPAMYCIN SIGNALING AND FORKHEAD-BOX TRANSCRIPTION FACTOR 3A PHOSPHORYLATION ARE INVOLVED IN TESTOSTERONE'S EFFECT ON SEVERE BURN INJURY IN A RAT MODEL. SHOCK 43:85-91(2015).

Cappelletti, C; Galbardi, B; et al. Autophagy, Inflammation and Innate Immunity in Inflammatory Myopathies. PLOS ONE 9:-(2014).