GALNT4
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Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
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Overview
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5 exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist. -
Synonyms
GALNT4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4); polypeptide N-acetylgalactosaminyltransferase 4; GalNAc T4; EC 2.4.1.41; GalNAc transferase 4; GalNAc-T4; GalNAcT4; GALT4_HUMAN; N-acetylgalactosaminyltransferase 4 (GalNAc-T4); Polypeptide GalNAc transferase 4; pp GaNTase 4; pp-GaNTase 4; Protein UDP acetylgalactosaminyltransferase 4; Protein-UDP acetylgalactosaminyltransferase 4; UDP GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- Rhesus Macaque
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GALNT4 Related Articles
GALNT4 involved in several pathways and played different roles in them. We selected most pathways GALNT4 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mucin type O-Glycan biosynthesis | GALNT2;GCNT4A;B4GALT5;POC1BL;B3GNT6;GALNT18;GCNT4;GALNT4;GALNT12 |
| Metabolic pathways | ADI1;ALG5;GBE1;GRHPRA;POLR2J2;ACSBG2;ADH6;NME4;IMPA2 |
GALNT4 has several biochemical functions, for example, carbohydrate binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT4 itself. We selected most functions GALNT4 had, and list some proteins which have the same functions with GALNT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | ZG16B;KLRC4-KLRK1;FCNA;ACAN;CLEC7A;LAYN;KLRD1;CHI3L2;Siglec1 |
| metal ion binding | CYP2C38;NPTX2;MAP3K3;PRDM14;HIVEP2A;ITGAX;ZBTB43;CPPED1;RNASEH2A |
| polypeptide N-acetylgalactosaminyltransferase activity | GALNTL6;GALNT1;GALNT4;GALNT5;C1GALT1C1;GALNTL2;GALNT14;GALNT12;WBSCR17 |
GALNT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT4.
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