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FBXW8

  • Official Full Name

    F-box and WD repeat domain containing 8

  • Overview

    This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms

    FBXW8; F-box and WD repeat domain containing 8; F box and WD 40 domain protein 8 , F box only protein 29 , FBXO29; F-box/WD repeat-containing protein 8; FBW6; FBW8; FBX29; F box/WD repeat containing protein 8; F box and WD40 domain containing protein 8; F box only protein 29; FBXO29; FBXW6; F-box only protein 29; F-box and WD-40 domain protein 8; F-box and WD-40 domain-containing protein 8;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBXW8-3977H Recombinant Human FBXW8 Protein, GST-tagged Wheat Germ GST
Mouse FBXW8-5781M Recombinant Mouse FBXW8 Protein Mammalian Cell His
Mouse FBXW8-3180M Recombinant Mouse FBXW8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FBXW8-3180M-B Recombinant Mouse FBXW8 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FBXW8-6446Z Recombinant Zebrafish FBXW8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FBXW8 involved in several pathways and played different roles in them. We selected most pathways FBXW8 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisPRPF19;UBE3B;UBE2G2;CUL2;FBXO2;MDM2;ANAPC4;UBOX5;BIRC8

FBXW8 has several biochemical functions, for example, protein binding, contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW8 itself. We selected most functions FBXW8 had, and list some proteins which have the same functions with FBXW8. You can find most of the proteins on our site.

Function Related Protein
protein bindingGRIN1;PHC3;KCNQ5;MAFB;KIAA1609;TOP1;TMEM86B;TMEM190;GSG1
contributes_to ubiquitin-protein transferase activityKBTBD12;FBXL15;UBE2S;DBN1;KLHL9;KLHL7;KBTBD3;DDB2;ERCC8

FBXW8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW8.

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