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G6PC

Official Full Name

glucose-6-phosphatase, catalytic subunit
Overview

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.
Synonyms

G6PC; glucose-6-phosphatase, catalytic subunit; G6PT, glucose 6 phosphatase, catalytic (glycogen storage disease type I, von Gierke disease); glucose-6-phosphatase; glycogen storage disease type I; von Gierke disease; GSD1a; GSD1; AW107337; G-6-Pase; G6Pase; G6Pase-alpha; G6PC_HUMAN; G6PT; Glucose-6-phosphatase alpha; MGC163350; MGC93613; RP23-281C18.19; G6PC1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Haplochromis xenognathus (Lake Victoria cichlid) (Ptyochromis xenognathus)
Human
Mouse
Rat

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	G6PC-27523TH	Recombinant Human G6PC	Wheat Germ	N/A	357 amino acids	Inquiry
Human	G6PC-6082HCL	Recombinant Human G6PC 293 Cell Lysate	HEK293	N/A		Inquiry
Human	G6PC-4613H	Recombinant Human G6PC Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	G6PC174HF	Recombinant Full Length Human G6PC Protein	In Vitro Cell Free System		357 amino acids	Inquiry
Human	G6PC-1542H	Recombinant Human G6PC Protein, His-tagged	E.coli	N-His	Val57-Ala204	Inquiry
Human	G6PC-1543H	Recombinant Human G6PC protein, His-tagged	E.coli	His	Asn276~Leu357	Inquiry
Human	G6PC-5122HF	Recombinant Full Length Human G6PC Protein, GST-tagged	In Vitro Cell Free System	GST	357 amino acids	Inquiry
Mouse	G6PC-6129M	Recombinant Mouse G6PC Protein	Mammalian Cell	His		Inquiry
Mouse	G6pc-944M	Recombinant Mouse G6pc Protein, His-tagged	Insect Cell	N-His	Met1-Leu357	Inquiry
Mouse	G6PC-3416M	Recombinant Mouse G6PC Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	G6PC-3416M-B	Recombinant Mouse G6PC Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	G6PC-2435R	Recombinant Rat G6PC Protein	Mammalian Cell	His		Inquiry
Rat	G6PC-2091R	Recombinant Rat G6PC Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	G6PC-2091R-B	Recombinant Rat G6PC Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Haplochromis xenognathus (Lake Victoria cichlid) (Ptyochromis xenognathus)	RFL23531HF	Recombinant Full Length Haplochromis Xenognathus Glucose-6-Phosphatase(G6Pc) Protein, His-Tagged	E.coli expression system	His	Full Length (1-277)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
G6PC Related Articles

G6PC involved in several pathways and played different roles in them. We selected most pathways G6PC participated on our site, such as Glycolysis / Gluconeogenesis, Galactose metabolism, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with G6PC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycolysis / Gluconeogenesis	ALDH9A1B;ENO1B;PFKM;GM5506;TPI1;MINPP1A;PCK2;AKR1A1;PGAM2
Galactose metabolism	AKR1B1;AKR1B7;UGP2B;HKDC1;B4GALT2;PGM1;GALT;G6PCA.1;Akr1b3
Starch and sucrose metabolism	ENPP1;PYGM;PGM2;ENPP3;GPI1;UGP2;KL;AMY2A3;GANC
Metabolic pathways	NDUFB5;HGSNAT;mt-Atp8;EXT1;AGPAT9;PIGX;NDUFA1;COQ6;SORD
FoxO signaling pathway	FOXO1A;PCK2;AKT1;MAPK10;MAPK3;PRKAA1;AGAP2;RAF1A;NLK2
PIK-Akt signaling pathway	HRAS;IFNA21;IL3RA;LPAR5;CCNE1;THBS1;IL2RG;ITGA6;CCND2
AMPK signaling pathway	CREB3L2;CCNA2;PIK3CD;Scd2;CPT1A;ADIPOR1;PCK2;RAB10;PCK1
Insulin signaling pathway	PRKAR2A;EIF4E1B;PRKAR1AB;PIK3R3A;PTPN1;PPP1R3CA;GRB2A;GSK3B;SOCS2
Adipocytokine signaling pathway	ADIPOQ;LEPR;NPY;CHUK;ACSL1;AKT2;PRKAB1;STAT3;ACSL4
Insulin resistance	PRKAA2;PPP1R3CA;PPP1CAA;SLC2A1A;PPARAB;G6PC2;PDPK1B;RPS6KB1B;CREB1A
Carbohydrate digestion and absorption	ATP1A1;ATP1B2;ATP1B1;FXYD2;AMY1A;HK1;PIK3R5;HKDC1;PIK3CA

G6PC has several biochemical functions, for example, glucose-6-phosphatase activity, phosphate ion binding, phosphotransferase activity, alcohol group as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by G6PC itself. We selected most functions G6PC had, and list some proteins which have the same functions with G6PC. You can find most of the proteins on our site.

Function	Related Protein
glucose-6-phosphatase activity	G6PC;G6PC3;G6PCA.2;G6PC2;G6PCA.1
phosphate ion binding	SH2B3;ADSS;MTHFD2;RELA;SLC34A2;ADSSL1;RPH3A;G6PC;CHST14
phosphotransferase activity, alcohol group as acceptor	ADKA;POMK;PI4KAB;SGK196;PI4KAP2;G6PC;GKUP;FAM20B;ADKB

G6PC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with G6PC here. Most of them are supplied by our site. Hope this information will be useful for your research of G6PC.

CDH16; NSL1; SNX13

Zhou, YL; Wei, XH; et al. Potassium diformate influences gene expression of GH/IGF-I axis and glucose homeostasis in weaning piglets. LIVESTOCK SCIENCE 172:85-90(2015).

Zheng, BX; Lin, Q; et al. Three novel mutations of the G6PC gene identified in Chinese patients with glycogen storage disease type Ia. EUROPEAN JOURNAL OF PEDIATRICS 174:59-63(2015).