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FXR1

  • Official Full Name

    fragile X mental retardation, autosomal homolog 1

  • Overview

    Fragile X mental retardation-related protein 1 (FXR1) and FXR2 are members of the FMR1 family sharing a very high degree of protein similarity among them. They interact with each other and also with FMR1, moving between the cytoplasm and the nucleus. FXR1 is an RNA binding protein and is expressed in the heart, kidney, brain, and testis. Mutations in FMR1 result in the most common form of mental retardation.
  • Synonyms

    FXR1; fragile X mental retardation, autosomal homolog 1; fragile X mental retardation syndrome-related protein 1; hFXR1p; FXR1P;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FXR1-13052H Recombinant Human FXR1 protein, GST-tagged E.coli GST 1-353 aa
Human FXR1-941H Recombinant Human FXR1 protein, GST-tagged Wheat Germ GST
Human FXR1-6106HCL Recombinant Human FXR1 293 Cell Lysate HEK293 N/A
Human FXR1-13053H Recombinant Human FXR1 protein, His-tagged E.coli His 1-353 aa
Human FXR1-587HF Recombinant Full Length Human FXR1 Protein, GST-tagged In Vitro Cell Free System GST 621 amino acids
Human FXR1-2782H Recombinant Human FXR1 protein(221-480 aa), C-His-tagged E. coli C-His 221-480 aa
Mouse FXR1-6101M Recombinant Mouse FXR1 Protein Mammalian Cell His
Mouse FXR1-3399M-B Recombinant Mouse FXR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse FXR1-3399M Recombinant Mouse FXR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FXR1-2419R Recombinant Rat FXR1 Protein Mammalian Cell His
Rat FXR1-2075R-B Recombinant Rat FXR1 Protein Pre-coupled Magnetic Beads HEK293
Rat FXR1-2075R Recombinant Rat FXR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Fxr1-1538R Recombinant Rat Fxr1 Protein, His&GST-tagged E.coli N-His&GST Leu375-Asp568
Zebrafish FXR1-11449Z Recombinant Zebrafish FXR1 Mammalian Cell His
Chicken FXR1-1971C Recombinant Chicken FXR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FXR1 Related Articles

FXR1 involved in several pathways and played different roles in them. We selected most pathways FXR1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with FXR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA transportEEF1A1B;CYFIP2;NUP210L;POM121L2;SIP1;UPF3B;EIF3HA;THOC4;NUP188

FXR1 has several biochemical functions, for example, G-quadruplex RNA binding, RNA binding, mRNA 3-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FXR1 itself. We selected most functions FXR1 had, and list some proteins which have the same functions with FXR1. You can find most of the proteins on our site.

Function Related Protein
G-quadruplex RNA bindingAff2;DHX36;FXR1;PATL2
RNA bindingNANOS3;SFPI1;DAZAP1;RPL5;SRSF1A;ZMAT4;CNOT7;CSDC2;IGF2BP2A
mRNA 3-UTR bindingTARDBP;SECISBP2;RBMS3;LARP1;PUM1;RIMS2;YBX2;CPEB4;CSDA
mRNA bindingRPL35;NUDT21;CLUHA;RPS26;C1QBP;RBPMS2B;CSTF2T;RBMX;RBFOX1
poly(A) RNA bindingMRPL1;HELZ2;YTHDF1;LSM4;EXOSC9;AKAP1;EIF2S1;RALYL;ZFP106

FXR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FXR1.

CSNK2A1; PRSS23; HSPB1; GBP2; CRMP1; HABP4; q5nig6_fratt; RIF1; CYFIP2; CEP126; C14orf1; LUC7L2; UBA6; Max; ssrna_ug

Say, E; Tay, HG; et al. A Functional Requirement for PAK1 Binding to the KH(2) Domain of the Fragile X Protein-Related FXR1. MOLECULAR CELL 38:236-249(2010).
Hofmann, I; Casella, M; et al. Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. MOLECULAR BIOLOGY OF THE CELL 17:1388-1398(2006).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What potential therapeutic applications arise from targeting FXR1 in muscular disorders? 10/20/2022

Targeting FXR1 could offer therapeutic strategies for treating muscle disorders linked to RNA metabolism abnormalities.

What is the primary role of FXR1 in RNA metabolism? 07/24/2022

FXR1, an RNA-binding protein, is involved in regulating RNA metabolism, particularly mRNA processing and turnover.

How does FXR1 interact with other RNA-binding proteins? 09/23/2021

FXR1 interacts with a network of RNA-binding proteins, coordinating the regulation of mRNA metabolism.

What role does FXR1 play in protein synthesis? 09/06/2021

FXR1 plays a crucial role in modulating protein synthesis by influencing mRNA availability and translation.

How does FXR1 contribute to mRNA stability? 03/22/2020

It contributes to mRNA stability, affecting the lifespan and translation efficiency of mRNAs.

What is the impact of altered FXR1 activity on muscle development? 01/29/2020

Altered FXR1 activity can affect muscle development and function, potentially leading to muscle-related disorders.

How do genetic variations in FXR1 affect cellular processes? 06/08/2019

Genetic mutations in FXR1 can disrupt normal RNA processing and protein synthesis, impacting various cellular functions.

Customer Reviews (3)

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Reviews
06/08/2023

    Highly recommended service, valuable for research projects.

    02/08/2022

      Exceptional expertise, elevates our research standards.

      02/18/2021

        Dependable results, a key to research success.

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