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FMO4

  • Official Full Name

    flavin containing monooxygenase 4

  • Overview

    Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region.Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
  • Synonyms

    FMO4; flavin containing monooxygenase 4; FMO2; dimethylaniline monooxygenase [N-oxide-forming] 4; Dimethylaniline monooxygenase [N oxide forming] 4; Dimethylaniline monooxygenase 4; Dimethylaniline oxidase 4; FMO 2; FMO 4; FMO4_HUMAN; Hepatic flavin containing monooxygenase 4; Hepatic flavin-containing monooxygenase 4; OTTHUMP00000060454;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FMO4-12945H Recombinant Human FMO4, GST-tagged E.coli GST 24-354a.a.
Human FMO4-6182HCL Recombinant Human FMO4 293 Cell Lysate HEK293 N/A
Human FMO4-4393H Recombinant Human FMO4 Protein, GST-tagged Wheat Germ GST
Human FMO4-407H Recombinant Human FMO4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse FMO4-5940M Recombinant Mouse FMO4 Protein Mammalian Cell His
Mouse Fmo4-3055M Recombinant Mouse Fmo4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FMO4-3292M-B Recombinant Mouse FMO4 Protein Pre-coupled Magnetic Beads HEK293
Mouse FMO4-3292M Recombinant Mouse FMO4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FMO4-2369R Recombinant Rat FMO4 Protein Mammalian Cell His
Rat FMO4-2025R Recombinant Rat FMO4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FMO4-2025R-B Recombinant Rat FMO4 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL36786HF Recombinant Full Length Human Dimethylaniline Monooxygenase [N-Oxide-Forming] 4(Fmo4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-558)
Mus musculus (Mouse) RFL11469MF Recombinant Full Length Mouse Dimethylaniline Monooxygenase [N-Oxide-Forming] 4(Fmo4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-560)
Oryctolagus cuniculus (Rabbit) RFL24435OF Recombinant Full Length Rabbit Dimethylaniline Monooxygenase [N-Oxide-Forming] 4(Fmo4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-555)
Rattus norvegicus (Rat) RFL13473RF Recombinant Full Length Rat Dimethylaniline Monooxygenase [N-Oxide-Forming] 4(Fmo4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-560)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FMO4 Related Articles

FMO4 involved in several pathways and played different roles in them. We selected most pathways FMO4 participated on our site, such as Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Drug metabolism - cytochrome PGSTA3;GSTM2;GSTM3;UGT1A4;GSTP1;GSTM7;UGT1A3;UGT2A1;GSTT2B

FMO4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMO4 itself. We selected most functions FMO4 had, and list some proteins which have the same functions with FMO4. You can find most of the proteins on our site.

Function Related Protein
protein bindingINMT;C19orf60;SYT17;SOCS7;FKBPL;LRRC7;ERCC8;LPAR2;STK36

FMO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMO4.

Veeravalli, S; Omar, BA; et al. The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. BIOCHEMICAL PHARMACOLOGY 90:88-95(2014).
Uno, Y; Shimizu, M; et al. Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque. BIOCHEMICAL PHARMACOLOGY 85:1837-1847(2013).
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