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FGF8

  • Official Full Name

    fibroblast growth factor 8 (androgen-induced)

  • Overview

    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.
  • Synonyms

    FGF8; fibroblast growth factor 8 (androgen-induced); fibroblast growth factor 8; AIGF; androgen-induced growth factor; heparin-binding growth factor 8; KAL6; FGF-8; HBGF-8; MGC149376;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Chicken
  • Horse
  • Human
  • Human/Mouse
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • Human cells
  • Mammalian Cell
  • C
  • His
  • Fc
  • His(C
  • ter)
  • GST
  • SUMO
  • Met
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGF8-771H Active Recombinant Human FGF8 Protein E.coli N/A
Human FGF8-348H Active Recombinant Human FGF8, Met-tagged E.coli Met
Human FGF8-374H Active Recombinant Human Fibroblast Growth Factor 8 (Androgen-induced) HEK293 N/A
Human FGF8-01H Active Recombinant Human FGF8 Protein, His-Tagged HEK293 His 204aa
Human FGF8-789H Recombinant Human FGF8 Protein, His-tagged E.coli His
Human FGF8-28885TH Recombinant Human FGF8 E.coli N/A
Human FGF8-6234HCL Recombinant Human FGF8 293 Cell Lysate HEK293 N/A
Human FGF8-1500H Recombinant Human FGF8 Protein, His-tagged E.coli N-His Gln23-Arg233
Human FGF8-647H Active Recombinant Human FGF8 Protein (Gln23-Arg215), Met E.coli N/A Gln23-Arg215
Human FGF8-3362H Recombinant Human FGF8 protein, His-SUMO-tagged E.coli His-SUMO Gln52~Glu204
Human FGF8-1418H Recombinant Human FGF8 protein, His-GST-tagged E.coli His/GST 23-143aa
Human FGF8-12H Active Recombinant Human FGF8 Protein, Animal Free Human cells
Human FGF8-047HG Active GMP Recombinant Human FGF8 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human FGF-8b(NP_149355.1) was expressed with Fc tag at the C-terminal.
Human FGF8-2916H Recombinant Human FGF8 Protein (Gln23-Arg233), N-His tagged E.coli N-His Gln23-Arg233
Human FGF8-90H Recombinant Active Human FGF8 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human FGF8-411F Active Recombinant Human FGF8 Protein (194 aa) E.coli 194
Human FGF8-3363H Recombinant Human FGF8 protein, His-tagged E.coli His Gln52~Glu204
Human FGF8-2918H Recombinant Human FGF8 Protein (Gln23-Arg215) E.coli Tag Free Gln23-Arg215
Human FGF8-99H Active Recombinant Human FGF8 Protein (Gln52-Arg223), C-His tagged, Animal-free, Carrier-free E.coli C-His Gln52-Arg223
Human FGF8-041H Active Recombinant Human FGF8 Protein E. coli
Human FGF8-2915H Recombinant Human FGF8 Protein (Gln23-Arg204), N-His tagged E.coli N-His Gln23-Arg204
Human FGF8-2917H Recombinant Human FGF8 Protein (Gln23-Arg244), N-His tagged E.coli N-His Gln23-Arg244
Human FGF8-100H Active Recombinant Human FGF8 Protein (Gln52-Arg223), C-His tagged, Animal-free, Carrier-free E.coli C-His Gln52-Arg223
Mouse Fgf8-539M Recombinant Mouse Fgf8 protein E.coli N/A 246
Horse FGF8-934H Recombinant Horse FGF8 Protein, His-tagged E.coli N-His Arg44-Thr229
Horse FGF8-3321H Recombinant Horse FGF8 protein, His-tagged E.coli His Gln23~Arg244
Human/Mouse FGF8-93H Active Recombinant Human/Mouse FGF8 Protein E.coli
Human/Mouse FGF8-91H Active Recombinant Human/Mouse FGF8 Protein E.coli
Human/Mouse FGF8-92H Active Recombinant Human/Mouse FGF8 Protein E.coli
Chicken FGF8-1997C Recombinant Chicken FGF8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FGF8 Related Articles
  • FGF8 Related Signal Pathway

