GALT
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Official Full Name
galactose-1-phosphate uridylyltransferase
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Overview
Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. -
Synonyms
GALT; galactose-1-phosphate uridylyltransferase; gal-1-P uridylyltransferase; galactose-1-phosphate uridyl transferase; UDP-glucose--hexose-1-phosphate uridylyltransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bacillus subtilis
- Human
- Mouse
- Rat
- Yeast
- Zebrafish
- E. coli or Yeast
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|T7
- SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GALT Related Articles
GALT involved in several pathways and played different roles in them. We selected most pathways GALT participated on our site, such as Galactose metabolism, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Galactose metabolism | G6PC;PFKL;AKR1B8;SI;GANC;AKR1B1L;LCT;G6PCA.1;HK1 |
Amino sugar and nucleotide sugar metabolism | GNPDA1;CYB5R4;CYB5RL;HK3;TSTA3;GNPNAT1;FUK;GALT;GNE |
Metabolic pathways | DGAT1A;MTR;B3GNT5;NT5C;GFPT2;HSD3B4;CBR1;POLR3B;CHPT1 |
Prolactin signaling pathway | MAPK9;INS1;ESR1;SOCS7;NFKB1;PIK3R2;SHC4;STAT3;SOCS6 |
GALT has several biochemical functions, for example, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GALT itself. We selected most functions GALT had, and list some proteins which have the same functions with GALT. You can find most of the proteins on our site.
Function | Related Protein |
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UDP-glucose:hexose-1-phosphate uridylyltransferase activity | |
protein binding | SKIV2L2;H2-KE2;ASAP1;ASAP3;PLOD3;C1QB;NHLH2;CTSH;EIF4EBP1 |
zinc ion binding | NR4A2A;LMO2;RNF43;TRIM30A;PHF15;ATXN7L3;SORD;RARGB;ADAMTS16 |
GALT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALT here. Most of them are supplied by our site. Hope this information will be useful for your research of GALT.
TNK2; TRIP13
- Q&As
- Reviews
Q&As (5)
Ask a questionTreatment for GALT deficiency involves a strict lactose-free diet, which means avoiding milk, dairy products, and other foods containing galactose.
Individuals with GALT deficiency are recommended to avoid galactose-containing foods, and dietary supplementation with essential nutrients may be necessary.
Yes, if left untreated, GALT deficiency can lead to long-term complications such as liver damage, cognitive impairment, and reproductive issues.
Yes, GALT enzyme activity levels can be measured in the blood to diagnose GALT deficiency.
Symptoms of galactosemia include jaundice, poor feeding, vomiting, liver enlargement, and failure to thrive in infants. In older children and adults, symptoms may include cognitive impairment, speech difficulties, and ovarian insufficiency in females.
Customer Reviews (3)
Write a reviewThe GALT Protein is an exceptional product that fully meets my experimental needs.
Its versatility and reliability make it a top choice for researchers in various fields.
The GALT Protein's adaptability has significantly expanded the scope of my investigations and broadened the possibilities for my research.
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