FCER1A
-
Official Full Name
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
-
Overview
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. -
Synonyms
FCER1A; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; FCE1A; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypep;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- hFc
- His
- Fc
- GST
- His (Fc)
- Avi
- His|SUMO
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FCER1A Related Research Area
FCER1A involved in several pathways and played different roles in them. We selected most pathways FCER1A participated on our site, such as Sphingolipid signaling pathway, Phospholipase D signaling pathway, Fc epsilon RI signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCER1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Sphingolipid signaling pathway | BCL2;PIK3R3;RAC3;NFKB1;PLCB2;PRKCB;PPP2R3A;BDKRB2;PIK3R1 |
Phospholipase D signaling pathway | LPAR2;AGPAT5;SHC4;AVPR1A;HRAS;PLCB4;PIK3CG;GAB1;AKT1 |
Fc epsilon RI signaling pathway | IL4;LYN;IL5;FYN;TNF;MAPK3;PLA2G4D;AKT2;MAP2K4 |
Asthma | H2-AB1;HLA-DRB5;HLA-DQA2;RNASE3;FCER1A;CCL11;IL9;IL10;HLA-DQB1 |
FCER1A has several biochemical functions, for example, IgE binding, IgE receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FCER1A itself. We selected most functions FCER1A had, and list some proteins which have the same functions with FCER1A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
IgE binding | FCER1G;Fcer2a;FCER2;CD247L;MS4A2;FCER1A;LGALS3 |
IgE receptor activity | MS4A2;FCER1G;CD247L;FCER1A |
FCER1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCER1A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCER1A.
PDHB
- Q&As
- Reviews
Q&As (6)
Ask a questionModulation of FCER1A expression can be achieved through techniques such as gene knockout, gene silencing, or gene transduction. In addition, its expression levels can also be affected by altering environmental factors such as nutrition, inflammation, etc.
The expression level of FCER1A can be detected by gene expression profiling or immunohistochemistry.
FCER1A plays a key role in the immune system, recognizing and presenting antigens to T cell receptors, thereby initiating an adaptive immune response.
Studies have shown that FCER1A is associated with the risk of some autoimmune diseases, inflammatory diseases, and certain cancers.
Studying FCER1A can help to gain insight into the mechanisms of immune response and inflammatory response, which is of great significance for the development of new drugs and therapeutic strategies. In addition, it is also of great value for understanding the pathogenesis and prevention of diseases.
FCER1A has complex associations with other genes and proteins, such as its interaction with T cell receptors, inflammatory factors, etc.
Customer Reviews (3)
Write a reviewFCER1A can maintain its biological activity and structural integrity under specific experimental conditions.
FCER1A quality is stable and reliable, with no significant differences between batches.
FCER1A has high chemical and physical stability and is suitable for long-term storage and use.
Ask a Question for All FCER1A Products
Required fields are marked with *
My Review for All FCER1A Products
Required fields are marked with *