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GALNT6

Official Full Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
Overview

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.
Synonyms

GALNT6; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6); polypeptide N-acetylgalactosaminyltransferase 6; GALNAC T6; GalNAc transferase 6; GalNAcT6; GALNT 6; Polypeptide GalNAc transferase 6; Polypeptide N acetylgalactosaminyltransferase 6; pp GaNTase 6; Protein UDP acetylgalactosaminyltransferase 6; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 6; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 6 (GalNAc T6); UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 6; pp-GaNTase 6; protein-UDP acetylgalactosaminyltransferase 6; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6; UDP-N-acetyl-alpha-D-galactosamine:; GALNAC-T6;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GALNT6-22H	Recombinant Human GALNT6 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	GALNT6-6035HCL	Recombinant Human GALNT6 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GALNT6-6318H	Recombinant Human GALNT6 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	GALNT6-5268HF	Recombinant Full Length Human GALNT6 Protein, GST-tagged	In Vitro Cell Free System	GST	622 amino acids	Inquiry
Human	GALNT6-4704H	Recombinant Human GALNT6 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	GALNT6-6189M	Recombinant Mouse GALNT6 Protein	Mammalian Cell	His		Inquiry
Mouse	GALNT6-3453M-B	Recombinant Mouse GALNT6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GALNT6-3453M	Recombinant Mouse GALNT6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Galnt6-3144M	Recombinant Mouse Galnt6 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	GALNT6-12406Z	Recombinant Zebrafish GALNT6	Mammalian Cell	His		Inquiry
Chicken	GALNT6-3219C	Recombinant Chicken GALNT6	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

GALNT6 involved in several pathways and played different roles in them. We selected most pathways GALNT6 participated on our site, such as Metabolic pathways, Metabolism of proteins, Mucin type O-Glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolic pathways	GLS2;GUK1A;GALCA;COQ7;UGDH;CKMT1;NT5C;CBR1L;MIBP
Metabolism of proteins	SERP1;B3GNT6;RHBDL1;DMBT1;TIMM44;CTSG;CST3;PAPPA2;ADAMTS5
Mucin type O-Glycan biosynthesis	C1GALT1B;GALNTL6;GALNT4;B3GNT6;GALNT18A;GALNT10;C1GALT1;GALNTL1;WBSCR17
O-linked glycosylation	B3GNT8;ADAMTSL4;GCNT3;GALNTL5;THSD7A;SPON1A;B3GALTL;MUC12;GALNTL2
O-linked glycosylation of mucins	MUC12;MUC1;MUCL1;B3GNT8;B3GNT6;A4GNT;B3GNT2A;MUC21;GCNT3
Post-translational protein modification	GALNTL5;EID3;ADAMTS1;TRAPPC9;GCNT3;KCNA6;UBA2;NAPAB;DPH5
mucin core 1 and core 2 O-glycosylation	GALNT6;GALNT13;GALNT5;GALNTL2;GCNT3

GALNT6 has several biochemical functions, for example, carbohydrate binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT6 itself. We selected most functions GALNT6 had, and list some proteins which have the same functions with GALNT6. You can find most of the proteins on our site.

Function	Related Protein
carbohydrate binding	NOMO2;LGALS8;ACAN;CALR;VCAN;SBP;CLEC4A2;AIM1;SIGLEC12
metal ion binding	ZDHHC15A;ZNF485;ROCK2A;ITGAE;SMYD1B;ZNF521;ATF7B;ZRANB1B;ZDHHC1
polypeptide N-acetylgalactosaminyltransferase activity	GALNT2;GALNT12;GALNT6;GALNT9;GALNT11;GALNT1;GALNT10;GALNT5;GALNT13

GALNT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT6.

ALDOA; TMEM9; SLC5A6; AK6