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FLNA

  • Official Full Name

    filamin A, alpha

  • Overview

    The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    FLNA; filamin A, alpha; filamin A, alpha (actin binding protein 280) , FLN, FLN1, OPD1, OPD2; filamin-A; ABP 280; actin binding protein 280; filamin-1; alpha-filamin; non-muscle filamin; endothelial actin-binding protein; FLN; FMD; MNS; OPD; ABPX; CVD1; F;

  • Recombinant Proteins
  • Native Proteins
  • Chicken
  • Human
  • Mouse
  • Turkey
  • Chicken Gizzard
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Turkey gizzard muscle
  • Wheat Germ
  • Flag
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FLNA-28906TH Recombinant Human FLNA, His-tagged E.coli His
Human FLNA-289H Recombinant Human FLNA, GST-tagged Wheat Germ GST
Human FLNA-185H Recombinant Human FLNA protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FLNA-413H Recombinant Human FLNA Protein, His-tagged E.coli His Ser2~Pro274
Human FLNA-5086H Recombinant Human FLNA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FLNA-2923H Recombinant Human FLNA protein, His&Myc-tagged E.coli His&Myc 2-274aa
Human FLNA-4155HFL Recombinant Full Length Human FLNA protein, Flag-tagged Mamanlian cells Flag
Mouse Flna-3038M Recombinant Mouse Flna Protein, Myc/DDK-tagged HEK293T Myc/DDK
Turkey FLNA-873T Native Turkey FLNA Protein Turkey gizzard muscle N/A
Chicken FLNA-170C Active Native chicken FLNA Chicken Gizzard N/A
Chicken FLNA-6143C Recombinant Chicken FLNA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FLNA Related Articles

FLNA involved in several pathways and played different roles in them. We selected most pathways FLNA participated on our site, such as MAPK signaling pathway, Focal adhesion, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFASLG;NLK1;FGF1B;NFATC1;MAPK12;MAP2K3;BRAF;FGF8;CACNA1C
Focal adhesionMAPK9;RAP1AB;PAK2A;AKT3A;XIAP;COL4A6;ITGB5;VASP;MYL9A
Salmonella infectionIL8L2;RILP;ROCK2A;NOS2A;RHOGC;FOS;RAC1A;ACTB1;DYNC1I1
Proteoglycans in cancerITPR1;PRKACB;RPS6;FZD6;TGFB2;GPC3;ARHGEF1;ITGA5;TGFB1

FLNA has several biochemical functions, for example, Fc-gamma receptor I complex binding, Rac GTPase binding, Ral GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLNA itself. We selected most functions FLNA had, and list some proteins which have the same functions with FLNA. You can find most of the proteins on our site.

Function Related Protein
Fc-gamma receptor I complex bindingFGR;FLNA
Rac GTPase bindingITPKA;PAK2B;FLNA;NOXA1;CORO1C;CDKL5;ARHGEF2;SOD1;DOCK4
Ral GTPase bindingEXOC5;USP33;PRKCH;MYO1C;RNF41;LSM2;RALBP1;EXOC8;RAB34
Rho GTPase bindingDAAM1;DIAP3;CSDA;DIAPH3;INF2;IQGAP3;PFN1;KIF3B;PARD6A
SMAD bindingSKIL;USP15;SKOR1B;RNF111;HMGA2;BMPR1B;STUB1;SMAD2;AXIN1
actin filament bindingVIL1;SHROOM1;CORO1B;ADD1;HIST1H2AH;FSCN2A;MYH9A;ABL2;MTSS1
glycoprotein bindingSERPINA1;APOH;EDEM2;SHB;STX1A;Shh;SELP;ITGA3;BBC3
mu-type opioid receptor bindingGNAO1B;GNAO1A;GNAS;WLS;FLNA;GNAO1;GPR177
poly(A) RNA bindingTFAM;DIEXF;DIMT1;RPL27A;HSP90AB1;DDX55;RPS27.1;SRP14;RPL13
protein bindingIPO13;CIT;CALM3;EXOC3;NKG7;CRX;Fzd4;LYRM2;TRIM25
protein homodimerization activityMID2;ABP1;FLT3LG;TBX15;LHPP;TRIM5;HNF1B;CITED1;TERF2
protein kinase C bindingHDAC7A;ADD3;NELL2;PKN1;MARCKS;TOP2B;C1QBP;ADAM9;TDG
signal transducer activityTAS2R125;CBLC;TAS2R123;ZDHHC17;OLFCG4;LPAR6;MGAA;DRD4B;PROKR1A
small GTPase bindingFGD2;FLNA;PEX5L;TSC2;FGD6;FGD4;PEX5;FGD3;ABCA1
transcription factor bindingPSMC5;PSMD4;APBB1;JUNB;IRF4;HES4;RARA;NAB1;PAX2

FLNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLNA here. Most of them are supplied by our site. Hope this information will be useful for your research of FLNA.

ITGB1; ITGB7; CCNB2

Jacquemet, G; Morgan, MR; et al. Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. JOURNAL OF CELL SCIENCE 126:4121-4135(2013).
Noam, Y; Phan, L; et al. Distinct regional and subcellular localization of the actin-binding protein filamin a in the mature rat brain. JOURNAL OF COMPARATIVE NEUROLOGY 520:3013-3034(2012).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How can FLNA expression levels be measured? 09/02/2022

FLNA expression levels can be detected by gene sequencing, immunohistochemistry, and western blotting.

What might be involved in future research on FLNA? 04/12/2022

Future research on FLNA may involve more in-depth research on molecular mechanisms, new drug development, and targeted therapy strategies based on FLNA. In addition, studies may also address the function and mechanism of action of FLNA in other tissues and organs.

Does FLNA interact with other molecules or drugs? 12/25/2021

There are multiple interactions between FLNA and other molecules and drugs. For example, FLNA can bind to actin, affecting cell migration and morphology. In addition, some drugs can also affect FLNA expression levels or function.

Are there population differences in FLNA treatment? 05/30/2021

It is unclear whether there is a population difference in the treatment of FLNA. However, due to factors such as individual differences and genetic polymorphisms, different populations may respond differently to treatment. Therefore, population-specific treatment strategies may need to be individually adapted and optimized.

What is the treatment of FLNA? 02/12/2021

There is currently no specific treatment for FLNA. However, drugs that target their associated signal transduction pathways or binding targets may have potential therapeutic value.

Can FLNA expression level be used as a biomarker for disease diagnosis or prognosis? 03/23/2020

Current research on FLNA expression levels as a biomarker for disease diagnosis or prognosis is insufficient and further validation is needed.

Customer Reviews (3)

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Reviews
11/28/2021

    The structure is stable and not prone to mutations.

    10/09/2021

      Simplify complex chemical reactions and increase yields and reduce experimental time.

      02/23/2021

        The combination of strong biological activity and high purity results in extremely reliable results.

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