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FIP1L1

Official Full Name

FIP1 like 1 (S. cerevisiae)
Overview

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3 end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms

FIP1L1; FIP1 like 1 (S. cerevisiae); pre-mRNA 3-end-processing factor FIP1; DKFZp586K0717; Factor interacting with PAP; FIP1; FIP1 like 1 (S cerevisiae); FIP1 like 1; FLJ33619; hFip 1; hFip1; Pre mRNA 3 end processing factor FIP1; Rearranged in hypereosinophilia; RHE; FIP1-like 1 protein;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FIP1L1-276HCL	Recombinant Human FIP1L1 lysate	HEK293	N/A		Inquiry
Human	FIP1L1-5113HF	Recombinant Full Length Human FIP1L1 Protein, GST-tagged	In Vitro Cell Free System	GST	378 amino acids	Inquiry
Human	FIP1L1-0307H	Recombinant Human FIP1L1 Protein (S2-E594), Tag Free	Insect Cell	No tag	S2-E594	Inquiry
Human	FIP1L1-4177H	Recombinant Human FIP1L1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FIP1L1-0308H	Recombinant Human FIP1L1 Protein (S2-E594), His/GST tagged	Insect Cell	His/GST	S2-E594	Inquiry
Mouse	FIP1L1-5894M	Recombinant Mouse FIP1L1 Protein	Mammalian Cell	His		Inquiry
Mouse	FIP1L1-3261M-B	Recombinant Mouse FIP1L1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	FIP1L1-3261M	Recombinant Mouse FIP1L1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FIP1L1 Related Articles

FIP1L1 involved in several pathways and played different roles in them. We selected most pathways FIP1L1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FIP1L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
mRNA surveillance pathway	PCF11;PABPC3;PPP2R3C;MAGOHB;NXF2;PPP2CA;ETF1;MSI2A;ETF1B

FIP1L1 has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FIP1L1 itself. We selected most functions FIP1L1 had, and list some proteins which have the same functions with FIP1L1. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	EIF2S1B;ZCCHC8;IFI16;SLIRP;HIST1H4D;DMGDH;CPNE3;SYNE1;FMR1
protein binding	URI1;GSG2;DVL2;CRTAC1;ROPN1L;GHRL;CXCL9;COG1;TXK

FIP1L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FIP1L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FIP1L1.

NAA10; GOLGA2; ZMYND19; CPSF4; FOS; GSK3B; WWOX; PRMT2; tdh; TFAP2C; PRMT6; ssrna_ug

Zeng, K; Li, L; et al. Newly identified phenotypes in a FIP1L1/PDGFRA-associated paediatric HES patient: thrombocytosis, mHPA, young stroke and blindness. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 29:614-616(2015).

Chalmers, ZR; Ali, SM; et al. Comprehensive genomic profiling identifies a novel TNKS2-PDGFRA fusion that defines a myeloid neoplasm with eosinophilia that responded dramatically to imatinib therapy. BLOOD CANCER JOURNAL 5:-(2015).