GALNS
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Official Full Name
galactosamine (N-acetyl)-6-sulfate sulfatase
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Overview
This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. -
Synonyms
GALNS; galactosamine (N-acetyl)-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfatase; GALNAC6S; GAS; Morquio syndrome; mucopolysaccharidosis type IVA; Chondroitinase; Chondroitinsulfatase; FLJ00319; FLJ17434; FLJ42844; FLJ98217; Galactosamine (N acetyl) 6 sulfate sulfatase; Galactose 6 sulfate sulfatase; GalNAc6S sulfatase; mFLJ00319; MPS4A; N acetylgalactosamine 6 sulfatase; N acetylgalactosamine 6 sulfate sulfatase; galactose-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfate sulfatase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Sf21 Insect Cell
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- GALNS Related Articles
GALNS involved in several pathways and played different roles in them. We selected most pathways GALNS participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan degradation | GUSB;ARSB;GLB1;IDUA;HYAL4;HEXA;HYAL1;HYAL3;HPSE |
| Metabolic pathways | ACOX3;POLR1C;GUK1B;HSD3B1;COX5A;MINPP1A;DAK;DGUOK;PSPH |
| Lysosome | DNASE2A;NAPSA;TPP1;GUSB;IGF2R;MCOLN1;ATP6V0B;GBA;ATP6AP1B |
GALNS has several biochemical functions, for example, N-acetylgalactosamine-4-sulfatase activity, N-acetylgalactosamine-6-sulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNS itself. We selected most functions GALNS had, and list some proteins which have the same functions with GALNS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetylgalactosamine-4-sulfatase activity | ARSB;GALNS |
| N-acetylgalactosamine-6-sulfatase activity | |
| metal ion binding | RAB11FIP4A;TRP53;LHX6;NEK11;MGRN1B;PNKD;NRXN3A;CASZ1;CADPS |
| sulfuric ester hydrolase activity | GNSB;SULF2B;SULF2A;STS;ARSA;GNSA;SGSH;GALNS;GNS |
GALNS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNS here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNS.
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