FCRL2

Official Full Name

Fc receptor-like 2

Background

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Synonyms

FCRL2; Fc receptor-like 2; SH2 domain containing phosphatase anchor protein 1 , SPAP1; Fc receptor-like protein 2; CD307b; FCRH2; IRTA4; fcR-like protein 2; IFGP family protein 4; fc receptor homolog 2; immunoglobulin superfamily Fc receptor, gp42; SH2 domain containing phosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein 1; immune receptor translocation-associated protein 4; immunoglobulin receptor translocation-associated protein 4; IFGP4; SPAP1; SPAP1A; SPAP1B; SPAP1C