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FERMT3

Official Full Name

FERMT3 fermitin family member 3 [ Homo sapiens ]
Overview

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms

fermitin family member 3; 23151; Ensembl:ENSG00000149781; MGC10966; fermitin family homolog 3; kindlin 3; MIG2-like protein; UNC-112 related protein 2; unc-112-related protein 2; URP2; KIND3; MIG-2; MIG2B; URP2SF; UNC112C;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FERMT3-12846H	Recombinant Human FERMT3, His-tagged	E.coli	His	321-663a.a.	$319 / 25ug
Human	FERMT3-6261HCL	Recombinant Human FERMT3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FERMT3-4787HF	Recombinant Full Length Human FERMT3 Protein, GST-tagged	In Vitro Cell Free System	GST	663 amino acids	Inquiry
Human	FERMT3-4077H	Recombinant Human FERMT3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FERMT3-1223H	Recombinant Human FERMT3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FERMT3 Related Articles

FERMT3 involved in several pathways and played different roles in them. We selected most pathways FERMT3 participated on our site, such as Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FERMT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Platelet activation	PPP1CB;NOS3;PLA2G4D;PLCB4;LCP2;APBB1IP;PRKACB;ARHGEF12;GNAQ

FERMT3 has several biochemical functions, for example, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FERMT3 itself. We selected most functions FERMT3 had, and list some proteins which have the same functions with FERMT3. You can find most of the proteins on our site.

Function	Related Protein
integrin binding	TGFBI;TLN1;CYR61L1;DST;ICAM1;KDR;NOV;PXN;GPNMB

FERMT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FERMT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FERMT3.

VCAM1; LSM8; EXOSC10; ugpC; TINF2; UHRF1BP1L; ZC3H18; h0y2u5_human; EIF4E2; PDCD6; SNRNP200; MYC; FN1; COX5A; PRDX5; STXBP1; PRDX1

Huet-Calderwood, C; Brahme, NN; et al. Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation. JOURNAL OF CELL SCIENCE 127:4308-4321(2014).

Suratannon, N; Chatchatee, P; et al. Adaptive Immune defect in a rare phagocytic disorder: leukocyte adhesion deficiency III with a novel missense mutation in FERMT3. ALLERGY 69:500-500(2014).