Fgfr3
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Official Full Name
fibroblast growth factor receptor 3
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Overview
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009] -
Synonyms
FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Chicken
- Cynomolgus
- Cynomolgus Monkey
- Gallus gallus (Chicken)
- Human
- Human
- Monkey
- Mouse
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293E
- HEK293T
- Human
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- DDK
- DDK|His
- Fc
- Fc Chimera
- FC
- Fc|His
- His(C
- ter)
- Flag
- GST
- hFc
- his
- His (Fc)
- Avi
- His|Fc
- His|HIgG
- His|T7
- B2M
- Myc
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Fgfr3 Related Articles
- Fgfr3 Related Gene Family
- Fgfr3 Related Research Area
- Fgfr3 Related Signal Pathway
Fgfr3 involved in several pathways and played different roles in them. We selected most pathways Fgfr3 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgfr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | HSPA6;IL1R2;GNA12;BRAF;RELA;CACNG4;PRKACBA;FOS;RPS6KA3B |
Ras signaling pathway | PLA2G4C;GNG7;PAK7;FLT4;GNB1;GNG2;PLA2G2E;ZAP70;GNG5 |
Rap signaling pathway | CALM3;PRKCG;GRIN2A;PIK3CG;IGF1R;SIPA1L1;PDGFA;PRKCZ;CALML3 |
Endocytosis | VPS36;HSP70;CHMP4C;ARPC1B;BIN1B;FOLR3;CLTCB;ARPC5A;MHC1UXA2 |
PIK-Akt signaling pathway | GH2;YWHAE;RPTOR;ITGB5;ITGA1;GNG8;SOS1;ANGPT2;CREB5 |
Signaling pathways regulating pluripotency of stem cells | MEIS1;SKIL;IL6ST;ACVR2A;INHBE;WNT11;KLF4;AXIN2;MAPK1 |
Regulation of actin cytoskeleton | PDGFAA;PXN;MYL1;PIK3R3A;GSN;BDKRB1;PAK2B;PIP5K1BA;ITGAV |
Pathways in cancer | F2R;GNB3;MSH2;ROCK1;CYCS;WNT2B;FH;ZBTB16;FGFR3 |
MicroRNAs in cancer | UBE2I;HRAS;FOXP1;SHC4;ABCB1A;IRS2;MCL1;PLCG2;MAPK7 |
Bladder cancer | RAF1;UPK3A;TP53;IL-8;MMP1A;HBEGF;MDM2;MMP2;MAPK3 |
Central carbon metabolism in cancer | AKT2;AKT1;PDGFRB;PDHB;SCO2;PIK3CA;HK2;MAP2K2;SLC1A5 |
Fgfr3 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgfr3 itself. We selected most functions Fgfr3 had, and list some proteins which have the same functions with Fgfr3. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | TBCK;PRKCB;SMARCA2;MAP2K5;GSS;ATPBD4;HK3;CDC42BPB;MAPK12 |
fibroblast growth factor binding | RPS2;TGFBR3;FGFRL1;FGFBP1;FGFR2;CEP57;FIBPA;SCN5A;FGFR1A |
fibroblast growth factor-activated receptor activity | FGFR1A;FGFR4;FGFRL1;FGFR1;FGFR3;FGFR2;FGFR1B |
protein binding | LDB3;LGALS6;RAB7;FBXO18;AZIN1;BMP1A;FAM131B;MAP2K6;AGO2 |
protein tyrosine kinase activity | NTRK2B;FES;JAK2A;TYK2;EPHA4B;EPHB4A;CSK;MAP2K4;INSRA |
Fgfr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgfr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgfr3.
FGF1; HSP90AB1; saicar; PKM; CTGF; abl-tide; HSPG2; CDC37; NDUFS6; HBZ; CHGB; KRT8; SLC25A6; HNRNPL; ATF3; CTSK
- Q&As
- Reviews
Q&As (5)
Ask a questionFGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.
FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.
Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.
Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.
FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.
Customer Reviews (3)
Write a reviewResearchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.
Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.
Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.
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