FOXM1
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Official Full Name
forkhead box M1
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Overview
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] -
Synonyms
FOXM1; forkhead box M1; MPP2; TGT3; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2; forkhead box protein M1; M-phase phosphoprotein 2; HNF-3/fork-head homolog 11; transcription factor Trident; MPM-2 reactive phosphoprotein 2; forkhead-related protein FKHL16; winged-helix factor from INS-1 cells; Forkhead, drosophila, homolog-like 16; hepatocyte nuclear factor 3 forkhead homolog 11;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- GST|His
- His|SUMO|Myc
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | FOXM1-1215H | Recombinant Human FOXM1 Protein, His-SUMO/MYC-tagged | E.coli | His/SUMO/Myc | ||
Human | FOXM1-6152HCL | Recombinant Human FOXM1 293 Cell Lysate | HEK293 | N/A | ||
Human | FOXM1-6153HCL | Recombinant Human FOXM1 293 Cell Lysate | HEK293 | N/A | ||
Human | FOXM1-5098HF | Recombinant Full Length Human FOXM1 Protein, GST-tagged | In Vitro Cell Free System | GST | 748 amino acids | |
Human | FOXM1-4464H | Recombinant Human FOXM1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | FOXM1-2560H | Recombinant Human FOXM1 Protein, GST/His-tagged | E.coli | GST/His | ||
Human | FOXM1-3162H | Recombinant Human FOXM1 protein, His-tagged | E.coli | His | 91-237 aa | |
Human | FOXM1-1964HFL | Recombinant Full Length Human FOXM1 Protein, N-GST/C-His-tagged | E.coli | GST/His | ||
Human | FOxM1-1346H | Recombinant Human FOxM1 protein, GST-tagged | E.coli | GST | 222-360aa | |
Mouse | Foxm1-1522M | Recombinant Mouse Foxm1 Protein, His-tagged | E.coli | N-His | Cys208-Glu460 | |
Rat | Foxm1-7640R | Recombinant Rat Foxm1 protein, His & T7-tagged | E.coli | His/T7 | Cys209~Gly460 (Accession # P97691) | |
Zebrafish | FOXM1-11319Z | Recombinant Zebrafish FOXM1 | Mammalian Cell | His | ||
Chicken | FOXM1-2166C | Recombinant Chicken FOXM1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- FOXM1 Related Articles
- FOXM1 Related Research Area
FOXM1 involved in several pathways and played different roles in them. We selected most pathways FOXM1 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1 associated events during G2/M transition, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell Cycle | ANAPC4;GORASP2;NCAPD3;PANE1;CCNE2;PCNA;CNEP1R1;NDEL1B;MYCB |
Cell Cycle, Mitotic | NSL1;CP110;CENPP;MCPH1;NCAPG;CENPN;GINS1;CSNK2A2;CEP290 |
Cyclin A/B1 associated events during G2/M transition | FOXM1;CDK7 |
FOXM1 transcription factor network | CKS1B;CENPA;CHEK2;CENPB;FOXM1;AURKB |
G2/M Transition | TUBGCP2;DYNC1I2;TCTN2;NUMA1;SSNA1;PLK4;TUBGCP3;CEP152;TUBGCP5 |
Mitotic G2-G2/M phases | TUBGCP3;TUBGCP5;CDK11B;TUBGCP2;TUBG2;CDK11A;FOXM1;LIN37;NUMA1 |
Polo-like kinase mediated events | LIN9;LIN37;FOXM1;LIN52 |
SIDS Susceptibility Pathways | SST;DLX2;TPH2;MAZ;GATA2;PKNOX1;DEAF1;YBX1;SCN3B |
FOXM1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXM1 itself. We selected most functions FOXM1 had, and list some proteins which have the same functions with FOXM1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | KRBA2;TRIM33;PTGES2;TBX2B;PPP1R8;ZNF490;ZNF334;DLX2A;DOT1L |
RNA polymerase II transcription factor activity, sequence-specific DNA binding | RUNX2;FOXO3;FOXI3A;TFAP2A;EOMESA;FOXJ1A;SOX8B;SIM2;PLAGX |
protein binding | WWP1;APOA2;TRMT2B;SHPRH;RNF146;COMMD8;IQSEC3;LSM8;ALKBH4 |
protein kinase binding | RHEB;PLK1S1;PDCD10;PTEN;CALM2;MAPK8IP2;TNNI3;EEF1A1;SKI |
sequence-specific DNA binding | UNCX;DBX1A;UNCX4.1;ZNF232;HOXA3;IRX4A;HOXC5;SOX13;ISL2A |
transcription factor activity, sequence-specific DNA binding | FLI1;KLF12;TADA3;FOXI3A;TEAD2;SCMH1;DMRT3A;TBX10;GRHL2A |
transcription regulatory region DNA binding | IKZF2;HMGB2;HOXA13;RELA;CTNNB1;FOXA1;NFE2L2;PPARG;HIVEP3 |
FOXM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXM1.
CTNNB1; TCF7L2
- Q&As
- Reviews
Q&As (6)
Ask a questionThe structure of FOXM1 determines its ability to bind to DNA and regulate transcription. The study of its structure can help us understand its function and mechanism of action.
Studies have shown that the expression level of FOXM1 is associated with the occurrence and development of a variety of diseases, including cancer, cardiovascular disease, and neurodegenerative diseases.
The expression level of FOXM1 can be detected by immunohistochemistry, western blot and real-time quantitative PCR.
Studies have shown that the expression level of FOXM1 is upregulated in some cancers, which may promote the occurrence and development of cancer. It could be a potential target for cancer treatment.
Drug development for FOXM1 requires consideration of its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.
FOXM1 can interact with a variety of other proteins, including transcription factors and proteins in signal transduction pathways. These interactions enable it to regulate processes such as cell proliferation, differentiation, and apoptosis.
Customer Reviews (3)
Write a reviewStable performance in common colorimetric reactions.
The quality of the FOXM1 is consistent and reassuring.
Under the influence of temperature, humidity and light, this protein has good stability and persistence.
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