FASLG
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Official Full Name
Fas ligand (TNF superfamily, member 6)
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Overview
The Fas receptor (FasR) is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is also known as CD95, Apo-1, and tumor necrosis factor receptor superfamily, member 6 (TNFRSf6). FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution are found in most mammals. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). -
Synonyms
FASLG; Fas ligand (TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95 ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; soluble form; APO1L; Apoptosis antigen ligand 1; CD178 antigen; CD95; L CD95L protein; Fas L; Fas ligand; Fasl Fas ligand (TNF superfamily member 6); Generalized lymphoproliferative disease; Gld; TNF superfamily member 6; TNFL6_HUMAN; Fas-L;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus monkey
- Cynomolgus Monkey
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Macaca nemestrina (Pig-tailed macaque)
- Mouse
- Mus musculus (Mouse)
- Pig
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Rhesus monkey
- Zebrafish
- CHO
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- Fc
- Flag
- FLAG
- GST
- HA
- His (Fc)
- Avi
- His|GST
- His|S
- His|T7
- N/A
- N
- SUMO
- MBP
- Involved Pathway
- Protein Function
- Interacting Protein
- FASLG Related Articles
- FASLG Related Gene Family
- FASLG Related Research Area
- FASLG Related Signal Pathway
FASLG involved in several pathways and played different roles in them. We selected most pathways FASLG participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FASLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | NFATC3;RPS6KA4;MAPK8IP3;MAP2K5;MAP3K7;CACNB3A;MAP3K4;HSPA1L;FGFR3 |
| Ras signaling pathway | PAK3;GNG13;NF1;FGF3;RRAS;RHOA;ETS1;GNG3;FGF13 |
| Cytokine-cytokine receptor interaction | IL1B;IL6;IL1A;CD70;IL23R;TNFSF13B;CCL17;CXCL10;ACVR2A |
| FoxO signaling pathway | IGF1R;TGFBR1A;HOMER3;PLK3;MAPK1;INSRB;PRKAG2;MAP2K2A;GADD45AA |
| PIK-Akt signaling pathway | LPAR4;FLT4;LPAR3;IFNAR1;PIK3CA;VTN;CCNE1;IFNA17;IFNA1 |
| Apoptosis | DIABLO;DFFB;IL1B;DBNLA;BAXB;IL1B2;NGF;CDKN2A;PIK3R3A |
| Natural killer cell mediated cytotoxicity | KIR2DL1;RAC3;SH3BP2;IFNA14;FCGR3;RAC1;LCK;HLA-C;PPP3CA |
| Neurotrophin signaling pathway | PTPN11;BAX;NFKB1;SHC2;MAP3K5;HRAS;MAPK11;MAP3K1;NGFR |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFS2;FASLG;CEBPA;NDUFC2-KCTD14;MLXIPL;NDUFA13;UQCRC2;UQCRB;SOCS3 |
| Type I diabetes mellitus | PTPRN2;HLA-F;PTPRN;HLA-DRB5;HLA-DQA1;HLA-DRB3;HLA-DRB4;CD80;HSPD1 |
| Chagas disease (American trypanosomiasis) | FAS;FADD;FOS;PPP2R1B;ACE;IL10;PPP2R2C;C1QB;PLCB2 |
| African trypanosomiasis | HBB-B2;IL1B2;PLCB4;TNF;SELE;APOA1;HBB;IDO2;ICAM1 |
| Hepatitis B | NFATC1;PRKCA;PIK3R1;IL6;MYD88;ATF4;IRF3;SMAD4;BAX |
| Measles | IL2RA;IFNA4;IFNGR1;Fasl;IRF7;PIK3CB;RAB9B;MYD88;IFNA1 |
| Influenza A | NFKBIB;CPSF4;CYCS;PRSS2;OAS1;EIF2AK3;IFNA7;NXF3;IFNA10 |
| Herpes simplex infection | HLA-DQA2;SRSF1B;TAF3;OAS1A;SRPK1A;ALYREF;CDC34A;NFKBIAB;H2-AB1 |
| Pathways in cancer | LAMA3;CKS2;MAX;MAPK3;GNGT2;LAMC2;BIRC3;RASSF5;DAPK1 |
| Proteoglycans in cancer | MAPK12;SLC9A1;WNT11;RRAS2;PPP1CB;ERBB2;RDX;FZD6;HSPG2 |
| Autoi | Fasl;Ifna15;H2-Q10;IFNA16;IFNA2;HLA-E;HLA-DQA2;TG;IFNA10 |
| ne thyroid disease | HLA-DRB4;IL5;CD40LG;IFNA17;HLA-DRB1;HLA-DQB1;H2-AA;IFNA5;PRF1 |
| Allograft rejection | MICA;H2-Q10;HLA-DQA1;HLA-DRB3;HLA-DOB;FAS;IL12A;PRF1;HLA-DRA |
| Graft-versus-host disease | HLA-A;HLA-DQA1;HLA-DRB4;FASLG;CD80;HLA-DRB3;KLRC1;H2-AA;Il2 |
FASLG has several biochemical functions, for example, cytokine activity, death receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FASLG itself. We selected most functions FASLG had, and list some proteins which have the same functions with FASLG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IFNA13;BMP8A;Ccl12;IL5;INHBA;EDN1;GDF10;IL21;IFNA8 |
| death receptor binding | CASP8;Fasl;PIDD1;NOL3;Casp3;FADD;TNFSF15;MYD88;CFLAR |
| protein binding | POLM;MID1IP1;RNF220;UBQLN1;KCNQ5;MAPK8IP2;NRCAM;LANCL1;VTN |
| receptor binding | FGF20A;GNPAT;PVRL2;HLA-F;YES1;CADM2;DHRS4;ADAM10;RASA1 |
| tumor necrosis factor receptor binding | FADD;BRE;CD70;TNFSF10;TNFSF12;TNFSF10L3;TNF;CD40LG;TNFSF4 |
FASLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASLG here. Most of them are supplied by our site. Hope this information will be useful for your research of FASLG.
PSTPIP1; FAS; FADD; CASP8; SRGAP2; FYN
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are diagnostic tests that measure FASLG levels, which can provide insights into immune function and disease processes.
The FASLG protein can be targeted for therapeutic purposes in cancer treatment and autoimmune disease management.
Dysregulation of FASLG expression can contribute to liver injury and the progression of liver diseases such as hepatitis and liver fibrosis.
Dysregulation of FASLG expression can impact intestinal immune homeostasis and contribute to the pathogenesis of inflammatory bowel disease.
FASLG is involved in the regulation of immune responses to transplanted organs, and its dysregulation can impact transplant outcomes.
Customer Reviews (3)
Write a reviewThe outstanding level of customer service adds extra reassurance and confidence in using the FASLG protein for my scientific investigations.
the manufacturer of FASLG provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.
The FASLG protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.
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