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FBL

  • Official Full Name

    fibrillarin

  • Overview

    This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
  • Synonyms

    FBL; fibrillarin; rRNA 2-O-methyltransferase fibrillarin; FIB; FLRN; RNU3IP1; 34-kD nucleolar scleroderma antigen; 34 kDa nucleolar scleroderma antigen; RNA, U3 small nucleolar interacting protein 1; CG9888 gene product from transcript CG9888-RA; 34 kD nucleolar scleroderma antigen; FBRL_HUMAN; FIB1; Nop1p; rRNA 2 O methyltransferase fibrillarin; CG9888-PA; Fib-PA; CG9888; Dmel\CG9888; Fibri; GCR-6; GCR6; pen59C5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBL-791H Recombinant Human Fibrillarin, His-tagged E.coli His
Human FBL-3869H Recombinant Human FBL Protein, GST-tagged Wheat Germ GST
Human FBL-12762H Recombinant Human FBL, His-tagged E.coli His 1-321a.a.
Human FBL-84H Recombinant Human Fibrillarin Protein, His-tagged E. coli His 1-321
Human FBL-83H Recombinant Human Fibrillarin Protein, GST-tagged E.coli GST 1-321
Human FBL-89H Recombinant Human FBL Protein, GST-tagged E.coli GST 2-78
Human FBL-85H Recombinant Human FBL Protein, His-tagged E.coli His Gly37~Ala275
Human FBL-6319HCL Recombinant Human FBL 293 Cell Lysate HEK293 N/A
Human FBL-4877HF Recombinant Full Length Human FBL Protein, GST-tagged In Vitro Cell Free System GST 321 amino acids
Human FBL-892H Recombinant Human FBL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FBL-112HFL Recombinant Full Length Human FBL Protein, C-Flag-tagged Mammalian cells Flag
Human FBL-2503H Recombinant Human FBL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FBL-892H-B Recombinant Human FBL Protein Pre-coupled Magnetic Beads HEK293
Mouse FBL-5698M Recombinant Mouse FBL Protein Mammalian Cell His
Mouse FBL-3130M Recombinant Mouse FBL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FBL-3130M-B Recombinant Mouse FBL Protein Pre-coupled Magnetic Beads HEK293
Mouse Fbl-1022M Recombinant Mouse Fbl Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat FBL-2281R Recombinant Rat FBL Protein Mammalian Cell His
Rat Fbl-7817R Recombinant Rat Fbl protein, His & T7-tagged E.coli His/T7 Gly85~Cys274 (Accession # P22509)
Rat FBL-1938R-B Recombinant Rat FBL Protein Pre-coupled Magnetic Beads HEK293
Rat FBL-1938R Recombinant Rat FBL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FBL-12246Z Recombinant Zebrafish FBL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FBL Related Articles

FBL involved in several pathways and played different roles in them. We selected most pathways FBL participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ribosome biogenesis in eukaryotesPWP2H;SMFN;GNL2;LOC81691;XPO1;POP5;MPHOSPH10;NOP58;WDR3

FBL has several biochemical functions, for example, ATPase binding, RNA binding, TFIID-class transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBL itself. We selected most functions FBL had, and list some proteins which have the same functions with FBL. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingPTPN3;LCK;ATP1B3;PEX19;FBL;FXYD7;NUFIP1;BBC3;ATP1B2
RNA bindingHNRNPM;BARD1;FUS;PCBP2;TRNAU1APA;DDX3Y;ATXN2;SFPI1;DIMT1
TFIID-class transcription factor bindingFBL;ERCC4;ERCC1;NOP58;ZNHIT6
histone-glutamine methyltransferase activity
poly(A) RNA bindingCORO1A;RRP7A;EIF2S1;TUFM;AKAP8L;NUCKS1;MTIF2;HNRNPA2B1;EEF2
protein bindingPPP2R2C;MED6;AES;TFF1;GATA2;FAM193B;CEBPA;RAD9B;PBXIP1
rRNA methyltransferase activityFAM86;DIMT1;TRMT10B;PRDM11;PRMT8B;PRDM12;NDUFAF5;METTL8;METTL23

FBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBL here. Most of them are supplied by our site. Hope this information will be useful for your research of FBL.

SMN1; ARRB2; DDX5; LOC100911617; Prmt3; Prmt1; Prmt1; RTCA; RIOK3; CFLAR; CIAO1

Shih, TS; Her, I; et al. EMULATING THE HUMAN TIBIOFEMORAL JOINT BY USING A FOUR-BAR LINKAGE, CONDYLAR SHAPES AND SLIP RATIO VARIATION. INTERNATIONAL JOURNAL OF ROBOTICS & AUTOMATION 30:70-78(2015).
Hisamoto, N; Li, C; et al. The C-elegans HGF/Plasminogen-like Protein SVH-1 Has Protease-Dependent and -Independent Functions. CELL REPORTS 9:1628-1634(2014).
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