FUT8
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Official Full Name
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
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Overview
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. -
Synonyms
FUT8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); alpha-(1,6)-fucosyltransferase; 6)-fucosyltransferase; 6-fucosyltransferase; Alpha (1,6) fucosyltransferase; Alpha-(1; Alpha1 6FucT; alpha1-6FucT; Fucosyltransferase 8; FUT8_HUMAN; GDP fucose glycoprotein fucosyltransferase; GDP L Fuc:N acetyl beta D glucosaminide alpha1,6 fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1; Glycoprotein 6 alpha L fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Hamster
- Human
- Mouse
- Rat
- Rhesus Macaque
- Sus scrofa (Pig)
- CHO
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- 6×His, GFP
- Involved Pathway
- Protein Function
- Interacting Protein
- FUT8 Related Articles
FUT8 involved in several pathways and played different roles in them. We selected most pathways FUT8 participated on our site, such as N-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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N-Glycan biosynthesis | MGAT4B;MAN1A;ALG6;ST6GAL2A;RABGNT1;DPM2;TUSC3;ALG10;B4GALT3 |
Glycosaminoglycan biosynthesis - keratan sulfate | CHST2;B3GNT2;B4GALT2;B3GNT7;CHST6;CHST2A;CHST4;Chst5;B4GALT1 |
Metabolic pathways | PTDSS1A;ST3GAL3;HPDA;TM7SF2;HYAL6;HSD3B6;MTMR4;GALNT7;CHKA |
Transcriptional misregulation in cancer | BMP2K;SMAD1;Itgam&Itgb2;HDAC1;NFKBIZ;TGFBR2;FLT1;DEFA3;ITGAM |
FUT8 has several biochemical functions, for example, SH3 domain binding, glycoprotein 6-alpha-L-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT8 itself. We selected most functions FUT8 had, and list some proteins which have the same functions with FUT8. You can find most of the proteins on our site.
Function | Related Protein |
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SH3 domain binding | CD2AP;GJA1;EVL;LRP2;KHDRBS1;ELMO2;CBLC;SHANK2;NCF1 |
glycoprotein 6-alpha-L-fucosyltransferase activity | FUT8A;FUT8 |
FUT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT8.
env; dAK1_1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, altering FUT8 activity can impact cancer cell growth and metastasis, making it a potential target for cancer therapies.
One challenge is the specificity of FUT8 inhibitors, ensuring they do not affect other essential glycosylation processes in the body.
Yes, abnormal glycosylation patterns due to FUT8 alterations can serve as biomarkers for diseases like cancer, aiding in early diagnosis.
FUT8-mediated glycosylation of antibodies can enhance their stability and effector functions, making them more effective in treating diseases like cancer and autoimmune disorders.
Yes, deficiencies in FUT8 have been associated with certain types of cancers and developmental disorders.
Customer Reviews (3)
Write a reviewWith the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.
Researchers who have utilized the FUT8 protein laud its reliability and effectiveness in their studies.
Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.
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