FOXA2
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Official Full Name
forkhead box A2
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Overview
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] -
Synonyms
FOXA2; forkhead box A2; HNF3B; TCF3B; hepatocyte nuclear factor 3-beta; HNF-3B; TCF-3B; HNF-3-beta; forkhead box protein A2; transcription factor 3B; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | FOXA2-28944TH | Recombinant Human FOXA2 | E.coli | N/A | ||
Human | FOXA2-127H | Recombinant Human FOXA2 | E.coli | N/A | ||
Human | FOXA2-6163HCL | Recombinant Human FOXA2 293 Cell Lysate | HEK293 | N/A | ||
Human | FOXA2-4433H | Recombinant Human FOXA2 Protein, GST-tagged | Wheat Germ | GST | ||
Human | FOXA2-5046HF | Recombinant Full Length Human FOXA2 Protein, GST-tagged | In Vitro Cell Free System | GST | 457 amino acids | |
Mouse | FOXA2-5976M | Recombinant Mouse FOXA2 Protein | Mammalian Cell | His | ||
Mouse | FOXA2-3314M-B | Recombinant Mouse FOXA2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Foxa2-1510M | Recombinant Mouse Foxa2 Protein, His-tagged | E.coli | N-His | Met1-Ser459 | |
Mouse | FOXA2-3314M | Recombinant Mouse FOXA2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | FOXA2-2383R | Recombinant Rat FOXA2 Protein | Mammalian Cell | His | ||
Rat | FOXA2-2039R-B | Recombinant Rat FOXA2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | FOXA2-2039R | Recombinant Rat FOXA2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | FOXA2-8588Z | Recombinant Zebrafish FOXA2 | Mammalian Cell | His | ||
Chicken | FOXA2-6334C | Recombinant Chicken FOXA2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- FOXA2 Related Articles
- FOXA2 Related Research Area
FOXA2 involved in several pathways and played different roles in them. We selected most pathways FOXA2 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Maturity onset diabetes of the young | FOXA2;NKX6;HES1;PDX1;HNF1A;HNF1B;NEUROG3;INS1;IAPP |
FOXA2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXA2 itself. We selected most functions FOXA2 had, and list some proteins which have the same functions with FOXA2. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | PROX1A;GEN1;SRFA;ZNF530;NR1D4B;TSG101;HIST1H2AN;HIST1H3A;RORAB |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZIC3;JUN;MIXL1;CARF;ZNF460;RFX4;CRX;NFATC4;RELA |
RNA polymerase II transcription factor activity, sequence-specific DNA binding | HIF1AL;ETS1;RUNX2;PLAGL1;OVOL3;LMO2;SOX8;ZSCAN18;SIM1B |
protein domain specific binding | HIST4H4;DBNL;IL1B;CENPJ;TJP1;CALM2;CHMP1A;ZBTB16;RAP2B |
transcription factor activity, sequence-specific DNA binding | RELB;ZIM3;CEBPD;MYCA;MYC;NKX6-2;L3MBTL4;MYCH;NR1H4 |
transcription factor binding | HIF1A;PSMD10;JUNB;TP73;HDAC11;CREBBP;FOXA1;HEY2;ATG7 |
transcription regulatory region DNA binding | SALL1A;POU5F1;CREB3L2;SMAD3;ZFP161;ATF5;NFE2L2;ARRB1;CALCOCO1 |
FOXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXA2.
FOXA1
- Q&As
- Reviews
Q&As (6)
Ask a questionFuture research directions on FOXA2 include in-depth study of its molecular mechanisms in embryonic development and disease development, the development of targeted drugs targeting FOXA2, and the exploration of its application in regenerative medicine and tissue engineering.
The results of FOXA2 research can be used to advance medicine, such as developing diagnostic and therapeutic strategies for developmental defects and tumors, exploring new drug targets, and improving existing treatment options. At the same time, these research results can also be applied to regenerative medicine and tissue engineering for the repair of damaged tissues and organs.
Molecules that interact with FOXA2 include other transcription factors, co-activators, co-repressors, etc. These molecules, together with FOXA2, regulate the expression of downstream genes.
A variety of experimental methods can be used to study the function of FOXA2, including gene knockout, overexpression, chromatin immunoprecipitation (ChIP), reporter gene analysis, and more. These methods can help us gain insight into the role of FOXA2 in embryonic development and disease development.
FOXA2 plays a key role in embryonic development and is involved in regulating processes such as endoderm formation, differentiation of the pancreas and lungs, and development of the digestive tract.
Assessing the quality and reliability of scientific research results for FOXA2 requires the use of scientific methods and standards, including the rationality of experimental design, the accuracy of data processing, and the logic and reproducibility of conclusions. In addition, peer review and quality assessment of papers published in high-level academic journals are required.
Customer Reviews (3)
Write a reviewFOXA2 has strong anti-fouling ability, which effectively avoids the problem of contamination in the experiment.
It has good application performance in immunoassays, such as ELISA, western blotting, etc.
This protein has good fluorescence and absorption properties.
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