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FCAR

Official Full Name

Fc fragment of IgA, receptor for
Overview

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms

FCAR; Fc fragment of IgA, receptor for; immunoglobulin alpha Fc receptor; CD89; Fc alpha receptor; FCAR_HUMAN; IgA Fc receptor; OTTHUMP00000068691; OTTHUMP00000068692; OTTHUMP00000068693; OTTHUMP00000068694; OTTHUMP00000068695; OTTHUMP00000068696; OTTHUMP00000068697; OTTHUMP00000068698;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Homo sapiens (Human)
Human
Rat

Source

E.coli
E.coli expression system
HEK293
HEK293T
Human Cell
Human Cells
Insect Cell
Mammalian cells
Wheat Germ

Tag

C
His
Fc
Fc|His
GST
hFc
His|GST
His|T7
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FCAR-3982H	Recombinant Human FCAR Protein, His-tagged	HEK293	His		Inquiry
Human	FCAR-27894TH	Recombinant Human FCAR	Wheat Germ	N/A	110 amino acids	Inquiry
Human	FCAR-666H	Recombinant Human FCAR protein(Met1-Asn227), His-tagged	HEK293	C-His	Met1-Asn227	$623 / 50 µg
Human	FCAR-3983H	Recombinant Human FCAR Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FCAR-6909H	Recombinant Human FCAR protein, His & GST-tagged	E.coli	His/GST	Gln22~Asn227 (Accession # P24071)	Inquiry
Human	FCAR-3040HCL	Recombinant Human FCAR cell lysate	Human Cell	N/A		Inquiry
Human	FCAR-151H	Recombinant Human FCAR Protein, His-tagged	Human Cells	His		Inquiry
Human	FCAR-0969H	Recombinant Human FCAR Protein (Gln22-Asn227), N-GST tagged	E.coli	N-GST	Gln22-Asn227	Inquiry
Human	FCAR-213H	Recombinant Human FCAR Protein, His-tagged	Insect Cell	His	22-227aa	Inquiry
Human	FCAR-2297H	Recombinant Human FCAR Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	FCAR-030H	Recombinant Human FCAR Protein, His-tagged	E.coli	His		Inquiry
Human	FCAR-3634H	Recombinant Human FCAR protein, His-tagged	E.coli	His	22-227 aa	$319 / 25ug
Human	FCAR-2047H	Recombinant Human FCAR Protein, Fc/His-tagged	HEK293	Fc/His	Gln22-Asn227	Inquiry
Human	FCAR-3014H	Recombinant Human FCAR Protein (Gln22-Asn227), C-His-Fc tagged	Mammalian cells	C-His-Fc	Gln22-Asn227	Inquiry
Human	FCAR-459H	Active Recombinant Human FCAR Protein, hFc-tagged	HEK293	hFc	Gln22-Asn227	Inquiry
Human	FCAR-4105H	Recombinant Human FCAR Protein (Met1-Asn227), C-His tagged	Mammalian cells	C-His	Met1-Asn227	Inquiry
Human	FCAR-2644H	Recombinant Human FCAR protein, hFc&His-tagged	HEK293	hFc&His	Gln22-Asn227	Inquiry
Rat	Fcar-6910R	Recombinant Rat Fcar protein, His & T7-tagged	E.coli	His/T7	Thr51~Arg280 (Accession # D3ZRL6)	Inquiry
Rat	Fcar-4080R	Recombinant Rat Fcar, His tagged	Human Cell	His		$623 / 50 µg
Rat	FCAR-1929RCL	Recombinant Rat FCAR cell lysate	Human Cell	N/A		Inquiry
Homo sapiens (Human)	RFL17HF	Recombinant Full Length Human Immunoglobulin Alpha Fc Receptor(Fcar) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (22-287)	Inquiry

Involved Pathway
Protein Function
Interacting Protein

FCAR involved in several pathways and played different roles in them. We selected most pathways FCAR participated on our site, such as Phagosome, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	HLA-F;BMA1;NOS1;CORO1A;HLA-DQA2;RILP;DYNC1I2A;ATP6V1B1;ATP6V1C1B
Staphylococcus aureus infection	FCGR3;HLA-DRA;CFB;PLG;FPR2;SELP;FCGR2B;FCGR1;ITGB2

FCAR has several biochemical functions, for example, IgA binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FCAR itself. We selected most functions FCAR had, and list some proteins which have the same functions with FCAR. You can find most of the proteins on our site.

Function	Related Protein
IgA binding	AMBP;FCAR;IGJ;FCAMR
receptor signaling protein activity	BAG4;RGS14A;NSMAF;RAF1A;Siglece;DCLK1;ADCYAP1;TYROBP;DOK2

FCAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCAR here. Most of them are supplied by our site. Hope this information will be useful for your research of FCAR.