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FBXW5

Official Full Name

F-box and WD repeat domain containing 5
Overview

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
Synonyms

FBXW5; F-box and WD repeat domain containing 5; F box and WD 40 domain protein 5; F-box/WD repeat-containing protein 5; DKFZP434B205; Fbw5; MGC20962; F box and WD 40 domain containing protein 5; F box and WD repeat domain containing 5; F-box and WD-40 domain protein 5; WD repeat-containing F-box protein FBW5; F-box and WD-40 domain-containing protein 5; RP11-229P13.10;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXW5-3973H	Recombinant Human FBXW5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXW5-610HCL	Recombinant Human FBXW5 cell lysate		N/A		Inquiry
Human	FBXW5-4717HF	Recombinant Full Length Human FBXW5 Protein, GST-tagged	In Vitro Cell Free System	GST	159 amino acids	Inquiry
Mouse	FBXW5-5779M	Recombinant Mouse FBXW5 Protein	Mammalian Cell	His		Inquiry
Mouse	FBXW5-3179M	Recombinant Mouse FBXW5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FBXW5-3179M-B	Recombinant Mouse FBXW5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	FBXW5-2303R	Recombinant Rat FBXW5 Protein	Mammalian Cell	His		Inquiry
Rat	FBXW5-1960R-B	Recombinant Rat FBXW5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	FBXW5-1960R	Recombinant Rat FBXW5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	FBXW5-12506Z	Recombinant Zebrafish FBXW5	Mammalian Cell	His		Inquiry
Chicken	FBXW5-2397C	Recombinant Chicken FBXW5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FBXW5 Related Articles

FBXW5 involved in several pathways and played different roles in them. We selected most pathways FBXW5 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Association of TriC/CCT with target proteins during biosynthesis	FBXL5;CCT8;CCT5;CCT6A;FBXW9;CCT3;FKBP9;TCP1;FBXW2
Chaperonin-mediated protein folding	PFDN6;TUBB4A;FBXW5;FBXW2;TUBA3D;FBXW4;CCT4;FKBP9;FBXW9
Metabolism of proteins	EEF1G;KLK13;SPON1A;DNAJC24;TBCE;MAN1B1;NAT8;RAB27A;PREB
Protein folding	ARL2;CCT6A;FBXW2;PFDN4;CCT7;PFDN1;SERPINA7;TBCD;PFDN6

FBXW5 has several biochemical functions, for example, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW5 itself. We selected most functions FBXW5 had, and list some proteins which have the same functions with FBXW5. You can find most of the proteins on our site.

Function	Related Protein
protein binding	RP9;ECE1;CAML;ZCCHC11;MTMR14;TAF13;ARHGEF3;GPATCH4;ATP6V0D2
protein kinase binding	GYS1;CALM2;HIF1A;MAP2K3;DPYSL2;SHC1;RACGAP1;MAP2K6;RFFL

FBXW5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW5.

SKP1; TRIM27; KRTAP10-8; KRT31; KRT40; ADAMTSL4

Ha, JY; Kim, JS; et al. Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. JOURNAL OF NEUROCHEMISTRY 129:527-538(2014).

Kim, TY; Jackson, S; et al. CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:16868-16873(2013).