Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

FECH

  • Official Full Name

    ferrochelatase

  • Overview

    The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous;form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with;erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A;pseudogene of this gene is found on chromosome 3.
  • Synonyms

    FECH; ferrochelatase; ferrochelatase (protoporphyria); ferrochelatase, mitochondrial; protoporphyria; EPP; FCE; Ferrochelatase mitochondrial; Heme synthetase; Protoheme ferro lyase; heme synthase; protoheme ferro-lyase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FECH-1138H Recombinant Human FECH Mammalian Cell His
Human FECH-12837H Recombinant Human FECH, His-tagged E.coli His 60-423a.a.
Human FECH-6267HCL Recombinant Human FECH 293 Cell Lysate HEK293 N/A
Human FECH-4065H Recombinant Human FECH Protein, GST-tagged Wheat Germ GST
Human FECH-4778HF Recombinant Full Length Human FECH Protein, GST-tagged In Vitro Cell Free System GST 423 amino acids
Human FECH-1007H Recombinant Human FECH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FECH-1762HFL Recombinant Full Length Human FECH Protein, C-Flag-tagged Mammalian cells Flag
Human FECH-2604H Recombinant Human FECH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FECH-2316H Recombinant Human FECH Protein (Gly55-Gln422), N-His tagged E.coli N-His Gly55-Gln422
Human FECH-01H Recombinant human FECH protein, C-Myc/DDK-tagged HEK293T C-Myc/DDK
Human FECH-905H Recombinant Human FECH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FECH-905H-B Recombinant Human FECH Protein Pre-coupled Magnetic Beads HEK293
Mouse Fech-2984M Recombinant Mouse Fech Protein, Myc/DDK-tagged HEK293T Myc/DDK
Bovine FECH-2899B Recombinant Bovine FECH protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 48-416aa
Zebrafish FECH-9169Z Recombinant Zebrafish FECH Mammalian Cell His
Chicken FECH-5770C Recombinant Chicken FECH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FECH Related Articles
  • FECH Related Research Area

FECH involved in several pathways and played different roles in them. We selected most pathways FECH participated on our site, such as Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FECH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Porphyrin and chlorophyll metabolismGUSB;UGT1A6B;UGT1A9;ALAS2;UGT2A3;P22;UROS;HMBSA;UGT2B15
Metabolic pathwaysPDHX;ALDH9A1B;PNLIPRP2;RDH8;CYP2C54;QDPRA;PPAP2D;GLULB;GNSA

FECH has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, ferrochelatase activity, ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FECH itself. We selected most functions FECH had, and list some proteins which have the same functions with FECH. You can find most of the proteins on our site.

Function Related Protein
2 iron, 2 sulfur cluster bindingAOX3L1;CIAPIN1;FDX1L;AIFM3;CISD3;ISCUB;SDHB;CISD2;UQCRFS1
ferrochelatase activity
ferrous iron bindingCDO1;FTO;ACP5;BCO1;NT5E;TRR1;TH;TET2;FECH
heme bindingCBSB;CYP8B1;CYP4T8;HBA1;NOS2;CBS;CYP2D26;FAM84B;PTGS1
iron-responsive element bindingIREB2;FECH;ACO1
protein bindingMAX;ITGB1BP2;BTBD1;ACACB;C5orf20;FOXO3;ST8SIA5;PLCE1;BCL6

FECH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FECH here. Most of them are supplied by our site. Hope this information will be useful for your research of FECH.

Ppp2r1a; USP42; USP20; ATM; gag-pol; MME; Alas2; Fech; PPP2R1A; Cpox; Slc25a4; Ppox; Slc25a5; PPP2CB; PPP2CA; CLPP; Vdac2; Abcb7

Afshar-Oromieh, A; Avtzi, E; et al. The diagnostic value of PET/CT imaging with the Ga-68-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 42:197-209(2015).
Barman-Aksozen, J; Minder, EI; et al. In ferrochelatase-deficient protoporphyria patients, ALAS2 expression is enhanced and erythrocytic protoporphyrin concentration correlates with iron availability. BLOOD CELLS MOLECULES AND DISEASES 54:71-77(2015).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All FECH Products

Required fields are marked with *

My Review for All FECH Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends