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FOXC1

Official Full Name

forkhead box C1
Overview

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
Synonyms

FOXC1; forkhead box C1; ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3; forkhead box protein C1; myeloid factor-delta; forkhead box C1 protein; forkhead-related activator 3; forkhead-related protein FKHL7; forkhead, drosophila, homolog-like 7; forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FOXC1-6161HCL	Recombinant Human FOXC1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FOXC1-4437H	Recombinant Human FOXC1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	FOXC1-5980M	Recombinant Mouse FOXC1 Protein	Mammalian Cell	His		Inquiry
Mouse	Foxc1-7634M	Recombinant Mouse Foxc1 protein, His-tagged	E.coli	His	Arg62~Lys186 (Accession # Q61572)	Inquiry
Mouse	FOXC1-3317M-B	Recombinant Mouse FOXC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	FOXC1-3317M	Recombinant Mouse FOXC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	FOXC1-6564C	Recombinant Chicken FOXC1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FOXC1 Related Articles

FOXC1 involved in several pathways and played different roles in them. We selected most pathways FOXC1 participated on our site, such as Heart Development, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Heart Development	TBX5;FOXC1;IRX4;HEY1;BMP10;GATA6;NKX2-5;TBX20;SMYD1

FOXC1 has several biochemical functions, for example, DNA binding, DNA binding, bending, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXC1 itself. We selected most functions FOXC1 had, and list some proteins which have the same functions with FOXC1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	POU3F3;SPRTN;H2AFB1;NFAT5A;CERS2A;ZFP628;MAFBA;EN2;CIC
DNA binding, bending	TOP2B;SRY;FOXI1;FOXC1;TOP2A;LEF1;FOXD1;HHEX;HMGB2
RNA polymerase II regulatory region sequence-specific DNA binding	KLF12;BHLHA15;PHF21A;ATF5;SKINT8;ATF4B1;HOXD9;ZBTB16A;E2F7
RNA polymerase II transcription factor activity, sequence-specific DNA binding	SOX9B;TFDP3;OVOL2;MED1;MITFA;RELB;FOXO4;SOX8;ZNF576
protein binding	EFHA1;VEGFB;HELZ;MAP3K4;HSPB6;SEC23B;AVPR1A;ZNF624;NR5A1
sequence-specific DNA binding	HOXA7;NKX2-3;DLX2A;FOXO3B;BARHL1B;FOXB1B;SMAD3;IRX4B;HOXC8
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	PURA;THRA;USF1;BHLHE40;ATF1;OLIG2;MEIS1;LEF1;MEF2C
transcription factor activity, sequence-specific DNA binding	NTNG1;ZFP367;LHX1;GPBP1L1;FOXG1A;FOXC1A;SLC30A9;EGR2;RELA
transcription factor binding	PDCD11;JUND;SIRT2;GATA2;STK4;DRAP1;PAX6;ARRB1;RARA
transcription regulatory region DNA binding	GATA4;ZNF174;WT1;OVOL2;RELA;CREB3L2;WNT5A;PAX2;KDM1A
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GABPA;CTCF;FOXO3;MYOD1;CSRNP2;IKZF3;PLAGL1;BARHL1A;MAFBA

FOXC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXC1.

FLNA; PBX1; C1QBP; PITX2

Sadagopan, KA; Liu, GT; et al. Anirdia-Like Phenotype Caused by 6p25 Dosage Aberrations. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:524-528(2015).

Yoshimura-Furuhata, M; Nishimura-Tadaki, A; et al. Renal Complications in 6p Duplication Syndrome: Microarray-Based Investigation of the Candidate Gene(s) for the Development of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) and Focal Segmental Glomerular Sclerosis (FSGS). AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:592-601(2015).