Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Gad2

  • Official Full Name

    glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

  • Overview

    Adults express two forms of glutamate decarboxylase (GAD), GAD65 and GAD67, which are encoded by different independently regulated genes. Both are expressed in most GABA containing neurons. GAD65 appears to be targeted to the membrane and nerve endings; while GAD67 is more widely distributed throughout the cell. GAD65 preferentially synthesizes GABA for vesicular release and GAD67 preferentially synthesizes cytoplasmic GABA. GAD65 is predominantly expressed in pancreatic beta cells and autoantibodies to GAD65 are strongly associated with Insulin-dependent diabetes mellitus (IMDM).
  • Synonyms

    GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2; GAD65; GAD-65; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 65 kDa isoform; MGC161605; MGC161607;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GAD2-26072TH Recombinant Human GAD2 Wheat Germ N/A 585 amino acids
Human GAD2-9250H Recombinant Human GAD2 protein, GST tagged Insect Cell GST Met1-Leu585
Human GAD2-13107H Recombinant Human GAD2, GST-tagged E.coli GST 1-180a.a.
Human GAD2-9169H Recombinant Human GAD2 Protein, His-tagged E.coli His
Human GAD2-23H Recombinant Human GAD2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GAD2-6734H Recombinant Human GAD2 protein, His & GST-tagged E.coli His/GST Arg65~Arg105
Human GAD2-22H Recombinant Human GAD2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GAD2-1556H Recombinant Human GAD2 Protein, His-tagged E.coli N-His Met188-Ser374
Human GAD2-4655H Recombinant Human GAD2 Protein, GST-tagged Wheat Germ GST
Human GAD2-5828H Recombinant Human GAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GAD2-4173H Recombinant Human GAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GAD2-1557H Recombinant Human GAD2 Protein, His-tagged E.coli N-His Met188-Ser374
Human GAD2-3178H Recombinant Human GAD2 protein, His-tagged E.coli His 200-550 aa
Human GAD2-185HF Recombinant Full Length Human GAD2 Protein In Vitro Cell Free System 585 amino acids
Human GAD2-956H Recombinant Human GAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GAD2-5205HF Recombinant Full Length Human GAD2 Protein, GST-tagged In Vitro Cell Free System GST 585 amino acids
Human GAD2-2538H Recombinant Human GAD2 Protein (Gln152-Asp496), N-His tagged E.coli N-His Gln152-Asp496
Human GAD2-517HFL Recombinant Full Length Human GAD2 Protein, C-Flag-tagged Mammalian cells Flag
Human GAD2-9170H Recombinant Human GAD2 Protein, N-His tagged E.coli N-His
Human GAD2-956H-B Recombinant Human GAD2 Protein Pre-coupled Magnetic Beads HEK293
Mouse GAD2-437M Recombinant Mouse Gad2, Gly & Pro tagged Insect Cell His
Mouse Gad2-860M Recombinant Mouse Gad2, His & GST tagged Insect Cell His/GST
Mouse GAD2-001MCL Recombinant Mouse GAD2 cell lysate Insect Cell N/A
Mouse GAD2-512M Recombinant Mouse GAD2 Protein (1-585 aa), His-tagged E.coli His 1-585 aa
Mouse GAD2-1303M Recombinant Mouse GAD2 protein(Met1-Leu585) Insect Cells N/A Met1-Leu585
Mouse GAD2-28M Recombinant Mouse GAD2 Protein, His-tagged E.coli His
Mouse Gad2-3129M Recombinant Mouse Gad2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Gad2-6736R Recombinant Rat Gad2 protein, His-tagged E.coli His Met188~Ser374 (Accession # Q05683)
Rat Gad2-6735R Recombinant Rat Gad2 protein, His & S-tagged E.coli His/S Met1~Ala150 (Accession # Q05683)
Rat GAD2-2458R Recombinant Rat GAD2 Protein Mammalian Cell His
Rat GAD2-2114R Recombinant Rat GAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GAD2-2114R-B Recombinant Rat GAD2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GAD2-1797R Recombinant Rhesus monkey GAD2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GAD2-1618R-B Recombinant Rhesus Macaque GAD2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GAD2-1618R Recombinant Rhesus Macaque GAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GAD2-2466Z Recombinant Zebrafish GAD2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Gad2 Related Articles
  • Gad2 Related Research Area