FGF8 involved in several pathways and played different roles in them. We selected most pathways FGF8 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayNFKB1;FOS;MAP3K1;AKT2L;TMEM37;MAP2K6;TGFBR2;TRAF6;RASA2
Ras signaling pathwayRALB;REL;FGF1;PIK3R5;FGFR4;GNG11;GNG8;KITLG;PDGFA
Rap signaling pathwayMAPK13;PDGFRA;MAP2K6;FGF9;ITGB2;PLCE1;PRKD2;ITGAM;Pdgfa&Pdgfb
PIK-Akt signaling pathwayMTCP1;RPS6KB2;IL7R;GNB4;LAMC1;MLST8;IL2RB;TNR;COL6A6
Regulation of actin cytoskeletonARHGEF4;PIK3R5;ITGB6;INS;FGF11A;ITGA7;PPP1R12B;PTK2;WASB
Pathways in cancerIL-8;BMP4;CTNNA3;RARB;GNAI3;FGF16;FGF1;SMO;GNG10
MelanomaMAPK1;CCND1;FGF19;FGF21;PDGFB;PDGFD;PDGFRB;FGF11;MAPK3

FGF8 has several biochemical functions, for example, chemoattractant activity, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF8 itself. We selected most functions FGF8 had, and list some proteins which have the same functions with FGF8. You can find most of the proteins on our site.

Function Related Protein
chemoattractant activityVEGFC;HMGB1;FGF10;FGF2;FIGF;SAA4;PDGFB;CCL15;CCL5
fibroblast growth factor receptor bindingFGF22;FGF9;FGF6A;FRS2;FGF3;FGF21;FGF1;FGF10B;FGF6
growth factor activityFGF1;PGF;PROK1;MIA1;SPAW;CSF2;MIA;EREG;F2
type 1 fibroblast growth factor receptor bindingFGF17;FGF18;NPTN;FGF8
type 2 fibroblast growth factor receptor bindingFGF8;FGF17;FGF7;FGF10;FGF18

FGF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF8.

FGFR1; FGFR2

Sautter, NB; Delaney, KL; et al. Tissue remodeling gene expression in a murine model of chronic rhinosinusitis. LARYNGOSCOPE 122:711-717(2012).
Sato, A; Scholl, AM; et al. FGF8 signaling is chemotactic for cardiac neural crest cells. DEVELOPMENTAL BIOLOGY 354:18-30(2011).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does FGF8 participate in embryonic development, particularly in the patterning of the midbrain and limb buds, and what molecular events coordinate its spatial and temporal expression? 06/03/2021

FGF8 is essential for midbrain and limb bud patterning during embryonic development. Spatial and temporal expression is coordinated by signaling pathways and transcription factors that regulate FGF8 expression.

How do post-translational modifications, such as glycosylation, impact the function of FGF8, and what is the significance of these modifications in modulating ligand-receptor interactions? 09/14/2020

Post-translational modifications, including glycosylation, can influence FGF8 function. Glycosylation may modulate ligand-receptor interactions, affecting the specificity and strength of FGF8 signaling.

What is the structural classification of FGF8, and how does its tertiary structure influence interactions with FGF receptors and heparin sulfate proteoglycans? 08/27/2019

FGF8 is a member of the fibroblast growth factor family with a β-trefoil tertiary structure. This structure dictates its binding to FGF receptors and heparin sulfate proteoglycans, essential for signal transduction.

How does FGF8 participate in the crosstalk between different signaling pathways, such as Wnt and Shh, and what are the consequences for tissue morphogenesis and organogenesis? 03/18/2019

FGF8 engages in crosstalk with pathways like Wnt and Shh during tissue morphogenesis. This interaction influences organogenesis by coordinating cellular processes and ensuring proper tissue patterning.

Can you discuss the interactions between FGF8 and the extracellular matrix, and how these interactions influence the stability and bioavailability of FGF8 ligands in the tissue microenvironment? 02/05/2018

FGF8 interacts with the extracellular matrix, affecting ligand stability and bioavailability. This interaction modulates FGF8 diffusion and gradients in the tissue microenvironment.

Customer Reviews (3)

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Reviews
07/08/2021

    Top-quality and timely delivery. It's a pleasure working with this product.

    06/30/2020

      Service, quality, and shipping—all exceptional. This product is our research ally.

      10/09/2019

        Seamless shipping and a product that never disappoints. Kudos!

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