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FUT8

  • Official Full Name

    fucosyltransferase 8 (alpha (1,6) fucosyltransferase)

  • Overview

    This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.
  • Synonyms

    FUT8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); alpha-(1,6)-fucosyltransferase; 6)-fucosyltransferase; 6-fucosyltransferase; Alpha (1,6) fucosyltransferase; Alpha-(1; Alpha1 6FucT; alpha1-6FucT; Fucosyltransferase 8; FUT8_HUMAN; GDP fucose glycoprotein fucosyltransferase; GDP L Fuc:N acetyl beta D glucosaminide alpha1,6 fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1; Glycoprotein 6 alpha L fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Hamster
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • CHO
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • 6×His, GFP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FUT8-2518H Active Recombinant Human FUT8, His tagged Insect Cell His Arg 68-Lys 575
Human FUT8-577H Active Recombinant Human Fucosyltransferase 8 (alpha (1, 6) fucosyltransferase), His-tagged CHO His
Human FUT8-27230TH Recombinant Human FUT8 Wheat Germ N/A 575 amino acids
Human FUT8-497HCL Recombinant Human FUT8 cell lysate Insect Cell N/A
Human FUT8-518H Recombinant Human FUT8 protein, His-tagged E. coli His 276-575 aa
Human FUT8-4567H Recombinant Human FUT8 Protein, GST-tagged Wheat Germ GST
Human FUT8-2659H Recombinant Human FUT8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FUT8-6301H Recombinant Human FUT8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FUT8-5111H Recombinant Human FUT8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FUT8-171HF Recombinant Full Length Human FUT8 Protein In Vitro Cell Free System 575 amino acids
Human FUT8-5196HF Recombinant Full Length Human FUT8 Protein, GST-tagged In Vitro Cell Free System GST 575 amino acids
Human FUT8-31H Active Recombinant Human FUT8 Protein (AA 41-575), N-6×His/GFP tagged HEK293 N-6×His, GFP AA 41-575
Mouse FUT8-6095M Recombinant Mouse FUT8 Protein Mammalian Cell His
Mouse Fut8-1413M Recombinant Mouse Fut8 protein, His-tagged E.coli His Lys206~Lys575
Mouse FUT8-3394M Recombinant Mouse FUT8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fut8-3110M Recombinant Mouse Fut8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FUT8-3394M-B Recombinant Mouse FUT8 Protein Pre-coupled Magnetic Beads HEK293
Rat FUT8-2415R Recombinant Rat FUT8 Protein Mammalian Cell His
Rat FUT8-2071R Recombinant Rat FUT8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FUT8-2071R-B Recombinant Rat FUT8 Protein Pre-coupled Magnetic Beads HEK293
Hamster FUT8-326H Recombinant Hamster Fut8, His tagged Insect Cell His
Hamster FUT8-001HCL Recombinant Hamster FUT8 cell lysate Insect Cell N/A
Rhesus Macaque FUT8-1769R Recombinant Rhesus monkey FUT8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FUT8-1590R Recombinant Rhesus Macaque FUT8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FUT8-1590R-B Recombinant Rhesus Macaque FUT8 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL23496SF Recombinant Full Length Pig Alpha-(1,6)-Fucosyltransferase(Fut8) Protein, His-Tagged E.coli expression system His Full Length (1-575)
Chicken FUT8-1237C Recombinant Chicken FUT8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FUT8 Related Articles

FUT8 involved in several pathways and played different roles in them. We selected most pathways FUT8 participated on our site, such as N-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
N-Glycan biosynthesisMGAT4B;MAN1A;ALG6;ST6GAL2A;RABGNT1;DPM2;TUSC3;ALG10;B4GALT3
Glycosaminoglycan biosynthesis - keratan sulfateCHST2;B3GNT2;B4GALT2;B3GNT7;CHST6;CHST2A;CHST4;Chst5;B4GALT1
Metabolic pathwaysPTDSS1A;ST3GAL3;HPDA;TM7SF2;HYAL6;HSD3B6;MTMR4;GALNT7;CHKA
Transcriptional misregulation in cancerBMP2K;SMAD1;Itgam&Itgb2;HDAC1;NFKBIZ;TGFBR2;FLT1;DEFA3;ITGAM

FUT8 has several biochemical functions, for example, SH3 domain binding, glycoprotein 6-alpha-L-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT8 itself. We selected most functions FUT8 had, and list some proteins which have the same functions with FUT8. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingCD2AP;GJA1;EVL;LRP2;KHDRBS1;ELMO2;CBLC;SHANK2;NCF1
glycoprotein 6-alpha-L-fucosyltransferase activityFUT8A;FUT8

FUT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT8.

env; dAK1_1

Li, WZ; Yu, R; et al. Core Fucosylation of IgG B Cell Receptor Is Required for Antigen Recognition and Antibody Production. JOURNAL OF IMMUNOLOGY 194:2596-2606(2015).
Wang, YQ; Fukuda, T; et al. Loss of alpha 1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling. SCIENTIFIC REPORTS 5:-(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can manipulating FUT8 protein have implications in cancer therapy? 03/27/2021

Yes, altering FUT8 activity can impact cancer cell growth and metastasis, making it a potential target for cancer therapies.

Are there any challenges in targeting FUT8 protein for therapeutic interventions? 08/23/2019

One challenge is the specificity of FUT8 inhibitors, ensuring they do not affect other essential glycosylation processes in the body.

Can FUT8 protein modifications be used as biomarkers for certain diseases? 11/30/2018

Yes, abnormal glycosylation patterns due to FUT8 alterations can serve as biomarkers for diseases like cancer, aiding in early diagnosis.

How does FUT8 protein impact the development of therapeutic antibodies? 11/05/2016

FUT8-mediated glycosylation of antibodies can enhance their stability and effector functions, making them more effective in treating diseases like cancer and autoimmune disorders.

Are there any diseases directly linked to FUT8 protein deficiency? 03/12/2016

Yes, deficiencies in FUT8 have been associated with certain types of cancers and developmental disorders.

Customer Reviews (3)

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Reviews
04/01/2021

    With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

    06/30/2020

      Researchers who have utilized the FUT8 protein laud its reliability and effectiveness in their studies.

      05/12/2017

        Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.

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