FRS2
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Official Full Name
fibroblast growth factor receptor substrate 2
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Overview
Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene. -
Synonyms
FRS2; fibroblast growth factor receptor substrate 2; FRS2A; FRS2alpha; SNT 1; SNT1; FGFR signaling adaptor SNT; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; FRS 2; FRS2_HUMAN; SNT; SNT-1; Suc 1 Associated Neurotrophic Factor Target; Suc1 associated neurotrophic factor target 1; Suc1-associated neurotrophic factor target 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- FRS2 Related Articles
- FRS2 Related Gene Family
- FRS2 Related Research Area
- FRS2 Related Signal Pathway
FRS2 involved in several pathways and played different roles in them. We selected most pathways FRS2 participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FRS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | RASGRP4;DAB2IPB;PAQR3B;KBTBD7;DUSP1;NRG2A;RASGEF1A;CSF2RB;RASGRP1 |
| Adaptive Immune System | CXADR;UBE2J2;CD160;LILRA1;RAPGEF4;FCGR1B;AP1B1;TRIM9;UBE2V2 |
| Axon guidance | SEMA4C;CLTA;NRG3;PHB;RHOD;SCN3A;Unc5b;TRPC5;SIAH2 |
| BDNF signaling pathway | CDH2;MAP3K2;FRS2;LINGO1;DPYSL2;FRS3;JAK2;CNR1;CFL1 |
| Constitutive Signaling by Aberrant PI3K in Cancer | NRG4;HBEGF;NRG3;FRS2;TRAT1;KLB;EGF |
| Cytokine Signaling in Immune system | TAB1;SPRED2;FGF18B;KPNA4;GBP1;SPTBN2;ARIH1L;EIF4G1;TNIP2 |
| DAP12 interactions | DUSP10;FGF10B;FGF20A;PHB;MARK3;JAK1;CD300E;DUSP1;GRAP2B |
| DAP12 signaling | NEFLB;NRG2A;DUSP5;DUSP7;FGFR1B;PRKAR1AA;TRAT1;FRS3;GRAP2A |
FRS2 has several biochemical functions, for example, fibroblast growth factor receptor binding, insulin receptor binding, neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FRS2 itself. We selected most functions FRS2 had, and list some proteins which have the same functions with FRS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibroblast growth factor receptor binding | FGF2;FGF18B;FGF18A;FGF3;FGF10A;FGF6;FGF8B;FGF6B;FGF20A |
| insulin receptor binding | DOK4;FRS2B;IRS2;INSL3;SNX4;IRS1;IGF1R;FRS2;SHC1 |
| neurotrophin TRKA receptor binding | SHC1;FRS2;NGFR;PIK3R1;PLCG1;GRB2;EFNA5 |
| phosphatase activator activity | BMP2;FRS2;GTF2F1 |
| protein binding | SREK1IP1;NR0B1;ADAMTS4;GRIA2;EIF1AX;SIAH2;C14orf159;MYL12A;RNF135 |
| transmembrane receptor protein tyrosine kinase adaptor activity | STAP1;FRS2;SH2B2;DOK2;PIK3R1;BLNK;TRAT1;SHC1;IRS1 |
FRS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FRS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FRS2.
PTPN11; RPS6; BECN1; suc1; FGFR1; GRB2; SH2B1; Coro1c
- Q&As
- Reviews
Q&As (6)
Ask a questionFRS2 protein regulates signal transduction of insulin receptors, so its abnormal expression or function can lead to the pathogenesis of insulin resistance.
FRS2 plays an important role in the proliferation and differentiation of hepatocytes, and no good regulation will lead to hepatocyte transformation and carcinogenesis.
FRS2 protein can be considered a potential target for the treatment of certain types of cancer, so drug research is expected to further explore this effect.
The bone metabolism regulated by FRS2 protein is related to bone formation and bone resorption, and plays a role by affecting the signaling and function of bone cells.
The protein can affect insulin metabolism by binding to insulin receptors and other proteins to regulate downstream signaling of insulin receptors.
Defects in the FRS2 protein can lead to the development of pathopathologies such as insulin resistance, obesity, bone metabolism disorders, and neurodegenerative diseases.
Customer Reviews (3)
Write a reviewThe catalytic activity of FRS2 is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.
Stability of FRS2 is very high, and it can maintain stable performance even in extreme environments, which shows its excellent adaptability and reliability.
The production process of FRS2 uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, bringing a positive impact on the environment.
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