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FCGR1A

  • Official Full Name

    Fc fragment of IgG, high affinity Ia, receptor (CD64)

  • Overview

    CD64 is the high-affinity IgG Fc receptor belonging to the immunoglobulin supergene family (Guyre, 2002). CD64 is a 72 kDa glycoprotein which binds monomeric IgG (human IgG1>IgG3>>IgG4>>>IgG2 and mouse IgG3>IgG2a>>>IgG1, IgG2b). Three genes: FcgammaR1A, FcgammaR1B and FcgammaR1C, which have >98 percent identity at the nucleotide level, have been identified and mapped to chromosome 1, band q21.1 (Sun,1997)). The FcgammaR1A gene, which specified the high-affinity IgG receptor, encodes three C2-type Ig-like extracellular domains, a 21 amino acid transmembrane region, and a charge cytoplasmic tail of 61 amino acids (Sun, 1997)(van de Winkel,1993).
  • Synonyms

    FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64); high affinity immunoglobulin gamma Fc receptor I; Fc receptor, IgG, high affinity I; high affinity IgG Fc receptor, subunit beta; Fc fragment of IgG high affinity Ib receptor; high-affinity immunoglobulin gamma Fc receptor I; Fc fragment of IgG, high affinity Ib, receptor for (CD64); Fcgr1; Fcgr1b; FcgammaRI;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Rabbit
  • Rat
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • Human
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • Avi|His
  • C
  • His
  • DYKDDDDK
  • Fc
  • GST
  • His|Avi
  • Avi
  • mIgG1
  • mIgG2a
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FCGR1A-3817H Active Recombinant Human FCGR1A Protein, Avi/His-tagged, biotinylated HEK293 Avi/His Met 1-Thr 287
Human FCGR1A-179H Active Recombinant Human FCGR1A, His-tagged HEK293 His
Human FCGR1A-180H Active Recombinant Human FCGR1A, His-tagged, Biotinylated HEK293 His
Human FCGR1A-27573TH Recombinant Human FCGR1A, Fc-tagged Wheat Germ Fc 100 amino acids
Human FCGR1A-3987H Recombinant Human FCGR1A Protein Wheat Germ N/A
Human FCGR1A-2224H Recombinant Human FCGR1A, His tagged Human Cell His
Human FCGR1A-3818H Recombinant Human Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64), AVI-tagged Human His
Human FCGR1A-12818H Recombinant Human FCGR1A, His-tagged E.coli His 21-290a.a.
Human FCGR1A-7166H Recombinant Human Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64), His-tagged E.coli His 16-292aa
Human FCGR1A-3988H Recombinant Human FCGR1A Protein, GST-tagged Wheat Germ GST
Human FCGR1A-6279HCL Recombinant Human FCGR1A 293 Cell Lysate HEK293 N/A
Human FCGR1-2562HCL Recombinant Human FCGR1 cell lysate Human Cell N/A
Human FCGR1A-4736HF Recombinant Full Length Human FCGR1A Protein In Vitro Cell Free System 840 amino acids
Human FCGR1A-540H Recombinant Human FCGR1A Protein HEK293 374
Human FCGR1A-151H Recombinant Human FCGR1A Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human FCGR1A-27573H Recombinant Human FCGR1A Protein, GST-tagged Wheat Germ GST
Human FCGR1A-4737HF Recombinant Full Length Human FCGR1A Protein, GST-tagged In Vitro Cell Free System GST 374 amino acids
Human FCGR1A-301311H Recombinant Human FCGR1A protein, GST-tagged E.coli GST Val311-Thr374
Human FCGR1A-1038H Recombinant Human FCGR1A Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 16-374aa
Human FCGR1A-381H Recombinant Human FCGR1A protein, His-Avi-tagged HEK293 His-Avi It contains Gln 16 - Pro 288.
Human FCGR1A-584H Active Recombinant Human FCGR1A Protein, His-tagged HEK293 His Gln16-Leu281
Human FCGR1A-1210H Recombinant Human FCGR1A Protein (Gln35-Thr235), N-His tagged E.coli N-His Gln35-Thr235
Human FCGR1A-4107H Recombinant Human FCGR1A Protein (Met1-Pro288), C-His tagged Mammalian cells C-His Met1-Pro288
Human FCGR1A-2454H Recombinant Human FCGR1A Protein (Gln16-Pro288), C-His tagged Mammalian cells C-His Gln16-Pro288
Human FCGR1A-373H Active Recombinant Human FCGR1A Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Gln 16 - Pro 288
Rat Fcgr1a-4081R Active Recombinant Rat Fcgr1a protein, His-tagged HEK293 His Met1-Pro285
Rat FCGR1-1972RCL Recombinant Rat FCGR1 cell lysate Human Cell N/A
Rat CAB11539MR Mouse Anti-Rat CD64 Monoclonal Antibody Mouse N/A
Rhesus monkey FCGR1A-1799R Recombinant Rhesus Monkey FCGR1A Protein, mIgG1-tagged HEK293 mIgG1
Rhesus monkey FCGR1A-1798R Recombinant Rhesus Monkey FCGR1A Protein HEK293 N/A
Rhesus monkey FCGR1A-1800R Recombinant Rhesus Monkey FCGR1A Protein, mIgG2a-tagged HEK293 mIgG2a
Rabbit FCGR1A-904R Recombinant Rabbit FCGR1A Protein (Met1-Phe291), His-tagged HEK293 His Met1-Phe291
Cynomolgus FCGR1A-3818C Active Recombinant Cynomolgus FCGR1A protein, His-Avi-tagged, Biotinylated HEK293 His/Avi Val11-Pro288
Cynomolgus Monkey FCGR1A-01C Active Recombinant Cynomolgus Monkey FCGR1A Protein, His-tagged HEK293 His 11-288
Homo sapiens (Human) RFL2641HF Recombinant Full Length Human High Affinity Immunoglobulin Gamma Fc Receptor I(Fcgr1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (16-374aa)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FCGR1A involved in several pathways and played different roles in them. We selected most pathways FCGR1A participated on our site, such as Phagosome, Osteoclast differentiation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeATP6V0B;STX7;SEC61AL2;MHC1UXA2;MRC2;FCGR1;ATP6V0A4;ATP6V1C2;ATP6V0A2
Osteoclast differentiationSOCS1;FOS;RELA;SPI1;LILRA4;PIK3R1;LILRA5;TGFB2;CALCR
Hematopoietic cell lineageCD3G;CD1D2;CD59;ITGA2B;CD2;FLT3;CD1B;ANPEP;CD3E
Fc gamma R-mediated phagocytosisNCF1;PIK3R5;PLD1;PRKCG;SCIN;MAPK1;BIN1;WASF1;MYO10
LeishmaniasisNFKBIA;HLA-DPB1;IL1B;NCF1;IFNGR2;FCGR2C;FCGR3B;FOS;NCF4
Staphylococcus aureus infectionFCGR3;CFB;HLA-DPA1;C1QA;FCGR4;MASP1;FCGR2B;C3;SELP
TuberculosisMRC2;IFNA1;MRC1;MAPK11;FCGR4;AKT2;CALML3;RAB5C;Itgam&Itgb2
Transcriptional misregulation in cancerPPARG;TLX1;HIST2H3C1;CD14;FOXO1;ETV4;FEV;SFPI1;HIST2H3A
Systemic lupus erythematosusACTN4;TROVE2;H2AFB1;HIST1H2BC;TNF;HLA-DMA;H3F3C;HIST1H4B;GRIN2B

FCGR1A has several biochemical functions, for example, IgG binding, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR1A itself. We selected most functions FCGR1A had, and list some proteins which have the same functions with FCGR1A. You can find most of the proteins on our site.

Function Related Protein
IgG bindingFCGR2B;FCER1G;FCGR2C;UMOD;FCGR3B;FCGR2A;FCGR1;cgr2b;FCGRT
protein bindingTRIM35;PCGF3;SLC22A7;TRIM54;GNG5;SDCCAG3;NUDT21;CHCHD1;EFNA4
receptor signaling protein activityDOK5;KLK1B3;BAG4;KLK1B4;RAF1A;TYROBP;IL1RL1;NCR1;ADCYAP1

FCGR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR1A.

FCGR3A; SYK; hldE; CBL; SHC1; LCP2

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