FGG
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Official Full Name
fibrinogen gamma chain
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Overview
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three;pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin;which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin;regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several;cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and;thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
FGG; fibrinogen gamma chain; fibrinogen, gamma polypeptide;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Sheep
- Zebrafish
- Bovine Plasma
- Dog Plasma
- E.coli
- HEK293
- HEK293T
- Human plasma
- In Vitro Cell Free System
- Mammalian Cell
- Porcine plasma
- Rabbit Plasma
- Rat plasma
- Sheep Plasma
- Wheat Germ
- Yeast
- C
- Myc
- DDK
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FGG Related Articles
- FGG Related Research Area
FGG involved in several pathways and played different roles in them. We selected most pathways FGG participated on our site, such as Complement and coagulation cascades, Platelet activation, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C1QC;LOC100514666;F8;PLAUR;PROS1;F2R;PROC;CPB2;PLG |
| Platelet activation | MYLK3;AKT2;MYLK2;PIK3CD;ITGA2B;STIM1;GNAS;PLA2G4D;PLCB4 |
| Staphylococcus aureus infection | MBL2;SELP;FCGR2B;ITGAL;C3AR1;C1RA;FPR1;C1S;HLA-DMA |
FGG has several biochemical functions, for example, cell adhesion molecule binding, metal ion binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by FGG itself. We selected most functions FGG had, and list some proteins which have the same functions with FGG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesion molecule binding | TIGIT;LILRB2;PVRL2L;CADM1B;PVRL2;NRXN1;PVRL1A;CRTAM;VCAM1 |
| metal ion binding | TEC;MICAL2B;ATP1A1A.1;CNDP1;EYA1;ZC3H7A;TRIM67;CHN2;TRIM3B |
| protein binding, bridging | CSTA;CUX1;FBXW7;NUFIP1;FSCN2B;FKBP4;SH2D1B;TIRAP;CBX5 |
| receptor binding | GSDMA2;F2RL1;APLN;SLC39A1;TNFSF4;PARK7;PVRL1A;PEX14;ENSA |
| structural molecule activity | MAP2;SNTG1;ISCA2;CLDN19;KRT18;NEFMB;CLDNE;KRT31;NEFLB |
FGG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGG here. Most of them are supplied by our site. Hope this information will be useful for your research of FGG.
FGA; ICAM1; q9wmx2-pro_0000037550; d-mannose
- Q&As
- Reviews
Q&As (5)
Ask a questionInflammatory stimuli and cytokines can modulate FGG gene expression, influencing the synthesis of fibrinogen gamma chain during inflammatory responses.
The FGG gamma chain, along with alpha and beta chains, contributes to the polymerization of fibrin by forming intermolecular bonds between fibrin molecules.
Fibrinogen is a crucial factor in blood coagulation, as it is converted to fibrin during the final stages of the coagulation cascade, forming a stable blood clot.
Fibrinogen (FGG), converted to fibrin, forms the matrix for blood clotting at wound sites, facilitating tissue repair and providing a scaffold for cell migration.
The FGG gene is transcribed in hepatocytes, and the resulting mRNA is translated into the fibrinogen gamma chain during the synthesis of fibrinogen.
Customer Reviews (3)
Write a reviewThis product consistently delivers accurate results in our experiments.
Ordered, and this product was in our hands sooner than expected, facilitating our research timeline.
Quick service! The team provided efficient assistance in choosing the right protein for us.
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