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FOXA2

  • Official Full Name

    forkhead box A2

  • Overview

    This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
  • Synonyms

    FOXA2; forkhead box A2; HNF3B; TCF3B; hepatocyte nuclear factor 3-beta; HNF-3B; TCF-3B; HNF-3-beta; forkhead box protein A2; transcription factor 3B; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FOXA2-28944TH Recombinant Human FOXA2 E.coli N/A
Human FOXA2-127H Recombinant Human FOXA2 E.coli N/A
Human FOXA2-6163HCL Recombinant Human FOXA2 293 Cell Lysate HEK293 N/A
Human FOXA2-4433H Recombinant Human FOXA2 Protein, GST-tagged Wheat Germ GST
Human FOXA2-5046HF Recombinant Full Length Human FOXA2 Protein, GST-tagged In Vitro Cell Free System GST 457 amino acids
Mouse FOXA2-5976M Recombinant Mouse FOXA2 Protein Mammalian Cell His
Mouse FOXA2-3314M-B Recombinant Mouse FOXA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Foxa2-1510M Recombinant Mouse Foxa2 Protein, His-tagged E.coli N-His Met1-Ser459
Mouse FOXA2-3314M Recombinant Mouse FOXA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FOXA2-2383R Recombinant Rat FOXA2 Protein Mammalian Cell His
Rat FOXA2-2039R-B Recombinant Rat FOXA2 Protein Pre-coupled Magnetic Beads HEK293
Rat FOXA2-2039R Recombinant Rat FOXA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FOXA2-8588Z Recombinant Zebrafish FOXA2 Mammalian Cell His
Chicken FOXA2-6334C Recombinant Chicken FOXA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FOXA2 Related Articles
  • FOXA2 Related Research Area

FOXA2 involved in several pathways and played different roles in them. We selected most pathways FOXA2 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Maturity onset diabetes of the youngFOXA2;NKX6;HES1;PDX1;HNF1A;HNF1B;NEUROG3;INS1;IAPP

FOXA2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXA2 itself. We selected most functions FOXA2 had, and list some proteins which have the same functions with FOXA2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPROX1A;GEN1;SRFA;ZNF530;NR1D4B;TSG101;HIST1H2AN;HIST1H3A;RORAB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingZIC3;JUN;MIXL1;CARF;ZNF460;RFX4;CRX;NFATC4;RELA
RNA polymerase II transcription factor activity, sequence-specific DNA bindingHIF1AL;ETS1;RUNX2;PLAGL1;OVOL3;LMO2;SOX8;ZSCAN18;SIM1B
protein domain specific bindingHIST4H4;DBNL;IL1B;CENPJ;TJP1;CALM2;CHMP1A;ZBTB16;RAP2B
transcription factor activity, sequence-specific DNA bindingRELB;ZIM3;CEBPD;MYCA;MYC;NKX6-2;L3MBTL4;MYCH;NR1H4
transcription factor bindingHIF1A;PSMD10;JUNB;TP73;HDAC11;CREBBP;FOXA1;HEY2;ATG7
transcription regulatory region DNA bindingSALL1A;POU5F1;CREB3L2;SMAD3;ZFP161;ATF5;NFE2L2;ARRB1;CALCOCO1

FOXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXA2.

FOXA1

Liang, S; Li, HC; et al. Pulmonary endoderm, second heart field and the morphogenesis of distal outflow tract in mouse embryonic heart. DEVELOPMENT GROWTH & DIFFERENTIATION 56:276-292(2014).
Reers, S; Pfannerstill, AC; et al. Stem cell profiling in head and neck cancer reveals an Oct-4 expressing subpopulation with properties of chemoresistance. ORAL ONCOLOGY 50:155-162(2014).
  • Q&As
  • Reviews

Q&As (6)

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What are the future research directions for FOXA2? 04/21/2023

Future research directions on FOXA2 include in-depth study of its molecular mechanisms in embryonic development and disease development, the development of targeted drugs targeting FOXA2, and the exploration of its application in regenerative medicine and tissue engineering.

How can the results of FOXA2 be used to advance medicine? 10/22/2022

The results of FOXA2 research can be used to advance medicine, such as developing diagnostic and therapeutic strategies for developmental defects and tumors, exploring new drug targets, and improving existing treatment options. At the same time, these research results can also be applied to regenerative medicine and tissue engineering for the repair of damaged tissues and organs.

What are the molecules that interact with FOXA2? 04/09/2022

Molecules that interact with FOXA2 include other transcription factors, co-activators, co-repressors, etc. These molecules, together with FOXA2, regulate the expression of downstream genes.

How can I study the features of FOXA2? 11/17/2021

A variety of experimental methods can be used to study the function of FOXA2, including gene knockout, overexpression, chromatin immunoprecipitation (ChIP), reporter gene analysis, and more. These methods can help us gain insight into the role of FOXA2 in embryonic development and disease development.

Does FOXA2 have a function in embryonic development? 01/14/2021

FOXA2 plays a key role in embryonic development and is involved in regulating processes such as endoderm formation, differentiation of the pancreas and lungs, and development of the digestive tract.

How do you assess the quality and reliability of research results for FOXA2? 01/23/2020

Assessing the quality and reliability of scientific research results for FOXA2 requires the use of scientific methods and standards, including the rationality of experimental design, the accuracy of data processing, and the logic and reproducibility of conclusions. In addition, peer review and quality assessment of papers published in high-level academic journals are required.

Customer Reviews (3)

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Reviews
03/21/2023

    FOXA2 has strong anti-fouling ability, which effectively avoids the problem of contamination in the experiment.

    05/16/2022

      It has good application performance in immunoassays, such as ELISA, western blotting, etc.

      06/25/2021

        This protein has good fluorescence and absorption properties.

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