Gad2 involved in several pathways and played different roles in them. We selected most pathways Gad2 participated on our site, such as Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gad2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alanine, aspartate and glutamate metabolismGPT2;ADSS;GLS;GLS2;ybaS;ASNS;CPS1;CAD;AGXT2
beta-Alanine metabolismALDH2;ALDH3B2;ALDH1B1;CNDP1;HADHAA;AOC3;ALDH9A1B;MLYCD;SRM
Taurine and hypotaurine metabolismCDO1;GGT7;CSAD;GAD1;ADOB;GGT5;GAD2;GGT1;GGT1A
Butanoate metabolismACADS;ACSM3;ACSM1;OXCT1A;HMGCS1;ALDH5A1;ECHS1;EHHADH;ACSM2B
Metabolic pathwaysAHCYL2;CYP2A4;PTGS2B;LALBA;PCCB;PIGU;ALDH9A1A.1;CHSY3;TKTB
GABAergic synapseSLC38A2;PRKCA;GABRA3;GNB2;GABRR1;PLCL1;SLC12A5;GNG12;GABRA2
Type I diabetes mellitusTNF;HLA-DMB;HLA-DRA;HLA-DRB1;HSPD1;HLA-B;FAS;INS;HLA-DRB5

Gad2 has several biochemical functions, for example, glutamate binding, glutamate decarboxylase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gad2 itself. We selected most functions Gad2 had, and list some proteins which have the same functions with Gad2. You can find most of the proteins on our site.

Function Related Protein
glutamate bindingSLC1A1;GCLC;GRIN1;GLUL;GRIK1;GRM7;GRIN2A;CPS1;GAD2
glutamate decarboxylase activityGAD2;GAD1B;GLUL;GAD1
protein bindingIL1RL1;SGOL1;UBE2D2A;PSG1;RNF41;POLD4;VAMP1;DYNAP;CECR2
protein heterodimerization activitySCUBE1;H2-AA;Pdgfa&Pdgfb;ATF2;MPP7;BCL2;DMRT3A;RXRA;GCLM
pyridoxal phosphate bindingMOCOS;GCAT;TAT;SDSL;PYGM;PYGB;CCBL1;SGPL1;SPTLC3

Gad2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gad2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gad2.

ARL6IP1; AGTRAP; MAL2; TMEM159; CMTM5

Werner, C; Haselmann, H; et al. Stiff person-syndrome IgG affects presynaptic GABAergic release mechanisms. JOURNAL OF NEURAL TRANSMISSION 122:357-362(2015).
Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is there a genetic component related to GAD2 protein and neurological disorders? 07/17/2022

Yes, genetic variations in the GAD2 gene have been associated with an increased risk of developing certain neurological disorders, indicating a genetic component in their etiology.

Can GAD2 protein levels be manipulated pharmacologically? 10/08/2020

Pharmacological agents targeting GAD2 activity are being explored to modulate GABAergic neurotransmission, potentially offering novel treatments for neurological disorders.

Can GAD2 protein be used as a diagnostic marker for neurological disorders? 12/16/2019

Yes, elevated or reduced levels of GAD2 protein can serve as a diagnostic marker for certain neurological disorders, aiding in their identification and management.

How is GAD2 protein linked to neurological disorders? 06/19/2019

GAD2 protein is linked to neurological disorders like epilepsy, Parkinson's disease, and various psychiatric conditions due to its role in regulating GABA levels, which are crucial for proper neuronal function.

Are there any therapeutic interventions targeting GAD2 protein? 04/24/2019

Research is ongoing to develop therapeutic interventions that modulate GAD2 activity, aiming to restore GABAergic balance in the brain and potentially treat related neurological disorders.

Customer Reviews (3)

Write a review
Reviews
04/14/2023

    The GAD2 protein exhibits remarkable performance in Western blotting (WB) experiments.

    12/13/2022

      The versatility and efficacy of GAD2 in these applications make it an invaluable tool for researchers.

      11/11/2019

        Researchers can rely on GAD2 to deliver reliable and accurate results in ELISA experiments, ensuring precise measurement and quantification of target proteins.

        Ask a Question for All Gad2 Products

        Required fields are marked with *

        My Review for All Gad2 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends