FBXW4
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Official Full Name
F-box and WD repeat domain containing 4
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Overview
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. -
Synonyms
FBXW4; F-box and WD repeat domain containing 4; F box and WD 40 domain protein 4 , SHFM3, split hand/foot malformation (ectrodactyly) type 3; F-box/WD repeat-containing protein 4; dactylin; Fbw4; DAC; F box and WD 40 domain containing protein 4; F box and WD 40 domain protein 4; F box and WD repeat domain containing 4; F box/WD repeat containing protein 4; F box/WD repeat protein 4; F-box and WD-40 domain-containing protein 4; FBW 4; FBWD 4; FBWD4; FBXW 4; FBXW4_HUMAN; OTTHUMP00000059175; SHFM 3; SHSF 3; SHSF3; Split hand/foot malformation (ectrodactyly) type; F-box/WD repeat protein 4; F-box and WD-40 domain protein 4; SHFM3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
FBXW4 involved in several pathways and played different roles in them. We selected most pathways FBXW4 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Association of TriC/CCT with target proteins during biosynthesis | CCT4;CCT6A;CCT3;TCP1;NOP56;FBXW2;CCT7;FBXW5;FBXL5 |
Chaperonin-mediated protein folding | TUBA1B;FBXL5;FBXW9;PFDN2;CCT4;PFDN1;CCT7;FBXW2;CCT8 |
Metabolism of proteins | TMED10;MAGT1;CPN1;ASNA1;IGFBP2;PIGK;IGFBP5;SLC34A2A;A4GNT |
Protein folding | TBCB;FBXW5;FBXL5;CCT7;VBP1;PFDN4;PFDN6;FKBP9;TBCE |
FBXW4 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW4 itself. We selected most functions FBXW4 had, and list some proteins which have the same functions with FBXW4. You can find most of the proteins on our site.
Function | Related Protein |
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molecular_function | BOLA3;LFNG;FBXO24;MURCA;IFFO2;C1QL3B;PNPLA4;UBL7B;ETAA1 |
FBXW4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW4.
SKP1; CUL1; CDC37; ECSIT; RNF32; MAST1; SLX4IP
- Q&As
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