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GABBR2

Official Full Name

gamma-aminobutyric acid (GABA) B receptor, 2
Overview

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
Synonyms

GABBR2; gamma-aminobutyric acid (GABA) B receptor, 2; G protein coupled receptor 51 , GPR51; gamma-aminobutyric acid type B receptor subunit 2; GABABR2; GPRC3B; HG20; gb2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; GABA-B receptor, R2 subunit; G protein-coup;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Flag
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GABBR2-13088H	Recombinant Human GABBR2, GST-tagged	E.coli	GST	59-386a.a.	$319 / 25ug
Human	GABBR2-6072HCL	Recombinant Human GABBR2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GABBR2-4629H	Recombinant Human GABBR2 Protein	Wheat Germ	N/A		Inquiry
Human	GABBR2-1117HFL	Recombinant Human GABBR2 protein, His&Flag-tagged	HEK293	His&Flag	1-941 aa	Inquiry
Human	GABBR2-5178HF	Recombinant Full Length Human GABBR2 Protein, GST-tagged	In Vitro Cell Free System	GST	883 amino acids	Inquiry
Human	GABBR2-4630H	Recombinant Human GABBR2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GABBR2-5163HF	Recombinant Full Length Human GABBR2 Protein	In Vitro Cell Free System		292 amino acids	Inquiry
Mouse	GABBR2-6142M	Recombinant Mouse GABBR2 Protein	Mammalian Cell	His		Inquiry
Mouse	GABBR2-3425M-B	Recombinant Mouse GABBR2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GABBR2-3425M	Recombinant Mouse GABBR2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GABBR2-2443R	Recombinant Rat GABBR2 Protein	Mammalian Cell	His		Inquiry
Rat	GABBR2-2099R-B	Recombinant Rat GABBR2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	GABBR2-2099R	Recombinant Rat GABBR2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	GABBR2-7268Z	Recombinant Zebrafish GABBR2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GABBR2 Related Articles

GABBR2 involved in several pathways and played different roles in them. We selected most pathways GABBR2 participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cAMP signaling pathway	GPR81;MAPK1;CALML3;F2R;ATP1B1;GHRL;EP300;PLCE1;CNGA1
Neuroactive ligand-receptor interaction	Chrng;LHB;PTGER4C;HTR1B;LPAR6A;CHRNA6;GLRA3;GABRA3;CHRNE
GABAergic synapse	GNGT2;GABRD;GNAI3;GABRA5;GNG3;GNG11;GABRA6;GNAI2;GNG10
Estrogen signaling pathway	HRAS;CALM2;ESR1;ATF4;PRKACG;SHC2;PIK3CA;GNAI1;CREB5

GABBR2 has several biochemical functions, for example, contributes_to G-protein coupled GABA receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABBR2 itself. We selected most functions GABBR2 had, and list some proteins which have the same functions with GABBR2. You can find most of the proteins on our site.

Function	Related Protein
contributes_to G-protein coupled GABA receptor activity	GABBR2;GABBR1
protein binding	HAGH;SRI;SENP1;POLD3;STAT6;NAV1;ERCC3;TNNI1;CAPN2

GABBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABBR2.

NSF; GABBR1; Dlg4; CERS2; SH3GL3; Cacna1d

Appenzeller, S; Balling, R; et al. De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies. AMERICAN JOURNAL OF HUMAN GENETICS 95:360-370(2014).

Terranova, C; Tucci, M; et al. GABA Receptors Genes Polymorphisms and Alcohol Dependence: No Evidence of an Association in an Italian Male Population. CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE 12:142-148(2014).