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FFAR1

  • Official Full Name

    free fatty acid receptor 1

  • Overview

    This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.
  • Synonyms

    FFAR1; free fatty acid receptor 1; G protein coupled receptor 40 , GPR40; FFA1R; FFAR 1; G protein coupled receptor 40; GPR 40; G protein-coupled receptor 40; G-protein coupled receptor 40; GPR40; GPCR40;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mesocricetus auratus (Golden hamster)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FFAR1-8754H Active Recombinant Human FFAR1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human FFAR1-12852H Recombinant Human FFAR1, GST-tagged E.coli GST C-term-60a.a.
Human FFAR1-6257HCL Recombinant Human FFAR1 293 Cell Lysate HEK293 N/A
Human FFAR1-1040HFL Recombinant Human FFAR1 protein, His&Flag-tagged HEK293 His&Flag 1-300 aa
Mouse FFAR1-5827M Recombinant Mouse FFAR1 Protein Mammalian Cell His
Mouse FFAR1-3217M Recombinant Mouse FFAR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FFAR1-3217M-B Recombinant Mouse FFAR1 Protein Pre-coupled Magnetic Beads HEK293
Rat FFAR1-2318R Recombinant Rat FFAR1 Protein Mammalian Cell His
Rat FFAR1-1975R-B Recombinant Rat FFAR1 Protein Pre-coupled Magnetic Beads HEK293
Rat FFAR1-1975R Recombinant Rat FFAR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL2299HF Recombinant Full Length Human Free Fatty Acid Receptor 1(Ffar1) Protein, His-Tagged E.coli expression system His Full Length (1-300)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL6650MF Recombinant Full Length Macaca Fascicularis Free Fatty Acid Receptor 1(Ffar1) Protein, His-Tagged E.coli expression system His Full Length (1-300)
Mesocricetus auratus (Golden hamster) RFL29344MF Recombinant Full Length Mesocricetus Auratus Free Fatty Acid Receptor 1(Ffar1) Protein, His-Tagged E.coli expression system His Full Length (1-300)
Mus musculus (Mouse) RFL9613MF Recombinant Full Length Mouse Free Fatty Acid Receptor 1(Ffar1) Protein, His-Tagged E.coli expression system His Full Length (1-300)
Rattus norvegicus (Rat) RFL23697RF Recombinant Full Length Rat Free Fatty Acid Receptor 1(Ffar1) Protein, His-Tagged E.coli expression system His Full Length (1-300)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FFAR1 Related Articles
  • FFAR1 Related Research Area

FFAR1 involved in several pathways and played different roles in them. We selected most pathways FFAR1 participated on our site, such as Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with FFAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Insulin secretionGLP1R;CAMK2D;GIP;INS1;KCNMB4;GPR119;RIMS2;SNAP25;PRKCA

FFAR1 has several biochemical functions, for example, G-protein coupled receptor activity, bioactive lipid receptor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FFAR1 itself. We selected most functions FFAR1 had, and list some proteins which have the same functions with FFAR1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityMRGPRB8;SETD6;OR2H1;HCAR1-2;CHRM5A;OLFR494;OLFCG5;OPNP;OPN4A
bioactive lipid receptor activity
guanyl-nucleotide exchange factor activityFGD6;DOCK5;P2RY12;RASGRP1;SERGEF;DENND6A;RAPGEF6;DENND1C;DENND4B
lipid bindingAPOL6;SEC14L3;CHMP4A;APOL3;FABP11A;EPN1;FABP12;SH3GLB1;PACSIN1B

FFAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FFAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FFAR1.

Teutsch, CA; Panse, M; et al. Detection of free fatty acid receptor 1 expression: the critical role of negative and positive controls. DIABETOLOGIA 57:776-780(2014).
Nagatake, T; Fujita, H; et al. Enteroendocrine Cells Are Specifically Marked by Cell Surface Expression of Claudin-4 in Mouse Small Intestine. PLOS ONE 9:-(2014).
Hirasawa, A; Itsubo, C; et al. Production and characterization of a monoclonal antibody, against GPR40 (FFAR1; free fatty acid receptor 1). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 365:22-28(2008).
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